Regeyn foam naruzhn.prim I-5% 60ml vial 3 pcs

Description

Composition
Active substance:
1 g of a foam comprises: Minoxidil – 47.50 mg * ;.
Excipients:
Anhydrous Ethanol – 536.30 mg Purified water – 314.10 mg BHT – 0.90 mg ** lactic acid – 10.00 mg anhydrous citric acid – 1.00 mg Glycerol – 20.00 mg cetyl alcohol – 11.00 mg stearyl alcohol – 5.00 mg, polysorbate 60 – 4.00 mg;
propellant – propane / n-butane / isobutane (%) (48: 30: 22) – 50.20 mg.
* The actual amount of minoxidil, without propellant is 50.00 mg / g; ** actual amount of butylated hydroxytoluene, without propellant, is 1.00 mg / g.
Description:
Foam from white to yellowish-white in color, preserving the structure during the observation period is one minute.
Product form:
An aerosol for external use 5%.
60 g of product in an aluminum aerosol container. The aerosol container equipped with a spray valve and cap to protect the system from opening children.
1 or 3 aerosol container together with instructions for use with a polymeric package protection system of opening children.
Contraindications
Hypersensitivity to minoxidil or other components of the formulation; violation of integrity of the skin; dermatoses of the scalp; concurrent use of other drugs on the scalp; pregnancy; breastfeeding; age: younger than 18 and older than 65 years.
Carefully:
Patients with cardiovascular disease and arrhythmia, renal and hepatic impairment before treatment with Regeyn® should consult a doctor.
Dosage
5 %
Indications
Treatment of androgenetic alopecia in men and women.
Interaction with other drugs
There is a theoretical possibility of strengthening of orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, not received, however, the clinical confirmation.
We can not exclude a very small increase in the content of minoxidil in the blood of patients suffering from hypertension and taking minoxidil inside in case of simultaneous use Regeyn® drug, although the corresponding clinical studies have not been conducted.
Established that minoxidil for topical application may interact with some other drugs for external application.
When applied topically minoxidil should not be used simultaneously with any other drugs (corticosteroids, tretinoin, anthralin), applied to the scalp. Simultaneous use of aerosols for topical application of minoxidil and a cream containing betamethasone (0.05%), leads to lower systemic absorption of minoxidil. Simultaneous use of a cream containing tretinoin (0.05%), leads to an increased absorption of minoxidil. Simultaneous application of minoxidil to the skin and formulations for external application such as dithranol and tretinoin, which cause changes in the protective functions of the skin, can lead to increased absorption of minoxidil.
Overdose
If doses exceeding recommended, applied to more extensive areas of the body or other parts of the body besides the scalp, may increase systemic absorption of minoxidil, which may lead to the development of adverse events. Signs and symptoms of overdose may be undesirable side effects of the cardiovascular system associated with sodium and water retention, and tachycardia, decreased blood pressure and dizziness.
Treatment is symptomatic and supportive.
For the treatment of tachycardia can be assigned to beta-blockers, to eliminate edema – diuretics.
In the case of reducing the blood pressure should be introduced intravenously 0.9% sodium chloride solution. Should not be applied sympathomimetic drugs, such as epinephrine and norepinephrine, having a cardio excessive activity.
pharmachologic effect
Pharmacological group:
A treatment for alopecia.
Pharmacodynamics:
As a peripheral vasodilator, with topical minoxidil enhances microcirculation in the hair follicles. Minoxidil stimulates vascular endothelial growth factor (VEGF), which is supposed to be responsible for the increased permeability of the capillaries, which indicates a high metabolic activity observed in the anagen phase.
Minoxidil stimulates hair growth in patients with hereditary hair loss (androgenic alopecia) and moderate in the initial stage. The exact mechanism of action of minoxidil for topical application for hair loss is not fully understood.
Pharmacokinetics:
Suction
When applied topically to intact skin of approximately 1% minoxidil solution undergoes systemic absorption.
In a clinical study, systemic absorption is 5% aerosol for external use was approximately half the systemic absorption of 5% solution for external use. Average values ​​of area under the curve “concentration-time» AUC (0-12 h) and maximum concentration (Cmax) when using 5% aerosol made nghch 8.81 / ml and 1.11 ng / ml, respectively, corresponding to about 50% similar indicators when using a 5% solution (18.71 nghch / ml and 2.13 ng / ml, respectively).
The time to reach maximum concentration of minoxidil (TCmax) when using 5% aerosol is 5.42 h and is similar to that when using a 5% solution (5.79 h). Effect of minoxidil on hemodynamics is not expressed as long as the average serum concentration of minoxidil reaches 21.7 ng / ml.
Distribution
While the previously it reported that minoxidil does not bind to plasma proteins, in vitro later by ultrafiltration demonstrated its reversible binding to human plasma proteins in the range 37-39%.
Because only 1-2% absorbed topically applied minoxidil, the degree of binding to plasma proteins, notes in vivo after topical application, will be clinically significant.
The volume of distribution of minoxidil after intravenous administration at a dose of 4.6 mg and 18.4 mg of 73.1 L and 69.2 L, respectively.
Metabolism
Approximately 60% of minoxidil absorbed after topical application of minoxidil is metabolized to form a glucuronide, mainly in the liver.
breeding
The half-life of minoxidil for topical application of an average of 22 hours, compared to 1.49 hours upon oral administration. 97% minoxidil and its metabolites are excreted by the kidneys and 3% – through the intestine.
After termination of the drug about 95% of minoxidil applied externally is displayed for 4 days.
Pregnancy and breast-feeding
Regeyn® drug in aerosol form is contraindicated during pregnancy and lactation.
Conditions of supply of pharmacies
Without recipe.
side effects
The frequency of adverse reactions is given by the following grading: very often (> 1/10); common (> 1/100,
special instructions
Recommendations for use of the drug in conjunction with the means of hair care products:
The drug will not be effective when used: spray dryer after applying to the scalp; means on care of hair, which can cause scarring and deep burns of the scalp; methods of hair care products that require a strong pull hair from the scalp (for example, weaving “tight” braid (Brading) or hair “ponytail”).
For the application of the drug is not necessary to wash the head. When washing the hair before applying the drug, it is necessary to dry hair and scalp.
When using styling products, you must first apply spray and wait until it dries, and then use hair styling products.
Shampoo be not less than 4 hours after applying the drug.
Data on the effect of coloring, perms, straighteners hair on the effectiveness of the drug is not. Since perming and dyeing may cause irritation of the scalp, the following precautions are recommended:
Before staining and / or perm is necessary to ensure that the drug was washed out from the hair and scalp, to avoid possible scalp irritation.
For best results, do not apply the drug in one day with a chemical hair treatment.
After using any chemical substances are applied to the drug for 24 hours to ensure that the scalp is irritated not permed and / or staining.
Before starting treatment with Regeyn®, patients must undergo a general examination, including the collection and study of medical history. The physician should make sure that the skin of the scalp is healthy scalp.
Apply Regeyn® drug should only be on a healthy scalp. You can not use it with the inflammation, infection, irritation, skin tenderness, as well as in conjunction with other drugs applied to the skin of the scalp.
You should not use the drug Regeyn® in cases of sudden hair loss, alopecia areata, alopecia when developing after birth, in the case of hair loss caused by taking medications, malnutrition (iron deficiency, vitamin A), as a result of hair styling in the “tight” haircuts and in the case where the cause of hair loss is unknown.
When the blood pressure lowering or chest pain, palpitations, weakness or dizziness, sudden unexplained weight gain, edema of the hands or feet, persistent redness or irritation of the scalp discontinue use Regeyn® drug and consult a doctor.
Some components of the drug can cause burning and irritation. In case of contact of the drug with sensitive surfaces (eye, irritated skin, mucous membranes) must be washed with large quantities of cold water. The preparation contains butylated hydroxytoluene, cetyl and stearyl alcohol which may cause local skin reactions (e.g., contact dermatitis).
Random drug reception inside can lead to serious adverse events from the heart. Therefore, this drug should be stored out of the reach of children.
The contents of the aerosol container is pressurized. Do not pierce or burn the aerosol can. The drug is highly flammable, however, do not spray the contents of the aerosol container on an open flame, polished or painted surfaces. Avoid contact aerosol container with flames in use, storage and disposal. Do not heat above the balloon 50 ° C. When applying the drug should avoid smoking.
If the drug has come into disrepair or expiration date – do not pour it into the waste water and not be thrown into the street! Place the drug in the bag and place in the trash. These measures will help protect the environment!
In connection with the possible development of headaches, dizziness, eye irritation should be careful when driving and the particular activities that require high concentration and fast motor responses. When the described adverse events should refrain from carrying out these activities.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. Before using the drug Regeyn® hair and skin of the scalp should be thoroughly dried. For the efficacy and achievements of the hair follicles is important to put the drug on the skin of the scalp, not the hair.
The dose for men: 1 g (half cup) spray applied 2 times a day (morning and evening) to the affected areas of the scalp. Do not use Regeyn® more than 1 time in 12 hours. The total daily dose should not exceed 2 g product (100 mg minoxidil).
The dose for women: 1 g (half cup) aerosol applied 1 time a day to the affected areas of the scalp. You should not use the drug Regeyn® more than 1 time per day. The daily dose should not exceed 1 g product (50 mg minoxidil).
Do not apply the drug Regeyn® to other areas of the body.
Recommendations for the use of the spray can:
Turn the cap so that the arrow on the bottle and the cap are against each other.
Tilting the cap back, remove it.
Before extrusion aerosol recommended first fingers rinse with cold water and thoroughly dried, as by contact with the warm skin aerosol can dissolve.
Turning aerosol container upside down to press and squeeze dispenser fingers required amount of aerosol.
Distribute the spray tips of his fingers on the balding areas and gently rub into the scalp.
After use Regeyn® drug put on the aerosol can cap. To save the package protected against accidental opening of the children, make sure that the arrow on the bottle and cap were not aligned
After applying the product Regeyn® you must wash your hands thoroughly.
Suspending the first signs of hair loss and regrowth of hair possible after use of the medicinal preparation Regeyn® 2 times a day in men for 2-4 months, and 1 time per day in women for 3-6 months.
To achieve and maintain the achieved effect of hair regrowth patient should not interrupt the use of the drug, or hair loss resumes.
Increasing the dose or more frequent its application does not lead to better treatment results.
If after applying the drug Regeyn® men for 16 weeks and women for 24 weeks, increased hair growth is not observed, then the use of the drug should be discontinued.
After the introduction of medicament Regeyn® may experience increased hair loss. This effect is caused by the influence of minoxidil. It is expressed in stimulating hair transition from the resting phase (telogen) in growth phase (anagen). Thus, there is the old hair loss, on the spot where the new grow. Temporary increase of hair loss normally lasts for 2-6 weeks after starting treatment, and then decreases within two weeks.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist