N Tsitramon tab 20 pcs aveksima

Description

Composition
Active substance:
1 tablet contains: Acetylsalicylic acid – 240 mg paracetamol – 180 mg caffeine (calculated as the monohydrate) – 30 mg; ;.
Excipients:
Cocoa powder – 22.5 mg Citric Acid Monohydrate – 5.0 mg potato starch – 64.2 mg Talc – 4.9 mg Calcium stearate – 2.8 mg polysorbate-80 – 0.6 mg.
Description:
Tablets light brown with splashes, ploskotsilindricheskoy shape with the notch and chamfer with cocoa flavor.
Product form:
Tablets.
10 tablets in blisters.
30 tablets in a jar of polymeric materials.
1 or 2 blisters or 1 bank of polymer materials with instructions for medical application is placed in a pile of cardboard.
Contraindications
Increased sensitivity to the drug; erosive and ulcerative lesions of the gastrointestinal tract (exacerbation); gastrointestinal bleeding (including history); complete or partial combination of asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or non-steroidal anti-inflammatory drugs (including history); expressed by human liver and / or kidney; hemorrhagic diathesis, hypocoagulation, hemophilia, hypoprothrombinemia; pregnancy (I and III trimester); – the period of breast-feeding; surgery, accompanied by profuse bleeding; deficiency of glucose-6-phosphate dehydrogenase; glaucoma; severe hypertension; portal hypertension; severe coronary heart disease; beriberi K; Children under 15 years of age (the risk of Reye’s syndrome in children with hyperthermia on a background of viral diseases); irritability, sleep disturbances.
Precautions: Renal insufficiency mild to moderate, liver disease, alcoholism, epilepsy and susceptibility to seizures, advanced age, gout, pregnancy (II trimester).
Indications
Pain syndrome mild to moderate severity (different origins): headache, migraine, toothache, neuralgia, myalgia, arthralgia, tuberculosis. Feverish syndrome: acute respiratory infections, including influenza.
Interaction with other drugs
Potentiates the effect of heparin, anticoagulants, reserpine, steroid hormones and hypoglycemic drugs. The simultaneous use of other nonsteroidal anti-inflammatory drugs, methotrexate increases the risk of side effects.
Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs and medicines protivopodagricakih promoting excretion of uric acid.
Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other stimulants microsomal oxidation contribute to the formation of toxic metabolites of paracetamol affecting the liver function.
Metoclopramide accelerates the absorption of paracetamol.
Under the influence of paracetamol half-life (T1 / 2) chloramphenicol increases by 5 times. Repeated dose paracetamol may enhance the action of anticoagulants (bishydroxycoumarin).
Caffeine speeds up the absorption of ergotamine.
At the same time taking the drug and alcohol-containing liquids increases the risk of liver toxicity.
Overdose
Do not exceed the recommended dose or duration of use.
Overdose symptoms caused by acetylsalicylic acid.
Symptoms in mild intoxication: nausea, vomiting, stomach pain, dizziness, ringing in the ears; in severe intoxication: sedation, drowsiness, collapse, convulsions, shortness of breath, anuria, bleeding.
Treatment: gastric lavage using activated charcoal, symptomatic therapy, depending on the metabolic state – the introduction of sodium hydrogencarbonate, sodium citrate or sodium lactate, it increases the excretion of acetylsalicylic acid due to alkalization of urine.
pharmachologic effect
Pharmacological group:
Analgesic combined (NSAIDs are non-narcotic analgesic agent + + psychostimulant agent).
Pharmacological properties:
Combined preparation.
Acetylsalicylic acid has antipyretic and antiinflammatory action, reduces pain, especially caused by inflammation, as well as moderately inhibits platelet aggregation and thrombus formation, improves microcirculation in inflammation.
Paracetamol has analgesic, antipyretic and weak anti-inflammatory action, that is connected with its effect on hypothalamus thermoregulation center in mild and capable of inhibiting the synthesis of prostaglandins (Pg) in peripheral tissues.
Caffeine increases the excitability of spinal cord reflex, excites the respiratory and vasomotor centers, dilates blood vessels in skeletal muscle, brain, heart, kidneys, reducing platelet aggregation; reduces drowsiness, fatigue. This combination of caffeine in a small dose substantially no stimulating effect on the central nervous system, the brain but contributes to the regulation of vascular tone.
Pregnancy and breast-feeding
In pregnancy (I and III trimester) and during breastfeeding drug contraindicated. In the II trimester of pregnancy should be used with caution, correlating the expected benefit to the mother and the potential risk to the fetus.
Conditions of supply of pharmacies
Without recipe.
side effects
May experience adverse reactions that are typical of acetylsalicylic acid, acetaminophen and caffeine: anorexia, nausea, vomiting, gastralgia (platelet aggregation decrease), erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, allergic response, bronchoconstriction, exudative erythema multiforme ( including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), kidney failure, liver failure, dizziness, tachycardia, increased blood pressur and I.
With prolonged use may dizziness, headache, blurred vision, tinnitus, decrease platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.). Papillary renal damage with necrosis; deafness, Reye’s syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche hand, vomiting, liver dysfunction).
special instructions
Acetylsalicylic acid retards blood clotting. If the patient will have surgery, you should tell your doctor about taking medication.
Prolonged use of the drug requires monitoring of peripheral blood and functional state of the liver.
Patients with hypersensitivity reactions or wheeze to salicylic acid and its derivatives, including aspirin, may be administered only under special precautionary measures (in the emergency services).
In patients with a predisposition to the accumulation of uric acid, the drug can trigger a gout attack. During the reception should refrain from drinking alcohol (increased risk of gastrointestinal bleeding and liver toxicity).
Acetylsalicylic acid has a teratogenic effect; when used in the I trimester leads to congenital malformations – splitting the upper palate; in the III trimester – to inhibition of labor (synthesis inhibition Pg), the closure of the ductus arteriosus in the fetus, causing hyperplasia of pulmonary vascular hypertension and in blood vessels of the pulmonary circulation. Excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets.
Children under 15 years should not be prescribed drugs containing acetylsalicylic acid, as in the case of viral infection, they can increase the risk of Reye’s syndrome. Symptoms of Reye syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.
Impact on the management of vehicles and machinery service and mechanisms that require concentration:
No data on the influence to drive vehicles and to operate machinery and mechanisms that require concentration.
Storage conditions
Stored in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
Inside (during or after meals), 1 tablet every 4 hours while pain syndrome – 1-2 tablets; the average daily intake – 3-4 tablets, maximum daily dose – 8 tablets.
The product has no more than 7-10 days. To reduce the irritant effect on the gastrointestinal tract, the tablet should be taken with milk or alkaline mineral water.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist