Pauerkort Cream 0.05% 15g tube

Description

Composition
Active substance:
100 g of ointment contains: clobetasol propionate – 0.05 g
Excipients:
Paraffin (paraffin soft white), liquid paraffin, cetomacrogol, sodium phosphate monohydrate, sodium phosphate dihydrate, butylhydroxytoluene, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water.
Description:
Uniform cream white.
Product form:
Cream for external use 0.05%.
15 g of the aluminum tube, the nozzle having a closed end with a lid having a cutting edge for puncturing.
Each tube together with instructions for use placed in a cardboard box.
Contraindications
– rosacea; – acne vulgaris; – skin cancer; – nodular pruritus Hyde; – perioral dermatitis; – perianal and genital itching; – bacterial, viral and fungal skin diseases (herpes simplex, chickenpox, lupus, actinomycosis, etc.); – a common plaque and pustular psoriasis; – hypersensitivity to active drug and excipients; – up to 1 year; – Lactation.
Dosage
0.05%
Indications
– psoriasis; – eczema (various forms); – lichen planus; – discoid lupus erythematosus; – Skin diseases that are resistant to therapy less active corticosteroids for topical use.
Interaction with other drugs
No data.
Overdose
The development of acute overdose unlikely. However, in the case of chronic overdose or misuse of hypercortisolism may develop symptoms that require the gradual withdrawal of the drug under medical supervision.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use.
Pharmacodynamics:
Glyukokorstikosteroid for external application. Warns accumulation of neutrophils boundary, reduces the inflammatory exudation and production of lymphokines inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, has a local anti-inflammatory, antipruritic, anti-allergic and anti-exudative effects.
Pharmacokinetics:
The average maximum concentration of clobetasol propionate is reached in plasma after 13 hours after the first application and after 8 hours after repeated application to healthy skin 30 g of clobetasol propionate 0.05% in the form of ointments and 0.63 ng / ml. After 10 hours after application of the second dose (30 g), clobetasol propionate in a cream its mean maximum plasma concentration slightly higher than that of ointments. After 3 hours after a single application of 25 g of 0.05% clobetasol propionate ointment in patients with psoriasis and eczema mean maximum drug concentration in plasma was 2.3 ng / ml and 4.6 ng / ml, respectively.
Systemic metabolism of clobetasol propionate after percutaneous absorption has not been studied.
Pregnancy and breast-feeding
Steroids for topical use should not be used during pregnancy for a long time in large doses.
Safety of application of clobetasol propionate during lactation has not been established.
Conditions of supply of pharmacies
By prescription.
side effects
Long term administration of corticosteroids for topical application in large doses or applying them to the vast areas of the skin may be accompanied by systemic absorption and the subsequent development of Cushing’s symptoms. The risk of this complication is elevated in children, especially in the application of occlusive dressings, and the diaper may serve as a bandage.
Provided destination Pauerkorta adult patients at a dosage of not more than 50 g per week, suppression of the pituitary and adrenal function has a smooth transient-recovery immediately after completion of treatment.
Prolonged treatment with highly active corticosteroids for topical application in high doses may cause atrophic changes of the skin, in particular its thinning, the appearance of stretch marks (striae), dilation of superficial blood vessels, especially when applied under occlusive dressings and applied the preparation on skin with wrinkles. May develop skin pigmentation and hypertrichosis. In rare cases of psoriasis glucocorticosteroid treatment for topical use (or cancel) provokes pustular psoriasis.
Sometimes Pauerkort can cause an aggravation of symptoms.
special instructions
Should be avoided glucocorticosteroids for topical administration for a long time, especially in the treatment of young children, as this can happen adrenal suppression.
Application Pauerkorta in children requires medical supervision at least once a week.
On the face more often than in other areas of the body may appear atrophic skin changes as a result of prolonged use of local glucocorticosteroids.
When applying the cream on the eyelids must be ensured that the drug is not hit in the eye, because it can cause glaucoma.
Treatment of psoriasis topical corticosteroids may be accompanied by the development of relapses, tolerance to the drug, generalized pustular forms of the disease, local or systemic toxic reactions due to violation of the skin barrier function, so it is particularly important close observation of the patient.
When joining a secondary infection should be appropriate antibiotic therapy. If any signs of generalized infection should stop the topical application of glucocorticosteroids and conduct appropriate treatment with antibacterial drugs.
Warm moist conditions created upon application of occlusive dressings, contribute to the emergence of a bacterial infection, so be sure to clean the skin before applying a new bandage. Cream is not recommended to plant.
Effects on ability to drive a car / machinery
It is unlikely that clobetasol propionate affect this ability.
Storage conditions
Store in a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Cream Apply a thin layer to the affected skin once or twice a day to get the effect. Treatment should not be spending more than 4 weeks without assessing the need for its continuation. For the treatment of exacerbations of skin diseases can be carried out repeated short courses Pauerkortom. If you want to continue therapy – corticosteroids, use less active drugs.
In a particularly resistant cases, especially in the presence of hyperkeratosis, lotions Pauerkort inflammatory effect may be enhanced by blending overnight on area of ​​the drug from the bandage of plastic film, which is usually accompanied by a positive effect. Subsequently the achieved effect can be maintained without the use of occlusive dressings.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist