Suprastin injection 20mg / ml 1ml ampoules 5 pcs

$3.47

Suprastin injection 20mg / ml 1ml ampoules 5 pcs

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SKU: 01794201942 Categories: , Tags: ,

Description

Composition
Active substance:
levocetirizine dihydrochloride 0.1 g (1 ml contains 5 mg of levocetirizine dihydrochloride);
Excipients:
glycerol (85%) of 5 g propylene glycol 7 g sodium saccharinate 0.2 g Sodium acetate trihydrate 0.12 g, 0.027 g of methyl parahydroxybenzoate, propyl parahydroxybenzoate 0.003 g, glacial acetic acid 0.010 g Purified water to 20 mL.
Description:
antiallergic agent H1-histamine receptor blocker
Product form:
Drops for oral administration of 5 mg / ml: 20 ml brown glass vial with a polyethylene dropper and a PP lid with an inner PE layer, provided with special protection against child resistant and tamper-evident. 1 vial is placed in a cardboard box, together with instructions for use.
Contraindications
– increased sensitivity to active (including piperazine derivatives) or any subsidiary component of the drug – severe renal impairment (creatinine clearance less than 10 mL / min)
– Children under 2 years (due to lack of clinical data)
– pregnancy and lactation
CAREFULLY
Chronic renal failure, advanced age (possibly reduction in glomerular filtration)
Dosage
20 mg / ml
Indications
Symptomatic treatment year (persistent) and seasonal allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, redness, conjunctival); hay fever (pollinosis); urticaria, including chronic idiopathic urticaria; angioedema; allergic dermatoses, accompanied by itching and rashes.
Interaction with other drugs
Studies of interactions of levocetirizine showed no clinically relevant interactions with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide and diazepam. The combined use of macrolides or ketoconazole did not cause significant changes in the ECG.
Theophylline (400 mg / day) reduced total clearance levocetirizine by 16%, while the kinetics of theophylline is not changed.
In sensitive patients the simultaneous reception of levocetirizine with alcohol or other CNS depressants may have effects on the central nervous system.
Overdose
Symptoms: drowsiness in children – anxiety, irritability.
Treatment: gastric lavage, activated charcoal, symptomatic therapy. No specific antidote. Hemodialysis is not effective.
pharmachologic effect
Pharmacodynamics:
Antiallergic agent. Enantiomer of cetirizine; competitive antagonist of histamine; blocking the H1-histamine receptors, the affinity of which is 2 times higher than that of the cetirizine. It affects gistaminozavisimuyu step allergic reactions; decreases eosinophil migration, reduces vascular permeability limits the release of inflammatory mediators. It prevents the development and facilitates the allergic reactions has antiexudative (decongestant), antipruritic effect; virtually no anticholinergic and antiserotoninergicheskogo action.
At therapeutic doses substantially no sedative action.
The action begins within 12 minutes after receiving a single dose in 50% of patients after 1 hour – 95% and
Pharmacokinetics:
The pharmacokinetics is linear. Quickly absorbed by ingestion; food intake does not affect the absorption of completeness, but reduces its speed. Bioavailability – 100%. The time to reach maximum concentration (TSmah) – 0.9 h, the maximum concentration (Cmax) – 207 ng / ml. The volume of distribution – 0.4 l / kg. Relationship to plasma proteins – 90%. Less than 14% of the drug is metabolized in the liver by O-dealkylation with a pharmacologically inactive metabolite. The half-life (T1 / 2) – 7-10 hours total clearance -. 0.63 ml / min / kg. Completely eliminated from the body within 96 hours. Excreted by the kidneys (85.4%). In renal failure (creatinine clearance less than 40 mL / min) clearance is reduced (in patients on hemodialysis – 80%), T1 / 2 -udlinyaetsya. Less than 10% removed during hemodialysis. It passes into breast milk.
Pregnancy and breast-feeding
Use of the drug is contraindicated in pregnancy, as controlled clinical trials on the safety of the drug in pregnant women have been conducted. If necessary, the drug during lactation is recommended to stop breast-feeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Used parameters less than the frequency of side effects are defined as follows: very often:> 1/10; often:
special instructions
Suprastineks drops is not recommended for children under the age of 2 years due to insufficient data on the use of the drug.
The period of treatment is recommended to refrain from the use of ethanol.
Drops Suprastineks® can cause allergic reactions (sometimes later), because they contain methyl parahydroxybenzoate and propyl parahydroxybenzoate.
VLIYAENIE on ability to drive vehicles and management mechanisms
During treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
At temperatures above 25 ° C. Do not freeze.
Keep out of the reach of children.
An open bottle stored no longer than 6 weeks.
Dosing and Administration
For ingestion. The drug should be taken at meal time or on an empty stomach. The required number of drops to be metered using a dropper in tablespoon or water glass. Drops should be taken orally immediately after dilution. The daily dose is recommended to take at one time.
The recommended dose for adults and children over 6 years of age, older patients (assuming normal renal function) – 5 mg (1 ml drops or droplets 20 of the dropper) per day. The maximum daily dose should not exceed 5 mg.
Children aged 2 to 6 years – the daily recommended dosage is 2.5 mg for receiving two equal doses of 1.25 mg (2 x 0.25 ml = 2×5 droplet drops from a dropper). The maximum daily dose should not exceed 2.5 mg.
Patients with impaired renal function
Periodicity reception should be set individually according to renal function. In patients with chronic renal failure with creatinine clearance (CC) of 30 to 49 ml / min the dose should be reduced by 2 (5 mg (1 ml drops or droplets 20 of the dropper) every other day); with CC from 10 to 29 ml / min the dose should be reduced to 3 times (for 5 mg (1 ml drops or droplets 20 of the dropper) every 3 days). In severe renal failure (creatinine clearance less than 10 mL / min), the drug is contraindicated.
Patients with impaired liver function
In appointing the drug to patients with isolated hepatic impairment, no dose modification is required. Patients with combined dysfunction of liver and kidney recommended dosage adjustment (see. The above section “Patients with impaired renal function”).
The duration of the drug
The duration of administration depends on the disease.
In the treatment of persistent allergic rhinitis (symptoms
treatment of hay fever is on average 1-6 weeks. In chronic diseases (perennial rhinitis, chronic idiopathic urticaria) treatment can be increased. There is clinical experience with the drug up to 6 months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

EGIS

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