Papaverine hydrochloride 20 ms tab piece 40mg

Description

Composition
Active substance:
1 tablet contains: papaverine hydrochloride 40 mg ;.
Excipients:
Sucrose – 236.5 mg Starch – 70 mg Calcium stearate – 3.5 mg.
Description:
White scored tablet.
Product form:
Tablets of 40 mg per pack of 10 pieces.
10 tablets in a contour bezgyachakova package made of paper coated.
10 tablets in blisters of PVC film and aluminum foil or paper printed with lacquer polymeric coating. 1, 2, 3, 5, 10 or contour bezgyachakova of cellular packages with instructions for use placed into the package.
Outlined packaging together with an equal number of instructions for use placed in multipacks.
Contraindications
– hypersensitivity; – atrioventricular block; – glaucoma; – severe hepatic impairment; – old age (the risk of hyperthermia); – Children’s age (up to ten years).
Precautions are administered to subjects after traumatic brain injury, chronic renal failure, adrenal failure, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.
Dosage
40 mg
Indications
Papaverine used spasms of smooth muscle: – abdominal organs (cholecystitis, pylorospasm, spastic colitis, renal colic); – peripheral vascular (endarteritis); – cerebral vessels; – vessels of the heart – angina (in the complex therapy); – bronchospasm.
As an auxiliary medicament for sedation.
Interaction with other drugs
May increase the hypotensive effect of papaverine when combined with tricyclic antidepressants procainamide, reserpine, quinidine.
Papaverine spasmolytic effect is enhanced by the simultaneous use of barbiturates
With simultaneous use of papaverine reduces antiparkinsonian effect of levodopa and methyldopa hypotensive effect.
Overdose
Symptoms of overdose: double vision, weakness, decreased blood pressure, drowsiness.
Treatment: symptomatic (blood pressure maintenance).
pharmachologic effect
Pharmacological properties:
Antispasmodic, it has a hypotensive effect. Inhibits fosfodieste-once, cause accumulation within the cell cyclo-adenosine monophosphate and reduction of Ca2 +; It reduces the tone and relaxes the smooth muscles of internal organs (gastrointestinal tract, respiratory and urogenital systems) and vessels. In large doses, it reduces the excitability of the heart muscle and slows intracardiac conduction. Effects on the central nervous system is weak (in large doses has a sedative effect-ny).
Pharmacokinetics:
The absorption depends on the dosage form. Bioavailability on average – 54%. Relationship to plasma proteins – 90%. Well distributed, it penetrates the blood-tissue barriers. It is metabolized in the liver. The half – 0.5-2 hours (can be extended to 24 hours). Excreted by the kidneys in the form of metabolites. Completely removed from the blood by hemodialysis.
Pregnancy and breast-feeding
During pregnancy and lactation, the safety of the drug has not been established.
Conditions of supply of pharmacies
Without recipe.
side effects
For the skin: allergic reactions.
On the part of the digestive tract: constipation, increased activity of “liver” transaminases.
Cardio-vascular system: atrioventricular block, ventricular premature beats, blood pressure reduction.
From the hematopoietic system: eosinophilia.
Central nervous system: somnolence.
special instructions
During treatment reception of ethanol should be removed. Vasodilating action of the drug decreases with tobacco smoking.
Storage conditions
In a dry place, protected from light at a temperature not higher than 25 C.
In the reach of children.
Dosing and Administration
Papaverine is taken orally 40-60 mg 3-4 times a day (adult). The highest single dose – 200 mg daily – 600 mg. Children aged 10-14 years – 20 mg (1/2 tablet).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist