Orvis Flu powder for solution inside 500mg + 200mg 25mg + 4.95g bags 4 pcs lemon / ginger

$3.94

Orvis Flu powder for solution inside 500mg + 200mg 25mg + 4.95g bags 4 pcs lemon / ginger

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SKU: 1616104216 Categories: , , Tags: ,

Description

Composition
Active substance:
1 sachet contains: paracetamol 500.00 mg 200.00 mg ascorbic acid, pheniramine maleate 25.00 mg.
Excipients:
Maltodextrin – 3507.25 mg; Aspartame – 24.75 mg; Sodium citrate – 247.50 mg; Citric acid anhydrous – 49.50 mg; lemon concentrate powder [lemon juice, maltodextrin, citric acid] – 247.50 mg; dry ginger extract [ginger root extract, starch, maltodextrin, colloidal silicon dioxide] – 49.50 mg; natural flavoring “Lemon” [aroma composition, natural flavoring component, maltodextrin, gum arabic] – 99.00 mg.
Description:
The granulated powder from light pink to yellowish white to light brown color with a characteristic smell of lemon and ginger. Allowed blotches of white, gray and brown. Presence of easily crumbling lumps.
The solution was light yellow with a pinkish or brownish tint, turbid, with the characteristic smell of lemon and ginger. Presence of undissolved particles from yellow to brown.
Product form:
powder for solution for oral administration [ginger lemon] 500 mg + 25 mg + 200 mg.
According to 4.95 grams in the bag of the film based on a combination of polymer films and aluminum foil (PET / F / PE).
4, 6, 10, 20 bags together with instructions for use in a pile of cardboard.
Contraindications
Hypersensitivity to paracetamol, ascorbic acid, pheniramine or any of the excipients.
Pregnancy and breast-feeding.
Erosive and ulcerative lesions of the gastrointestinal tract (exacerbation). Liver failure.
Closure glaucoma.
Urinary retention associated with diseases of the prostate and urination disorders.
Portal hypertension.
Alcoholism.
Phenylketonuria.
enzyme deficiency, glucose-6-phosphate dehydrogenase.
Age up to 15 years.
Carefully:
Renal failure (creatinine clearance
Simultaneously or within the previous 2 weeks receiving monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants. The simultaneous administration of drugs that can adversely affect the liver; in patients with bronchial asthma, chronic bronchitis, recurrent formation of uric acid kidney stones.
Indications
Used in acute respiratory infections, acute respiratory viral infections (ARVI), nasopharyngitis (rhinitis), influenza to facilitate the following symptoms: fever; chills; headache; nasal congestion; rhinorrhea; watery eyes; sneezing; pain in the muscles and joints.
Interaction with other drugs
Ethanol enhances the sedative effect of antihistamines (pheniramine), so avoid its reception during the treatment period. In addition, ethanol, while the use pheniramine promotes the development of acute pancreatitis. Pheniramine enhances the effect of sedative drugs: morphine derivatives, barbiturates, benzodiazepines and other anxiolytics, neuroleptics (meprobamate, phenothiazine derivatives), antidepressants (amitriptyline, mirtazapine, mianserin), antihypertensive drugs centrally acting sedatives, belonging to the group of H1-histamine blockers, baclofen ; thus not only increasing sedation, but also increases the risk of adverse drug events (urinary retention, dryness of the oral mucosa, constipation).
It should be taken into account the possibility of strengthening the central atropinopodobnye effects when used in combination with other substances having anticholinergic properties (other antihistamines, antidepressants, imipramine group, neuroleptic phenothiazine series, m-anticholinergic antiparkinsonian agents, atropine antispasmodics, disopyramide).
In applying the drug together with inducers of microsomal oxidation: barbiturates, tricyclic antidepressants, anticonvulsants (phenytoin), flumetsinolom, phenylbutazone, rifampicin and ethanol significantly increased risk of hepatotoxicity (due to the incoming of the paracetamol). Glucocorticosteroids while the application increases the risk of developing glaucoma.
Reception in conjunction with salicylate increases the risk of nephrotoxicity.
When applied simultaneously with chloramphenicol (chloramphenicol) increases the toxicity of the latter.
Paracetamol is contained in the formulation, enhances the effect of indirect anticoagulants and reduces the efficiency of uricosuric drugs.
Overdose
Signs of acute poisoning with paracetamol are anorexia, nausea, vomiting, epigastric pain, increased sweating, pale skin, drowsiness, metabolic acidosis (including lactic acidosis). overdose threshold may be reduced in elderly patients and children, patients taking certain medications (e.g., inducers of hepatic microsomal enzymes), alcohol or malnourished. After 1-2 days there are signs of impaired liver function. In severe cases, it develops liver failure, gepatonekroz, encephalopathy and coma, which can be fatal.
Signs of poisoning are pheniramine seizures, impaired consciousness, coma. When the symptoms of poisoning should immediately stop using the product and seek medical advice. Recommended gastric lavage, ehnterosorbentov (activated carbon, lignin hydrolysis), the purpose of antidote acetylcysteine ​​intravenously or orally (if possible, during the first 10 hours after the overdose), symptomatic treatment.
pharmachologic effect
Pharmacological group:
Means for removing the symptoms of acute respiratory diseases (ARD) and “cold” (non-narcotic analgesic agent + H1-histamine receptor blocker + vitamin).
Pharmacodynamics:
Combined preparation containing paracetamol, pheniramine and ascorbic acid.
Paracetamol – a non-narcotic analgesic, blocks cyclooxygenase, preferably in the central nervous system, affecting thermoregulation, and pain centers; It has analgesic and antipyretic effect.
Pheniramine – blocker H1-histamine receptors, rhinorrhea and epiphora reduces, eliminates spastic phenomena, edema and hyperemia of the nasal mucosa, nasal and paranasal sinuses.
Ascorbic acid is involved in regulating the redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, in the synthesis of steroid hormones; It reduces vascular permeability, reducing the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Paracetamol enhances portability and prolongs its effects (due to lengthening half-life (T1 / 2)).
Pharmacokinetics:
Paracetamol
After intake of rapidly absorbed from the gastrointestinal tract: the maximum concentration of drug in blood plasma are reached after 10-60 minutes. Is rapidly distributed to tissues of the body, it penetrates the blood-brain barrier. Communication with the plasma protein small and has no therapeutic value, but increases with the growth of the dose. Metabolism occurs in the liver, 80% of the dose reacts conjugation with glucuronic acid and sulphates to inactive metabolites; 17% undergoes hydroxylation to form 8 active metabolites, which is conjugated with glutathione to form already inactive metabolites. One of the hydroxylated intermediate metabolic product exhibits hepatotoxicity. This metabolite is detoxified by conjugation with glutathione, but it may be cumulated, and an overdose of paracetamol (acetaminophen 150 mg / kg acetaminophen or 10 g orally) to cause necrosis of hepatocytes. Excreted by the kidneys as metabolites, mainly in the form of conjugates. In the unchanged output of less than 5% of the dose. T1 / 2 is from 1 to 3 hours.
pheniramine
Almost completely absorbed in the digestive tract. T1 / 2 from the blood plasma is from 1 to 1.5 hours. Excreted predominantly through the kidneys.
Vitamin C
Absorbed in the small intestine. The bioavailability is approximately 70%. The time to reach maximum therapeutic concentration after ingestion – 4 hr. It is metabolized primarily in the liver. Excreted by the kidneys, through the intestines, sweat, unchanged and as metabolites.
Pregnancy and breast-feeding
In the absence of animal studies and clinical trials of the combination of acetaminophen, ascorbic acid and pheniramine during pregnancy, the drug is not recommended in this group of patients. It is not known whether the active ingredients of the drug in breast milk. The drug ORVIS® Flew during breastfeeding is not recommended. If necessary, the use of breast-feeding should be discontinued.
Conditions of supply of pharmacies
Without recipe.
side effects
The drug was well tolerated at the recommended doses. There are:
The dryness of the oral mucosa.
Nausea, vomiting, abdominal pain, constipation.
urination disorder.
Allergic reactions (erythema, skin rash, pruritus, urticaria, angioneurotic edema, anaphylactic shock).
Bronchospasm.
Drowsiness, disturbance of accommodation, palpitations, orthostatic hypotension, dizziness, loss of coordination, tremors.
Agitation, nervousness, insomnia, confusion, hallucinations, impaired concentration (often – in elderly patients), mydriasis.
Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), acute generalized exanthematous pustulosis.
Hepatotoxicity, nephrotoxicity.
Anemia, leukopenia, agranulocytosis, thrombocytopenia.
When the adverse reaction, stop taking the drug and consult a doctor.
special instructions
The preparation contains no sugar and can be used by patients with diabetes. The drug should not be used concomitantly with other drugs containing acetaminophen.
To avoid liver toxicity of paracetamol should not be combined with the admission of alcoholic beverages, as well as to make patients prone to alcohol abuse.
The risk of liver damage increases in patients with alcoholic hepatitis.
When exceeding the recommended doses and long-term use may occur psychological dependence on the drug.
To avoid an overdose of paracetamol, be sure that the total daily dose of acetaminophen contained in all medications taken by the patient, does not exceed 4 g
Effects on ability to drive vehicles, mechanisms:
Given the possibility of such undesirable effects like drowsiness and dizziness, in the period of treatment is recommended to refrain from performing potentially hazardous activities that require high concentration and psychomotor speed reactions (control cars and other vehicles, work with moving machinery, the work manager, operator etc.).
Storage conditions
At a temperature of not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside 1 sachet 2-3 times per day. Before use, the contents of one sachet dissolved in a beaker (200 ml) of hot water (50-60 C). If necessary, add sugar. Flew ORVIS® drug can be taken at any time of the day, but the best effect brings the drug before going to sleep at night.
The maximum daily dose was 4 g paracetamol (8 sachets) with a body weight of 50 kg.
The interval between doses of the drug should be at least 4 hours.
In patients with impaired renal function (creatinine clearance
The maximum duration of treatment – 5 days.
If there is no relief of symptoms within 5 days after receiving the drug, there remains elevated body temperature or after initial drop it suddenly rises again, you must consult your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

EVALAR

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