Bronhobos syrup 5% 200ml fl

Description

Composition
Active substance:
5 ml syrup 2.5% (1 measuring spoon) contain: carbocisteine ​​125.00 mg. 5 ml syrup 5% (1 measuring spoon) contain: carbocisteine ​​250.00 mg.
Excipients:
Glycerol 135.00 mg ethanol 96% 125.00 mg Sodium hydroxide 30.5 mg (61.00 mg), sodium carmellose 20.00 mg Citric Acid Monohydrate 5.00 mg (10.00 mg), methyl parahydroxybenzoate 9 , 00 mg, 5.00 mg sodium saccharinate, propyl parahydroxybenzoate 1.00 mg, 0.70 mg raspberry flavor, azorubin CI 14720 (E 122) 0.05 mg purified water to 5.00 ml.
Description:
Transparent slightly viscous liquid with a smell of raspberries, from pink to red.
Product form:
Syrup 2.5% (125 mg / 5 ml) and 5% (250 mg / 5 mL). 200 ml brown glass vial, a sealed aluminum lid with tamper-evident or a screw cap fitted with a child lock mechanism and the seal of the first control opening. 1 bottle with instructions for use and scoop with the applied labels, and 5 ml of 2.5 ml were placed in a cardboard box.
Contraindications
– Liver disease – Alcohol – Epilepsy, – injury or brain disease, – increased sensitivity to the drug or to auxiliary components belonging to it, – Gastric ulcer and duodenum 12 in the acute stage, – Chronic glomerulonephritis (exacerbation ) – Cystitis – children under the age of 3 years (for syrup 2.5%), children up to 15 years (the syrup 5%).
Carefully
Peptic ulcer and 12 duodenal ulcer (in history).
Dosage
50 mg / ml
Indications
Acute and chronic bronchopulmonary diseases associated with impaired mucus formation and excretion (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis); inflammatory diseases of the middle ear and sinuses (rhinitis, otitis media, sinusitis); Preparing the patient for bronchoscopy or bronhografii.
Interaction with other drugs
Enhances effectiveness of glucocorticoid (mutually) and antibiotic therapy of infectious and inflammatory diseases of the upper and lower respiratory tract. Potentiate the bronchodilator effect of theophylline. antitussive activity carbocisteine ​​weaken and atropine means. Because of the alcohol content Bronhobos® prescribed with caution with the following drugs: Drugs causing adverse reactions (fever, redness, vomiting, tachycardia), while taking with alcohol: disulfiram, cefamandole, ceftazidime, latamoxef (cephalosporin antibiotics), chloramphenicol (fenikolovy antibiotic) chlorpropamide, glibenclamide, glipizide, tolbutamide (antidiabetic sulfa drugs), griseofulvin (antifungal agent), 5-nitro-imidazoles (metronidazole, ornidazole, secnidazole, tinida angry), ketoconazole, procarbazine (cytostatic). Drugs depressing the central nervous system.
Overdose
Symptoms: stomach pain, nausea, diarrhea.
Treatment: symptomatic.
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent.
Pharmacodynamics:
Mucolytic and expectorant action is caused by activation of sialic transferase – enzyme goblet cells of the bronchial mucosa. Normalizes the proportion of acidic and neutral sialomutsinov bronchial secretions, recovers viscosity and elasticity of the mucus. Promotes regeneration of the mucosa, normalizes its structure, activates the activity of the ciliary epithelium. Restores the secretion of immunologically active IgA (specific protection) and the number of sulfhydryl groups mucus components (non-specific protection), improves mucociliary clearance.
Pharmacokinetics:
Absorption – rapid and nearly complete. Bioavailability – low (less than 10% of the dose). The time to reach maximum concentration in the blood and in the mucosa – 1.5-2 hours, a therapeutic concentration is maintained in the blood for 8 hours longest retained in the blood, liver and middle ear.. At high concentrations accumulate in bronchial secretions (17.5% of the dose). It is metabolized in the liver (which has the effect of “first pass” through the liver). Excreted by the kidneys (60-90% unchanged, the rest – in the form of metabolites). The half -. 2-3,15 h Total excretion occurs after 3 days.
Pregnancy and breast-feeding
Application Bronhobos® the drug during pregnancy and lactation is contraindicated.
Conditions of supply of pharmacies
Without recipe.
side effects
On the part of the gastrointestinal tract:
Sometimes there is nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.
Hypersensitivity Reactions:
It is noted isolated cases allergic reactions (pruritus, rash, rash, angioedema).
Other: dizziness, weakness, malaise.
In patients with asthma and elderly patients may cause airway obstruction.
special instructions
The alcohol content in the formulation is 125 mg / 5 ml, i.e. 125 mg of alcohol per scoop.
Effects on ability to transport and work on the machines
Violation of the speed of psychomotor reactions associated with the presence of alcohol in the product may be dangerous when driving a car or working on the machines.
Storage conditions
At a temperature of not higher than 30 C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
Inside.
For dosing the syrup used measuring spoon of 5 ml, 2.5 ml graded. 1 measuring spoon of syrup 5% (5 ml) = 250 mg carbocisteine. 1 measuring spoon of syrup 2.5% (5 ml) = 125 mg carbocisteine.
Adults: 15 ml (3 scoops) 5% syrup three times a day.
Children aged 3-6 years – 5 ml (1 measuring spoon) 2.5% syrup 2-4 times per day.
Children over 6 years of age – 10.5 ml (1-2 spoons dimensional) 2.5% syrup 3 times a day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist