Pentalgin Tab n / a film about 24 pc


Pentalgin Tab n / a film about 24 pc



Active substance:
1 tablet contains: Paracetamol – 325 mg naproxen – 100 mg Anhydrous caffeine – 50 mg, drotaverine hydrochloride – 40 mg, pheniramine maleate – 10 mg.
Microcrystalline Cellulose – 128.0000 mg, potato starch – 55.3800 mg, croscarmellose sodium – 32.0000 mg, giproloza (hydroxypropyl) – 32.5200 mg citric acid monohydrate – 3,0000 mg, butylhydroxytoluene (E 321) – 0 , 3000 mg of magnesium stearate – 7.2000 mg talc – 16.1200 mg dye quinoline yellow (E 104) – 0.4608 mg, indigo carmine (E 132) – 0.0192 mg
Coating: Hypromellose (hydroxypropyl) – 12.1700 mg, povidone (polyvinylpyrrolidone middle molecular medicine, povidone K25) – 3.8700 mg polysorbate-80 (Tween-80) – 1.1000 mg of titanium dioxide – 3.4300 mg talc – 4.2180 mg dye quinoline yellow (E 104) – 0.2000 mg, indigo carmine (E 132) – 0.0127 mg or
Sheath Opadry Green 13A210001 (OPADRY 13A210001 GREEN) – 25,0007 mg [hypromellose – 12.1700 mg Povidone – 3.8700 mg polysorbate-80 -1.1000 mg, titanium dioxide – 3.4300 mg talc – 4, 2180 mg, quinoline yellow – 0.2000 mg, FD & C blue # 2 / indigo carmine – 0.0127 mg].
Tablets, film-coated from light green to green, biconcave capsule-shaped with beveled edges, with the mark on one side and on the other embossing PENTALGIN. On a section of the tablet is light green with white patches.
Product form:
Tablets, film-coated.
At 2, 4, 6, 10 or 12 tablets in blisters of PVC film and aluminum foil printed patent. 1 or 2 blisters together with instructions for use in a pile of cardboard.
Increased sensitivity to the drug, erosive and ulcerative lesions of the gastrointestinal tract (exacerbation), gastrointestinal bleeding, the complete or partial combination of asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs, including including a history of severe hepatic and / or renal failure, inhibition of bone marrow hematopoiesis, condition after coronary artery shunt Ania; heavy organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent premature ventricular beats, severe arterial hypertension, hyperkalemia, children under 18 years, pregnancy and lactation.
Precautions – cerebrovascular disease, diabetes mellitus, peripheral arterial disease, ulcerative lesions of the gastrointestinal tract in history, renal and hepatic insufficiency mild or moderate severity, viral hepatitis, alcoholic liver disease, benign hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor ), epilepsy and susceptibility to seizures, lack of glucose-6-phosphate dehydrogenase, old age.
If you have one of these diseases / conditions before taking this medication, you should consult with your doctor.
Pain syndrome of various genesis, including pain in the joints, muscles, sciatica, menstrual pain, neuralgia, dental pain and headache (including headache due to cerebral vasospasm).
Pain syndrome associated with spasm of smooth muscles, including those with chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic.
Post-traumatic and postoperative pain, including those accompanied by inflammation.
Catarrhal diseases accompanied by fever syndrome (as symptomatic therapy).
Interaction with other drugs
simultaneous administration of the drug should be avoided with barbiturates, tricyclic antidepressants, rifampicin and alcoholic beverages (increased risk of hepatotoxicity).
Paracetamol enhances the effect of indirect anticoagulants and reduces the efficiency of uricosuric drugs.
Prolonged use of barbiturates, reduces the effectiveness of paracetamol.
Concomitant use of paracetamol with ethanol increases the risk of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity paracetamol.
Diflunisal increases the plasma concentration of paracetamol at 50%, which increases the risk of hepatotoxicity.
Naproxen may cause a decrease in diuretic effect of furosemide, enhancement of the effect of indirect anticoagulants, sulfonamides and increases the toxicity of methotrexate, reduces the excretion of lithium and increases its concentration in blood plasma.
When the joint application of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) may increase the metabolic clearance and increased caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin – reduction of caffeine metabolism in the liver (slowing down its clearance and increase in blood concentration).
Simultaneous use of caffeine-containing beverages and other agents stimulating the central nervous system may lead to over-stimulation of the central nervous system.
With simultaneous use of drotaverine may weaken the antiparkinsonian effect of levodopa.
When applied simultaneously with pheniramine tranquilizers, hypnotics, monoamine oxidase inhibitors, alcohol may increase inhibitory effect on the central nervous system.
Symptoms: pale skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia (increased body temperature), frequent urination, headache, tremor or muscle twitching; seizures, increased activity of “hepatic” transaminases, gepatonekroz, increased prothrombin time. Symptoms of liver function may occur through 12-48 hours after the overdose. In severe overdose of developing liver failure with progressive encephalopathy, coma, and death; Acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, immediately seek medical help.
Treatment: gastric lavage followed by administration of activated charcoal. A specific antidote for poisoning by paracetamol is acetylcysteine. Introduction acetylcysteine ​​important for 8 hours at gastrointestinal bleeding must administering antacid and gastric lavage with ice-cold 0.9% sodium chloride solution.; maintain ventilation and oxygenation; epileptic seizures – intravenous diazepam; maintaining the fluid balance and salts.
pharmachologic effect
Pharmacological group:
Analgesics (non-narcotic analgesic non-steroidal anti-inflammatory agent + drug + psihostimulirutee antispasmodic agent + + H1-histamine receptor blocker).
Pharmacological properties:
Combined preparation has analgesic, anti-inflammatory, antispasmodic, analgesic action.
Paracetamol – a non-narcotic analgesic, has antipyretic and analgesic effect due to blockade of the cyclooxygenase in the central nervous system and the effects on pain centers and thermoregulation.
Naproxen – a non-steroidal anti-inflammatory drug, anti-inflammatory, analgesic and antipyretic effects associated with non-selective inhibition of cyclooxygenase activity that regulates the synthesis of prostaglandins.
Caffeine – causes vasodilation of skeletal muscle, heart, kidney; It increases mental and physical performance, helps eliminate fatigue and drowsiness; gistogematicheskih increases permeability barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on cerebral blood vessels.
Drotaverinum – myotropic has antispasmodic effect due to the inhibition of phosphodiesterase IV of, acts on the smooth muscle in the gastrointestinal tract, biliary tract, urinary and circulatory systems.
Pheniramine – blocker of H1-histamine receptors. Has spasmolytic and slight sedative effect, reduces the phenomenon of exudation, but also enhances analgetic action of Paracetamol and naproxen.
Pregnancy and breast-feeding
The drug is contraindicated during pregnancy. If necessary, use during lactation should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions: skin rash, pruritus, urticaria, angioedema;
From the side of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;
From the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration;
With the cardiovascular system: heart rate, arrhythmia, high blood pressure;
From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, abnormal liver function;
From the urinary system: renal dysfunction;
From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma;
Other: dermatitis, tachypnea (rapid breathing).
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
Avoid the simultaneous application of the drug with other agents containing paracetamol and / or other non-steroidal anti-inflammatory drugs, as well as with means to alleviate symptoms, “cold”, influenza and nasal congestion.
In applying the drug over 5-7 days should be monitored indicators of peripheral blood and functional state of the liver.
Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
If necessary, definition of 17-ketosteroids drug should be discontinued 48 hours before the study. Note that naproxen increases bleeding time.
The impact of caffeine on the central nervous system depends on the type of the nervous system and can manifest as excitation and inhibition of the higher nervous activity.
During treatment should not drink beverages containing alcohol.
The effect on the ability to operate vehicles, machinery
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Drugs are taken 1 tablet 1-3 times a day. The maximum daily dose – 4 tablets.
Duration of treatment is not more than 3 days as antipyretic and not more than 5 days – as an analgesic. Continuation of treatment is possible only after consultation with your doctor.
Do not exceed the indicated dose !.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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