Proproten 100 Table 40 pc

Description

Composition
Active substance:
Brain-specific proteins Antibodies to the S-100 affinity purified – 0.003
* Applied to the lactose as a water-alcohol mixture with a content not exceeding 10-1991 ng / g of the active form of the active ingredient.
Excipients:
0.267 g of lactose monohydrate, microcrystalline cellulose 0.03 g magnesium stearate 0.003 g
Description:
Tablets ploskotsilindricheskoy shape, with the notch and chamfer, from white to almost white color. On the flat side coated with Valium inscription MATERIA MEDICA, on the other flat side PROPROTEN label 100 applied.
Product form:
Lozenges. 20 tablets in blisters of PVC film and aluminum foil.
1 blisters together with instructions for medical application is placed in a pile of cardboard.
Contraindications
Increased individual sensitivity to the drug; pregnancy and lactation; age of 18 years; lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Indications
Exhibits anti-alcohol effect, reducing alcohol craving and reducing the likelihood of relapse.
Monotherapy with alcohol withdrawal syndrome of mild to moderate severity. The drug facilitates both psychiatric disorders (anxiety, mental stress, insomnia, irritability, anxiety, depressed mood, intense craving for alcohol) and somatovegetativnye disorders (weakness, sweating, headache, tremors, tachycardia, dyspepsia) alcohol “hangover” syndrome .
Interaction with other drugs
Incompatibilities with other drugs have not yet been identified.
Overdose
Accidental overdosing possible diarrheal phenomena caused by members of the formulation excipients.
pharmachologic effect
Pharmacological group:
Drugs used in alcohol dependence.
Pharmacodynamics:
Preparation modifies the functional activity of the protein S-100, carrying information in the brain conjugation and metabolic processes. Sensitizing neuronal membrane modulates synaptic plasticity of neurons. Provides modifying effect on the functional state of the brain structures involved in the formation of alcohol dependence:. Hypothalamus, hippocampus, etc. When alcohol dependency has a normalizing effect on positive emotional reinforcement system that reduces the frequency of self-stimulation of the lateral hypothalamus. Decreases bursting activity of neurons of the hippocampus; reduces the number of circulating immune complexes in the peripheral blood, which correlates with reduced ethanol consumption. Enhances the inhibitory effects of GABA in the CNS. It was established experimentally that the drug restores the neurotransmitter balance and the conditioned reflex activity. Increases resistance to cerebral hypoxia.
Pharmacokinetics:
Sensitivity modern physico-chemical methods of analysis (gas-liquid chromatography, high performance liquid chromatography, gas chromatography-mass spectrometry) does not allow to evaluate the content of the active components of the preparation Proproten 100 in biological fluids, organs and tissues, making it impossible technically pharmacokinetics study.
Pregnancy and breast-feeding
The drug Proproten-100 is contraindicated for use in women during pregnancy and breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Possible reactions of individual hypersensitivity to the drug.
special instructions
The preparation includes lactose monohydrate, and therefore it is not recommended for patients with congenital galactosemia, malabsorption of glucose, or with congenital lactase deficiency.
The effect on the ability to operate vehicles, machinery
During the treatment of alcohol withdrawal syndrome, given the specificity of the disease, should avoid car driving.
Storage conditions
At temperatures above 25 ° C.
Keep out of the reach of children.
During the period of the drug store contour cell pack in a cardboard bundle provided by the manufacturer.
Dosing and Administration
At one time – 1 tablet were kept in the mouth until complete dissolution – (not during a meal).
The hangover first 2 chasa drug take 1 tablet every 30 minutes; the next 8-10 hours – 1 tablet per hour. In the event of acceptance of sleep resumed after waking. Later in improvement drug taking 1 tablet every 2-3 hours (4-6 tablets per day) for 2-3 days. According to the doctor’s decision the drug can be used in the treatment: the weighting of symptoms of alcohol withdrawal is necessary to attach the drugs traditionally used in detoxification. For the prevention of relapse of drug taking 2 tablets per day for 6 months; after accidentally drinking to take an additional 2 tablets of the drug 2 times – day and night.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist