Aerius tablets from allergies, 10 pcs., Bayer

Description

Composition
Active substance:
1 tablet contains: 5 mg desloratadine.
Excipients:
Calcium hydrogen phosphate dihydrate 53 mg microcrystalline cellulose 28 mg Corn starch 11 mg talc 3 mg.
shell tablets: Opadry Blue (lactose monohydrate, hypromellose, titanium dioxide, macrogol, blue lacquer aluminum) 6 mg Opadry Clear (hypromellose, macrogol) 0.6 mg 0.005 mg Carnauba wax, beeswax white 0.005 mg.
Round biconvex blue. On one side of the tablet caused by embossing trade mark firm Schering – Plow a stylized letters SP.
Description:
Aerius – Tablets from allergies, the active substance desloratadine.
You are looking for a cure for allergies?
Aerius tablets – is the latest generation of the drug, c triple activity against allergy: anti-inflammatory, anti-histamine and anti-allergic (1).
Aerius 10 helps eliminate allergy symptoms:
– Itching, redness, and tearing eyes;
– congestion, sneezing, itching and runny nose;
– Itching of the sky;
– Itching of the skin, rash.
The drug is indicated:
– with seasonal and perennial allergic rhinitis;
– hives
Unlike some other antihistamines II generation (2) Erius does not interact with drugs and alcohol (3) does not cause drowsiness (possible frequency of less than 1 in 10 000 patients).
1, the drug is taken once a day, capable to act for 30 minutes after administration and have an effect within 24 hours. Adults and adolescents from 12 years: 1 tablet (5 mg), 1 per sutki.Teper in new packaging!
(1). . Canonica GW, Blaiss M. Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence. World Allergy Organ J. 2011 Feb; 4 (2): 47-53.
(2). For example, when used in conjunction with erythromycin fexofenadine or fexofenadine concentration of ketoconazole in the plasma increases, aluminum or magnesium containing antacids reduce the bioavailability of fexofenadine (Allegra instructions for use of the drug); simultaneous application of cetirizine with alcohol or drugs, CNS depressants, can further reduce the concentration and speed of reactions (Zirtek instructions for use of the drug).
(3). With alcohol should be used with caution ”
Product form:
10 coated tablets.
Contraindications
Hypersensitivity to any – any of the substances included in the preparation,
Pregnancy and lactation,
Age up to 12 years.
With OSTOROZHNOSTYU- severe renal insufficiency.
Dosage
5 mg
Indications
Allergic rhinitis (elimination or alleviation of sneezing, nasal congestion, nasal mucus, itching nose, palate pruritus, itching and redness of the eyes, tearing);
Urticaria (reduction or elimination of itching, rashes).
Interaction with other drugs
The interaction with other drugs is not revealed. Eating does not affect the efficacy of the drug. Erius® does not increase the alcohol effects on the central nervous system.
Overdose
Symptoms. Receiving dose exceeding the recommended 5 times did not lead to the appearance of any symptoms. In clinical trials, daily use in adults and adolescents desloratadine at a dose of 20 mg for 14 days is not associated with a statistically or clinically significant changes of the cardio – vascular system. In clinical – pharmacological study of the use of desloratadine in a dose of 45 mg per day (at 9 times the recommended) for 10 days did not cause QT interval elongation and the appearance was not accompanied by serious side effects.
Treatment. In case of accidental ingestion of large amounts of the drug should contact a doctor immediately. Recommended gastric lavage, administration of activated charcoal; if necessary – symptomatic therapy. Desloratadine does not appear in hemodialysis, peritoneal dialysis efficacy has not been established.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H 1 – histamine receptor blocker.
Pharmacodynamics:
Long-acting antihistamine. It is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammation, including – the release of pro-inflammatory cytokines including the interleukins IL -4, IL -6, IL -8, IL -13, release of proinflammatory chemokines (RANTES), superoxide anion production by activated polymorphonuclear neutrophils adhesion and chemotaxis eosinophils , selection of adhesion molecules such as P – selectin, IgE- mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the two allergic reactions, and possesses protivoekssudativnoe antipruritic effect, reduces capillary permeability, prevents the development of edema, smooth muscle spasm.
The drug has no effect on the central nervous system with practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions. It does not cause QT prolongation on the ECG.
Action Erius® medicinal preparation starts within 30 minutes after ingestion and continues for 24 hours.
Pharmacokinetics:
Desloratadine is well absorbed in the gastro – intestinal tract. Determined in blood plasma within 30 minutes after ingestion. The maximum concentration is achieved after an average of 3 hours after ingestion. It does not cross the blood-brain barrier. Communication plasma protein is 83-87%. In the application for adults and adolescents over 14 days in a dose of 5 mg to 20 mg 1 time per day clinically significant drug accumulation is not observed. Simultaneous food intake or grapefruit juice does not affect the distribution of desloratadine at an application rate of 7.5 mg 1 time per day. Desloratadine is not an inhibitor of CYP3A4 and CYP2D6, and is not a substrate or inhibitor of P- glycoprotein. It is extensively metabolized in the liver by hydroxylation to form 3-OH – desloratadine connected to glucuronide. Only a small part of an oral dose is excreted by the kidneys (
Pregnancy and breast-feeding
Use of the drug is contraindicated during pregnancy due to lack of clinical data on the safety of the drug during pregnancy Erius®.
Desloratadine, the active substance is excreted in breast milk, therefore the use of the drug Erius® during breastfeeding is contraindicated.
Conditions of supply of pharmacies
Without recipe.
side effects
Fatigue (1.2% of the cases), xerostomia (0.8%), headache (0.6%).
Very rarely observed following side effects: tachycardia, palpitations, elevated liver enzymes, increased bilirubin concentration, allergic reactions, including anaphylaxis and rash.
special instructions
Studies of drug efficacy in rhinitis Erius® infectious etiology is not performed.
Effects on ability to drive vehicles and management mechanisms
The recommended dose Erius® does not affect the ability to drive vehicles and management mechanisms.
Storage conditions
At a temperature of not higher than 30 ° C, the reach of children.
Dosing and Administration
For ingestion. Tablets should be swallowed whole without chewing, and drink water. The drug should preferably be taken regularly at the same time of day, regardless of meal times.
Adults and adolescents from 12 years of age – 1 tablet (5 mg), 1 per day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist