Niacin – solofarm injection 1% 1ml amp 10 pcs


Niacin – solofarm injection 1% 1ml amp 10 pcs

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Active substance:
1 ml of solution contains: 10 mg of nicotinic acid.
Sodium hydrogen carbonate until pH 5,0-7,0, water for injections to 1 mL.
Transparent colorless liquid.
Product form:
Injectable solution 10 mg / ml.
To 1 ml ampoules made of colorless or colored glass.
5 or 10 vials in blisters of PVC film and a polymer film, with or without a polymer film, or in the form of cardboard with cells for stacking ampoules.
1 the contour cellular packaging made of cardboard or form with 10 ampoules or blisters 2 or shapes from a cardboard of 5 ampoules together with instructions for use and a lancet ampulnam or without pricking the ampoule in a stack of cardboard.
Hypersensitivity to the drug, severe arterial hypertension, atherosclerosis, gout, hyperuricemia, hepatitis, decompensated diabetes, gastric ulcer and duodenal ulcer (in the acute stage), children’s age (18 years).
Hemorrhage, glaucoma, hepatic failure, hypotension, hyperacid gastritis, gastric ulcer and duodenal ulcer (non-acute stage).
10 mg / ml
Avitaminosis PP (pellagra).
Combined therapy: ischemic stroke; obliterative vascular disease of limbs (occlusive disease, Raynaud’s disease); neuritis of the facial nerve.
Hartnupa disease (an inherited disease with malabsorption of certain amino acids, including tryptophan).
Interaction with other drugs
Care must be taken when combined with antihypertensives, anticoagulants and acetylsalicylic acid. Nicotinic acid reduces the toxicity of neomycin and prevents them induced decrease in the concentration of cholesterol and high density lipoprotein. When combined with a sulfonylurea may raise blood glucose levels. When administered with lovastatin increases the risk of myopathy.
Overdose is unlikely due to the low toxicity of the drug. Nicotinic acid in patients with individual intolerance can cause reddening of the face and upper body, dizziness, hot flashes, urticaria, paresthesia (numbness, loss of sensation, tingling, pins and needles).
Treatment: symptomatic.
pharmachologic effect
Pharmacological group:
Niacin – a water-soluble B vitamin, compensates the deficit of vitamin PP (vitamin B3) is a specific protivopellagricheskimi means (avitaminosis vitamin PP). It has vasodilating effect on the level of small vessels (including the brain), improves, has a weak anticoagulant effect, activates fibrinolysis system. It has antiatherogenic properties.
When parenteral administration is rapidly distributed in the body tissues. It accumulates mainly in the liver and in the fatty tissue and the kidney. In the liver, nicotinic acid is converted to an amine, which is embedded in the nicotinamide adenine dinucleotide (NAD), which is a prosthetic group of enzymes that carry hydrogen and exercising redox processes. The major metabolites are N-methyl-2-piridon3-carboxamide and N-methyl-2-pyridone-5-carboxamide having no pharmacological activity. It can be synthesized in the intestine by bacterial flora of the incoming dietary tryptophan (60 mg tryptophan formed nicotinic acid 1 mg) in cooperation with pyridoxine (vitamin B6) and riboflavin (vitamin B2). The half-life – 45 minutes. Excreted by the kidneys in unchanged form and as metabolites, high doses – mostly unchanged. Renal clearance depends on nicotinic acid in blood plasma and can decrease it at a high concentration in plasma.
Pregnancy and breast-feeding
Taking into account the injectable route of administration of the drug, its side effects, use during pregnancy is strictly prescribed by a doctor, if the effect of therapy for the mother outweighs the potential risk to the fetus. If necessary, use during lactation, breast-feeding should be discontinued.
Conditions of supply of pharmacies
side effects
Cardio-vascular system: the feeling of “high tide” of blood to the scalp, redness of the face and upper body with a feeling of tingling and burning, with the rapid introduction – lowering blood pressure, orthostatic hypotension, collapse.
On the part of the central nervous system and peripheral nervous system: paresthesia, dizziness.
From the digestive system: long-term use – fatty liver. On the part of metabolism: for prolonged use – hyperuricemia, impaired glucose tolerance, elevated blood levels of aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase.
Local reactions: pain at the site of subcutaneous and intramuscular administration.
Other: allergic reactions (skin rash, pruritus, stridor).
special instructions
During treatment should regularly monitor liver function. Prolonged use of nicotinic acid in high doses may develop fatty liver. For the prevention of hepatotoxicity is necessary to include in the diet foods rich in methionine (curds) or methionine appointment or other lipotropic agents.
The effect on the ability of control of vehicles and mechanisms
During treatment, it is recommended to refrain from driving and other activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
The drug used subcutaneously, intramuscularly, intravenously (slowly). When pellagra (avitaminosis PP) parenterally administered 1 ml of 1% (10 mg) of solution 1-2 times a day for 10-15 days.
In ischemic stroke slowly intravenously administered 10 mg of solution.
When disease Hartnupa: 40-200 mg per day.
For other indications mentioned in the section “Indications” 10 mg 1-2 times a day for 10-15 days.
The maximum dose for adults: single – 100 mg daily – 300 mg.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

Grotex Ltd.

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