Erythromycin ointment Ch. 10000ed / g 10g tuba

Description

Composition
Active substance:
1 g of ointment contains: erythromycin (in terms of active ingredient) – 10 thousand.
U ;.
Excipients:
Lanolin (lanolin anhydrous) – 0.4 g; sodium bisulfite (sodium metabisulfite, sodium pyrosulfite) – 0.0001 g; Vaseline “for eye ointments” – up to 1 year
Product form:
10 thousand eye ointment.
U / g 3 g, 5 g, 10 g or laminated aluminum tubes. Each tube with instructions for use placed in a pile of cardboard.
Contraindications
Individual hypersensitivity to the drug, heavy human liver and kidney, a history of jaundice.
Carefully.
Advanced age, renal and hepatic function.
Indications
Eye infections caused by susceptible organisms: Conjunctivitis (including neonates), bacterial blepharitis, Blepharoconjunctivitis, meybomit; in the treatment of bacterial keratitis, chlamydial conjunctivitis, blepharoconjunctivitis, trachoma; prevention of ophthalmia neonatorum.
Interaction with other drugs
The drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism). It reduces the bactericidal activity of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems). Pharmaceutical incompatible with aminoglycosides. In use with corticosteroids leads to increase their effect.
Overdose
Data on overdose of the drug available.
pharmachologic effect
Pharmacological group:
Antibiotic, macrolide.
Pharmacodynamics:
Erythromycin – macrolide antibiotic produced by Streptomyces When applied topically, has antibacterial action. Reversibly binds to the 50S subunit of the ribosome, which disrupts the formation of peptide bonds between the molecules of amino acids, and blocks the synthesis of proteins of microorganisms (does not affect the synthesis of nucleic acids). When used in high doses, depending on the type of agent may exhibit bactericidal activity. Effective against susceptible microorganisms causing superficial ocular infection of the conjunctiva, the cornea, including against Neisseria gonorrhoeae, Chlamydia trachomatis.
Pharmacokinetics:
Absorbed into the aqueous humor and cornea of ​​the eye. When applied topically, low systemic absorption. Bioavailability was 30-65%. Distributed in most tissues and body fluids. Binding to plasma proteins is 70-90%. It is metabolized in the liver, partly to the formation of inactive metabolites. The half -. 1.4-2 hours Write intestines and kidneys.
Pregnancy and breast-feeding
Application of pregnancy is possible only in case of emergency, when the likely benefit to the mother outweighs the risk to the fetus. If necessary, the appointment during lactation should stop breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
Local reactions: redness, eye mucous membrane irritation, blurred vision, allergic reactions.
special instructions
Prior to the use of any other anti-acne agents for external application must wait at least 1 hour If over 3 -. 4 weeks acne condition does not improve, should consult a physician (to achieve a full therapeutic effect may take 2 – 3 months). In the prevention of neonatal ophthalmia should not wash erythromycin ophthalmic ointment from his eyes. Children whose mothers have symptomatic gonorrhea, erythromycin as an ophthalmic agent is used simultaneously with an aqueous solution of penicillin G for parenteral use.
Storage conditions
At a temperature not exceeding 25 C. Keep out of reach of children.
Dosing and Administration
Ointment for a lower eyelid in a strip length 1-1,3 cm 3 times a day.
Duration of treatment ophthalmia neonatorum, bacterial conjunctivitis, blepharitis, blepharoconjunctivitis, meybomita at keratitis combination therapy depends on the type and severity of the disease, but should not exceed 14 days.
In the treatment of trachoma – 4-5 times a day, the treatment should be combined with the opening of the follicle. When drug stihanii inflammatory process used 2-3 times per day. Duration of treatment of trachoma to 4 months.
In the treatment of chlamydial conjunctivitis lay ointment into the conjunctival sac of 4-5 times per day, the duration of treatment depends on the severity of the disease for up to 3 months.
To prevent Infections in newborns ointments strip length 0.5-1 cm for a lower eyelid once.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist