Fungoterbin cream 1% 15g tube

Description

Composition
Active substance:
Terbinafine hydrochloride (calculated as 100% dry basis) – 1.0 g ;.
Excipients:
Butylated hydroxytoluene (BHT) – 0.1 g of urea (carbamide) – 0.50 g, macrogol tsetostearat (Eumulgin® B 2) – 1.50 g of cetostearyl alcohol [cetyl alcohol not more than 60%, stearyl alcohol of not less than 40% ] (Lanette® O) – 4,70 g, poloxamer (emuksol-268, lutrol F 68) – 0.75 g, imidurea (Germall) – 0,20 g, propylene glycol – 23.00 g, liquid paraffin (vaseline oil medical) – 35,00 g vaseline – 7.00 g of water (purified water) – up to 100 g
Description:
Cream, white or nearly white with a faint odor.
Product form:
Cream for external application of 1%.
15 g aluminum tubes or plastic laminate. Each tube together with instructions for medical use the drug in a stack of cardboard.
Contraindications
Hypersensitivity to terbinafine and / or other components of the formulation.
Dosage
1 %
Indications
Fungal diseases of the skin caused by susceptible pathogens (trihofitia, mikrosporiya, athlete, rubrofitii, candidiasis skin):
athlete’s foot / “foot fungus» (tinea pedis); mycosis body (tinea corporis), including mycosis fungoides skin smooth and large folds; inguinal tinea (tinea craris), superficial skin candidiasis caused by fungi of the genus Candida (e.g., Candida albicans); pityriasis versicolor (pityriasis versicolor).
Interaction with other drugs
Any interaction Fungoterbin® cream with other drugs are not known.
Overdose
When applied topically unlikely.
Symptoms: Accidental admission cream into possible headache, nausea, gastralgia, dizziness, frequent urination, rash.
Treatment: activated charcoal, if necessary – symptomatic and supportive therapy.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Antifungal agent for topical application, is the allylamine and has a broad spectrum of antifungal activity. Characterized by severe epidermotropnostyu. Target for terbinafine is cytoplasmic membrane of fungal cells.
Terbinafine acts on the early stages of sterol metabolism on skvalenepoksidaznogo cycle level. Suppressing enzyme squalene, terbinafine inhibits the formation of ergosterol – primary cell wall component of fungi, preventing them from further reproduction. Squalene is not associated with the P450 system.
Fungicidal effect is caused by the accumulation of squalene in the fungal cell, which is extracted from the lipid components of membranes. Accumulating intracellularly lipid granules, gradually increasing in volume, tear defective cytoplasmic membrane, resulting in fungal cell death.
Terbinafine is highly active against all dermatophyte, Trichophyton united in labor, Microsporum and Epidermophyton.
Terbinafine in small concentrations has a fungicidal effect against dermatophytes (Trichophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum; Microsporum canis and Epidermophyton floccosum); mold (Aspergillus spp, Scopulariopsis brevicaulis.), yeast – Candida albicans, C. stellatoidea, C. tropicalis, C. parapsilosis, C. guillermondi, C. kursei, C. pseudotropicalis, Pityrosporum orbiculare (P. ovale and Malassezia furfur); dimorphic fungi (Sporothrix schenckii, etc.).
Terbinafine effect against yeasts, depending on their type, may be a fungicide (Candida parapsilosis) or fungistatic (Candida albicans). Fungoterbin® also has anti-inflammatory, antipruritic, keratolytic action. Due to the presence of urea in a cream, the drug has a moisturizing effect, it promotes deeper penetration into the skin of terbinafine.
Pharmacokinetics:
When applied topically the drug is absorbed only slightly (absorption – 5%); accumulates in the skin, sebaceous glands, hair follicles, subcutaneous tissue and exert its action mostly at the site of application.
Pregnancy and breast-feeding
It is possible only after a careful assessment of the expected benefits to the mother and the risk to the fetus. If necessary, use fungoterbin® cream during lactation is necessary to avoid contact with the baby treated fungoterbinom® area. Not recommended for use on large surfaces.
Conditions of supply of pharmacies
Without recipe.
side effects
Local reactions: itching and burning of the skin, flushing (redness) at the site of application. Discontinuation of treatment do not require.
Allergic reactions: generalized rash, urticaria, angioedema. Treatment should be discontinued and seek medical advice.
special instructions
Avoid contact with the mucous membrane of eyes, nose, mouth. In case of contact with running water should be washed immediately in the eye.
Restoring healthy appearance of the skin is marked in the first few days of treatment, it is not a sign of healing. It should be remembered that the use of irregular or premature discontinuation of treatment increases the risk of relapse.
The treatment must comply with the general rules of hygiene for the prevention of reinfection (reinfection) through underwear and shoes. No effect after 1 week of treatment requires diagnosis.
Fungoterbin® does not violate the functions of the skin and work its sebaceous and sweat glands.
Fungoterbin® has a subtle scent and leaves no residue on clothes.
Effects on ability to drive vehicles and management mechanisms
Does not affect.
Storage conditions
Store at a temperature of from 10 to 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly.
Before use, clean and dry the affected area. Fungoterbin applied 1 or 2 times per day to the affected areas of skin and adjacent area. The cream is applied with a thin layer and gently rubbed. When applied to the area of ​​skin folds (inguinal region, mezhyagodichnoy, under the breasts) is recommended to install a gauze strip / bandage.
Ringworm of the body, large folds, feet, legs: 1 time per day, duration of treatment – 1 week.
Tinea pedis: 1 time per day, duration of treatment – 1 week.
Skin candidiasis: 1 – 2 times per day, duration of treatment – 1 – 2 weeks.
Pityriasis versicolor: 1 – 2 times per day, duration of treatment – 1 week.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist