Aziks-Derm cream 20% 30g tube

Description

Composition
Active substance:
In 1 g of cream contains: 200 mg azelaic acid.
Excipients:
Benzoic acid, arlaton 983 (glyceryl monostearate), cutin CBS, krodamol ATS, silicone oil 350 CST, propylene glycol, glycerol, purified water.
Description:
White, opaque, homogeneous cream.
Product form:
Cream for external use of 20%. 30 g of cream into a tube of aluminum foil laminated with coated screw cap; 1 tube with instructions for use in a cardboard box.
Contraindications
Increased sensitivity to the drug. Children up to age 12 years.
Dosage
20 %
Indications
Acne vulgaris (acne vulgaris). Pathological hyperpigmentation, including melasma.
Interaction with other drugs
The interaction of the drug-Derm Aziks with other drugs hitherto not known.
Overdose
At present, cases of overdose Aziks cream-Derm is not described.
pharmachologic effect
Pharmacological group:
A treatment for acne.
Pharmacodynamics:
It causes mild cytotoxic effect (by inhibiting the synthesis of cell proteins), which manifests itself in normalization of keratinization processes in the wall of follicular sebaceous glands; It has antimicrobial activity (primarily against Propionibacterium acnes and Staphylococcus epidermidis) both on the skin surface and sebaceous glands, as well as anti-inflammatory effects (reducing metabolism of neutrophilic granulocytes and production of free radical forms of oxygen – the important factors in maintaining the inflammatory process). With long-term use of the drug is not formed microbial resistance.
Azelaic acid dose-dependently inhibited the growth and survival of abnormal melanocytes. The therapeutic effect in hyperpigmentation (melasma) due to inhibition of DNA synthesis and / or inhibition of cell respiration abnormal melanocytes.
The therapeutic effect of azelaic acid with rosacea associated with a decreased formation of inflammatory reactive oxygen radicals.
Pharmacokinetics:
Suction. After application to the skin cream Aziks-Derm azelaic acid penetrates into the epidermis and dermis. After application to the skin 1 g of azelaic acid (corresponding to 5 g of a cream), about 4% of the dose is absorbed into the systemic circulation. Withdrawal. Part sucked azelaic acid excreted by the kidneys in unchanged form, and the part in the form of dicarboxylic acids (C5, C7), formed of azelaic acid by beta-oxidation.
Pregnancy and breast-feeding
During pregnancy and lactation period, the drug is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child. You should avoid applying the cream on the area of ​​the breast before feeding.
Conditions of supply of pharmacies
Without recipe.
side effects
For the skin. Rarely (mainly at the beginning of therapy): irritation of the skin, skin flushing, erythema, burning sensation, itching, peeling, which are themselves in the course of further treatment. May cause allergic reactions (e.g., rashes). After application of the cream on the skin may feel burning and stinging, which extends for 15 min.
special instructions
Avoid exposure of drug in the eye, and mucous membranes of the nose, lips and mouth. If this occurs, immediately rinse them with plenty of water. In cases of strong expression of skin irritation during the first week of treatment Aziks-Derm can be applied 1 time / day or reduce the amount of cream applied to the skin; also possible short-term removal of the drug. After the disappearance of the symptoms of skin irritation should resume regular use of the drug at the recommended dose.
Dermal melasma is not sensitive to drug treatment. For differential diagnosis use lamp Wood. Aziks-Derm be used in combination with other methods of treatment of acne. Thus a correction may be applied simultaneously dosing regimens of drugs.
Management of vehicles and mechanisms: Aziks-Derm has no effect on the reaction rate when driving or operating other machines.
Storage conditions
Store at a temperature not higher than 25 ° C. Do not freeze. Keep out of the reach of children.
Dosing and Administration
Outwardly.
The maximum duration of treatment depends on the individual picture of the disease and the severity of symptoms, and is set by the attending physician.
Adults and children over 12 years of cream is applied uniformly with a thin layer 2 times / day (morning and evening) on ​​the precleaned (mild detergent and water) and dried parts of the face skin and, if necessary, neck and upper chest, affected by acne.
For all the face surface enough about 2.5 cm column of cream from the tube. The drug should be used regularly throughout the course of treatment, the duration of which depends on the severity of the disease. The minimum treatment duration is 3 months melasma. In treatment of melasma should necessarily apply sunscreens (UV B and UV A) to prevent exacerbation of the disease and / or re-pigmentation of the skin under the influence of the sun. In patients with acne ordinary (acne vulgaris) marked improvement is usually seen after 4 weeks. For best results, use of the drug should continue for several months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist