Nurofen Express neo pi n / 200mg about 12 pc

$3.06

Nurofen Express neo pi n / 200mg about 12 pc

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Description

Composition
Active substance:
Sodium ibuprofen dihydrate 256 mg (equivalent to 200 mg ibuprofen)
Excipients:
croscarmellose sodium, xylitol, microcrystalline cellulose, Magnesium Sterate, colloidal silicon dioxide. shell composition: carmellose sodium, talc, gum acacia, sucrose, titanium dioxide (E171), macrogol 6000, black ink [Opakod S-1-277001].
Description:
Round biconvex tablets, coated white color with black color overprint “N” on one side of the tablet.
Product form:
Coated tablets of 200 mg.
6 or 12 tablets in a blister (PVC / PVDC / Aluminum).
1 (12 pieces) 2 blisters or (6 pieces) are placed in a cardboard box, together with instructions for use.
Contraindications
– Hypersensitivity to ibuprofen or any of the components included in the formulation.
– full or partial combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (including history).
– erosive and ulcerative diseases of the gastrointestinal (including gastric ulcer and duodenal ulcer disease, Crohn’s disease, ulcerative colitis) or ulcer bleeding in the active phase or in history (two or more episodes of proven peptic ulcer or bleeding ulcer).
– Bleeding ulcer or perforation of the gastrointestinal tract in history, triggered by the use of NSAIDs.
– Severe liver failure or liver disease in active phase.
– Renal nedostatochnost’tyazheloy severity (creatinine clearance
– decompensated heart failure; period after coronary artery bypass grafting.
– Cerebrovascular or otherwise krovotechenie.Neperenosimost fructose, glucose-galactose malabsorption, saharazy- isomaltase deficiency.
– Hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis.
– Pregnancy (III trimester).
– Children up to age 12 years.
Carefully:
In the presence of the conditions referred to in this section should consult a physician before using the product.
Simultaneous treatment with other NSAIDs, a history of a single episode of gastric ulcer or gastrointestinal bleeding ulcer; gastritis, enteritis, colitis, the presence of infection Helicobacter pylori, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or history – possibly bronchoconstriction; systemic lupus erythematosus or mixed connective tissue disease (Sharp’s syndrome) – increased risk of aseptic meningitis; renal failure, including during dehydration (creatinine clearance of less than 30-60 ml / min), nefroticheeky syndrome, liver failure, cirrhosis with portal hypertension, hyperbilirubinemia, hypertension and / or heart failure, cerebrovascular disease, blood disease of unknown etiology ( leukopenia and anemia), severe somatic diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol use, or phenylketonuria Napier Oshima phenylalanine, simultaneous use of drugs that may increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), pregnancy I-II trimester, during breastfeeding, older age.
Dosage
200 mg
Indications
Nurofen® Express Neo is used for headache, toothache, migraine, painful menstruation, neuralgia, back pain, muscular and rheumatic pain; as well as feverish with the flu and colds.
Interaction with other drugs
It should avoid the simultaneous use of ibuprofen with the following drugs:
Acetylsalicylic acid: with the exception of low-dose acetylsalicylic acid (not more than 75 mg per day), prescribed by the doctor, since the combined use may increase the risk of side effects. With simultaneous use of ibuprofen reduces inflammatory and antiplatelet effect of acetylsalicylic acid (may increase the incidence of acute coronary insufficiency in patients receiving as antiplatelet agents acetylsalicylic acid, low dose, after initiation of ibuprofen).
Other NSAIDs, in particular, selective COX-2 inhibitors: avoid simultaneous use of two or more agents from the group of NSAIDs due to possible increased risk of side effects.
Precautions used simultaneously with the following drugs:
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, particularly warfarin and thrombolytic agents.
Antihypertensive agents (ACE inhibitors and angiotensin II) and diuretics NSAIDs may reduce efficacy of these groups. In some patients with impaired renal function (e.g., patients with dehydration or in elderly patients with impaired renal function) co-administration of ACE inhibitors or antagonists of angiotensin II and agents that inhibit cyclooxygenase, may lead to a deterioration of renal function, including the development of acute renal failure (usually reversible). These interactions should be considered in patients taking coxibs simultaneously with ACE inhibitors or angiotensin II. Therefore, the combined use of the above means should be used with caution, especially in the elderly. It is necessary to prevent dehydration in patients, and consider monitoring renal function after initiation of such combination therapy and periodically thereafter. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
Steroids: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Cardiac glycosides: co-administration of NSAIDs and cardiac glycosides can lead to aggravation of heart failure, decreased glomerular filtration rate and an increase in concentration of cardiac glycosides in blood plasma.
of lithium drugs: there is evidence of the likelihood of increasing the concentration of lithium in blood plasma during treatment with NSAIDs.
Methotrexate: there is evidence of the likelihood of increasing concentration of methotrexate in the blood plasma during treatment with NSAIDs.
Cyclosporin: increased risk of nephrotoxicity with concomitant administration of NSAIDs and cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8-12 days after mifepristone administration as NSAIDs can reduce the efficacy of mifepristone.
Tacrolimus: while the appointment of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Zidovudine: simultaneous application of NSAIDs and zidovudine could result in increased gematotoksichnosti. There is evidence of increased risk of haemarthrosis and hematoma in HIV-positive patients with hemophilia who received co-treatment with zidovudine and ibuprofen.
Quinolone antibiotics series: patients receiving collaborative care NSAIDs and quinolone antibiotics series, may increase the risk of seizures.
Mielotoksicskie preparations: increase the expression gematotoksichnosti drug.
Caffeine: enhances the analgesic effect.
Overdose
In children, the symptoms of overdose may occur after ingestion of a dose exceeding 400 mg / kg body weight. In adults, a dose-dependent effect of an overdose is less pronounced. The half-life of the drug overdose is 1.5-3 hours.
Symptoms include nausea, vomiting, epigastric pain, or more rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, there are manifestations of the central nervous system: drowsiness, rarely agitation, convulsions, disorientation, coma. In cases of severe poisoning can develop metabolic acidosis and increased prothrombin time, kidney failure, liver damage tissue, blood pressure, respiratory depression and cyanosis. Patients with asthma may increase the disease.
Treatment: symptomatic, with obligatory airway, ECG monitoring and vital signs up to the normalization condition of the patient. We recommend the use of activated charcoal oral or gastric lavage for 1 hours after administration of potentially toxic doses of ibuprofen. If ibuprofen has already been absorbed, it can be assigned to alkaline water with the aim of removing the acid derivative of ibuprofen kidney diuresis. Frequent or prolonged convulsions should be to stop the intravenous administration of diazepam or lorazepam. When deterioration of asthma recommend the use of bronchodilators.
pharmachologic effect
Pharmacological group:
nonsteroidal anti-inflammatory drug (NSAID)
Pharmacodynamics:
The mechanism of action of ibuprofen, the propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs) is due to the inhibition of prostaglandin synthesis of mediators of pain, inflammation and hyperthermic response. Indiscriminately blocks cyclooxygenase 1
(COX-1) and cyclooxygenase 2 (COX-2), thereby inhibits the synthesis of prostaglandins. It provides quick directional effect against pain (analgesic), antipyretic and anti-inflammatory effect. Furthermore, ibuprofen reversibly inhibits platelet aggregation.
Pharmacokinetics:
High absorption, is rapidly and almost completely absorbed from the gastrointestinal tract (GIT). After receiving two tablets of the drug on an empty stomach ibuprofen found in blood plasma after 15 minutes, the maximum concentration (Cmax) in plasma of ibuprofen is achieved in 30-35 minutes, two times faster than after ingestion of an equivalent dose Nurofen drug in the dosage form of tablets, coated 200 mg. The drug with food can increase the time to reach maximum concentration (TSmax). Communication with plasma proteins than 90%, half-life (T1 / 2) for 2 hours. Slowly into the joint cavity, it is retained in the synovial fluid, making it larger concentration than in blood plasma. After absorption of about 60% pharmacologically inactive R-form is transformed slowly into the active S-shape. It is metabolized in the liver. Excreted by the kidneys (in unmodified form are not more than 1%) and, to a lesser extent in the bile.
Older people have not detected significant differences in the pharmacokinetic profile of the drug as compared to younger people.
In limited studies, ibuprofen was detected in breast milk in very low concentrations.
Pregnancy and breast-feeding
Application of pregnancy and during breastfeeding
Do not use this drug in the III trimester. It should avoid the use of the drug in the I-II trimester of pregnancy should consult a physician if necessary dose.
There is evidence that ibuprofen in small quantities can penetrate into breast milk without any adverse effects on the baby’s health, so it is usually in short-term need for the reception termination of breastfeeding does not arise. If necessary, long-term use of the drug should consult a doctor to decide on the termination of breastfeeding during treatment.
Conditions of supply of pharmacies
Without recipe.
side effects
The risk of side effects can be minimized, if you take a short course of the drug in the lowest effective dose needed to control symptoms.
In the elderly there is an increased frequency of adverse reactions to treatment with NSAIDs, especially gastrointestinal bleeding and perforation, in some cases fatal.
Side effects are mainly dose dependent. In particular, the risk of gastrointestinal bleeding depends on the dosage range and duration of treatment.
The following adverse reactions were observed at short ibuprofen in doses not to exceed 1200 mg / day (6 tablets). In the treatment of chronic conditions and long-term use may cause other adverse reactions.
Qualification frequency of occurrence of adverse reactions performed on the basis of the following criteria: very frequent (> 1/10), frequent (from> 1/100 to
special instructions
It is recommended to take the drug the maximum possible short-course, and in the lowest effective dose needed to control symptoms. In patients with bronchial asthma or allergic disease in the acute phase as well as in patients with a history of asthma / allergy disorders preparation may provoke bronchospasm. Use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease associated with an increased risk of aseptic meningitis.
During long-term treatment is required to monitor patterns of peripheral blood and functional state of the liver and kidneys. When symptoms gastropathy shown careful control, comprising carrying esophagogastroduodenoscopy, total blood (hemoglobin), analysis of fecal occult blood. If necessary, the definition of 17-ketosteroids drug should be discontinued 48 hours prior to the study. During the period of treatment is not recommended intake of ethanol.
Patients with renal failure should consult a physician before using the product, since there is a risk of deterioration of renal function.
Patients with hypertension, including a history of and / or chronic heart failure, it is necessary to consult a physician before using the drug as the drug can cause fluid retention, hypertension and edema.
Information for women planning pregnancy: these drugs inhibit the cyclooxygenase and prostaglandin synthesis, affect ovulation, disrupting the female reproductive function (reversible after discontinuation of treatment).
Effects on ability to transp. Wed. and fur .:
Patients marking dizziness, drowsiness, confusion or visual disturbances while taking ibuprofen, should avoid driving vehicles or machinery control.
Storage conditions
In a dry place at a temperature not higher than 25 ° C.
Keep out of the reach of children
Dosing and Administration
Please read the instructions before taking the drug.
For ingestion. Only for short-term use.
Adults and children over 12 years in, after a meal 1 tablet (200 mg) 3-4 times a day. The tablets should be taken with water. The interval between doses of the drug should be at least 4 hours.
To achieve a rapid therapeutic effect in the adult dose may be increased to two tablets (400 mg) 3 times a day.
Do not take more than 6 tablets in 24 hours.
The maximum daily dose is 1200 mg.
The maximum daily dose for children 12-17 years of age is 1,000 mg.
If you are taking the drug for 2-3 days the symptoms persist or intensify, it is necessary to stop treatment and seek medical advice.
If necessary, the administration of the drug for more than 10 days, you must consult your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Nurofen

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