Polyoxidonium tab 12mg 10 pc

Description

Composition
Active substance:
Azoximer bromide – 12 mg;
Excipients:
mannitol – 3.6 mg Povidone K 17 – 2.4 mg lactose monohydrate – 185.0 mg Potato starch – 45.0 mg Stearic acid – 2.0 mg.
Description:
round, Valium Tablets white or white with a yellowish shade, with a facet, with Valium – on the one hand and with the inscription “IN” – on the other.
Product form:
Tablets, 12 mg
10 tablets in blisters of PVC film and aluminum foil. One or two contour cell packages together with instructions for use placed in a pile of cardboard.
Contraindications
– Increased individual sensitivity;
– pregnancy, breast-feeding;
– Children under 3 years of age;
– acute kidney failure;
– a rare hereditary intolerance to lactose, lactase deficiency, a syndrome of glucose-galactose malabsorption.
Carefully
If you have a disease, referred to in this section, contact your doctor before taking the drug:
chronic renal failure (apply no more than 2 times per week).
Dosage
12 mg
Indications
It is used in adults and children from 3 years of age for the treatment and prevention of acute and chronic respiratory disease in the stage of exacerbation and remission.
For treatment (combination therapy):
– acute and recurrent infectious exacerbations of chronic inflammatory diseases of the oropharynx, sinus, upper and lower respiratory tract, the inner and middle ear;
– allergies (including hay fever, bronchial asthma), complicated by recurrent – bacterial, fungal and viral infection;
For the prevention (monotherapy):
– recurrent herpetic infection and nasal labial;
– exacerbations of chronic lesions oropharyngeal infections, paranasal sinuses, upper respiratory tract, the inner and middle ear;
– secondary immunodeficiency states occurring due to aging or exposure to adverse factors.
Interaction with other drugs
Azoximer bromide does not inhibit isozymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450, and the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.
If you accept the above or any other medicines (including OTC), before taking polioksidoniya consult your doctor.
Overdose
Cases of overdose are not logged in.
pharmachologic effect
Pharmacological group:
immunomodulatory agent.
Pharmacodynamics:
Azoximer bromide has a complex action: immunomodulatory, detoxicating, antioxidant, anti-inflammatory moderate.
The basis for an immunomodulatory mechanism of action azoximer bromide is a direct effect on the phagocytic cells and natural killer cells, and stimulation of antibody synthesis and interferon-alpha and interferon-gamma.
Detoxification and antioxidant properties azoximer bromide is largely determined by the structure and nature of the high molecular weight of the drug.
Azoximer bromide increases resistance of the organism against both local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency, caused by different infection, trauma, complications after surgical procedures.
A characteristic feature in the local azoximer bromide (sublingual) use is the ability to activate the early defense against infection factors: drug stimulates bactericidal properties neutrophils, macrophages, enhances their ability to absorb bacteria improves the bactericidal properties of saliva and mucous secretions of the upper respiratory tract.
When administered orally as azoximer bromide activated lymphoid cells into lymph nodes intestine.
Azoximer bromide blocked soluble toxic substances and microparticles has the ability to excrete toxins, heavy metal salts, inhibits lipid peroxidation, both due to the interception of free radicals and by elimination of catalytic ions Fe2 +. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.
Azoximer bromide well tolerated, has no mitogenic, polyclonal activity, antigenic properties, has no allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
Azoximer bromide has no smell and taste, has no local irritating effect when applied to the mucous membranes of the nose and oropharynx.
Pharmacokinetics:
Azoximer bromide after ingestion is rapidly absorbed from the gastrointestinal tract, bioavailability in oral administration of more than 70%. The maximum plasma concentration is reached after 3 hours after ingestion. Pharmacokinetics azoximer bromide is linear (plasma concentration is proportional to the dose).
Azoximer bromide compound is hydrophilic. Apparent volume of distribution is about 0.5 L / kg, suggesting that the drug is distributed mainly in the extracellular fluid. poluabsorbtsii period – 35 minutes, half-life – 18 hours.
Azoximer bromide is rapidly distributed to all organs and tissues of the body, it penetrates the blood-brain and blood-barrier. The cumulative effect is not. In the body azoximer bromide undergoes biodegradation to low molecular weight oligomers derived primarily by the kidneys, with faeces – less than 3%.
Pregnancy and breast-feeding
Polioksidoniy® not use this drug to pregnant women and during breast feeding (clinical experience with offline).
In the experimental use of the drug Polioksidoniy® in animals revealed no embryotoxic and teratogenic effects, effects on fetal development.
Before applying Polioksidoniy® medication if you are pregnant or suspect that you might be pregnant, or planning to become pregnant, you must consult your doctor.
During the period of breast-feeding before using Polioksidoniy® drug should consult a doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Side effects were recorded.
If you notice any side effects not listed in the instructions, tell your doctor.
special instructions
With the development of allergic reactions should stop using Polioksidoniy® drug and consult a doctor.
If necessary Polioksidoniy® discontinuation cancellation can be carried out directly, without the gradual decrease in the dose.
In the case of missing the next dose administration subsequent its application should be performed in the normal mode, as indicated in the instructions or recommended by a doctor. The patient should not double the dose administered to compensate for missed doses.
Do not use the drug if there is visual evidence of his unfitness (stacking fault discoloration tablets).
Effects on ability to drive vehicles and other mechanisms
Use of the drug Polioksidoniy® does not affect the ability to perform potentially hazardous activities that require high concentration and speed of psychomotor reactions (including the management of vehicles, work with moving machinery).
Storage conditions
At a temperature of 2 to 25 ° C. Keep out of the reach of children.
Dosing and Administration
Use according to the drug only indications that the application and in those doses which are specified in the instruction.
If after treatment there is no improvement or symptoms are aggravated, or there are new symptoms, you should consult with your doctor.
Orally and sublingually for 20-30 minutes before meals daily, 2 times a day: children older than 10 years and adults – 1 tablet, children from 3 to 10 years – 1/2 tablet (6 mg).
If necessary, may conduct repeated courses of therapy in 3-4 months. When the re-appointment of the drug efficacy is not reduced.
The recommended treatment regimen
sublingual:
For the treatment of adults:
influenza and acute respiratory infections – 1 tablet 2 times daily for 7 days;
inflammatory oropharynx – 1 tablet 2 times a day for 10 days;
exacerbations of chronic respiratory diseases, paranasal sinuses, chronic otitis – 1 tablet 2 times a day for 10 days;
allergies (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infection – 1 tablet 2 times a day for 10 days.
For the treatment of children 3 to 10 years:
influenza and acute respiratory infections – 1/2 tablet 2 times daily for 7 days;
inflammation of the oropharynx – 1/2 tablets 2 times a day for 7 days;
allergies (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infection – 2 1/2 tablet twice a day during 7 days.
For the treatment of children over 10 years:
influenza and acute respiratory infections – 1 tablet 2 times daily for 7 days;
inflammatory oropharynx – 1 tablet 2 times a day for 7 days;
exacerbations of chronic respiratory diseases, paranasal sinuses, chronic otitis – 1 tablet 2 times a day for 7 days;
allergies (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infection – 1 tablet 2 times a day for 7 days.
For the prevention of adult:
influenza and acute respiratory infections in the pre-epidemic period – 1 tablet per day for 10 days;
recurrent herpes infections and nasal labial – 1 tablet 2 times a day for 10 days;
exacerbations of chronic lesions oropharyngeal infections, paranasal sinuses, upper respiratory tract, the inner and middle ear – 1 tablet once a day for 10 days;
secondary immunodeficiencies resulting from aging or exposure to adverse factors – 1 tablet 1 time a day for 10 days
For the prevention of children from 3 to 10 years:
influenza and acute respiratory infections in the pre-epidemic period – 1/2 tablet per day for 7 days;
recurrent herpes infections and nasal labial – 1/2 tablets 2 times daily for 7 days;
exacerbations of chronic infection foci oropharynx, sinus, upper respiratory tract, the inner and middle ear – 1/2 tablet once a day for 10 days.
For the prevention of children over 10 years:
influenza and acute respiratory infections in the pre-epidemic period – 1 tablet per day for 7 days;
recurrent herpes infections and nasal labial – 1 tablet 2 times daily for 7 days;
exacerbations of chronic lesions oropharyngeal infections, paranasal sinuses, upper respiratory tract, the inner and middle ear of 1 tablet once a day for 10 days.
orally
For the treatment of adults:
diseases of the upper and lower respiratory tract infections – 1 tablet with 2 times 10 days.
For the treatment of children over 10 years:
diseases of the upper and lower respiratory tract infections – 1 tablet with 2 times 10 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist