Aktiferrin syrup 100ml vials

Description

Composition
Active substance:
1 ml contains: 47.2 mg of iron sulfate (corresponding to 9.48 mg of ferrous iron), D, L-serine 35.6 mg.
Excipients:
Potassium sorbate; vitamin C; sugar invert syrup; of 94% ethanol; Raspberry flavoring; a creamy flavor; purified water.
Description:
The transparent, greenish to yellowish-brownish liquid with raspberry cream flavor.
Product form:
Syrup, a bottle of dark glass.
100 ml bottle.
Contraindications
Hypersensitivity to the drug; iron overload (hemosiderosis, hemochromatosis); other types of anemia is not caused by an iron deficiency in an organism; sideroahrestical anemia, anemia in lead poisoning, thalassemia, hemolytic and aplastic anemia; Late skin porphyria; chronic hemolysis.
Precautions: patients with gastric ulcer and duodenal ulcer, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn’s disease), alcohol (active or in remission), allergic diseases, bronchial asthma, hepatitis, hepatic or renal failure, rheumatoid arthritis, blood transfusion.
Care must be taken when assigning drops diabetics – 18 drops (1 ml) contains 64 mg of glucose, equivalent to 0.15 XE and XE 0.0053 respectively.
Indications
Iron deficiency anemia of various etiology; latent iron deficiency associated with excessive losses of iron (bleeding, including uterine, permanent donation) or an increased need for it (pregnancy, lactation, the period of active growth, menopause, malnutrition, chronic gastritis with secretory insufficiency condition after resection of the stomach, gastric ulcer and duodenal ulcers, decrease the body’s resistance to adults and children with infectious diseases, tumors).
Interaction with other drugs
Deferoxamine – specific antidote. Antacids, calcium preparations, etidronic acid, drugs that reduce gastric acidity (including cimetidine, formulations containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, milk, vegetables, cereals, egg yolk, tea, coffee reduce the absorption of the drug (the interval between doses should be 1-2 hours). Ascorbic acid enhances the absorption. Reduces absorption fluoroquinolones, penicillamine, tetracyclines (interval between reception should also be 2 hours).
Large doses of iron preparations reduce renal zinc absorption drugs (interval between doses should be 2 hours). Ethanol increases the absorption of iron and the risk of toxic complications.
Reduce the absorption of black tea, coffee, milk and solid food, bread, raw cereals, dairy products, eggs.
Overdose
Symptoms: weakness, fatigue, paresthesia, pallor, cold clammy sweat, lowering blood pressure, palpitations, akrozianoz, abdominal pain, diarrhea mixed with blood, vomiting, cyanosis, confusion, weak pulse, pyrexia, lethargy, seizures, symptoms hyperventilation, coma.
Signs of peripheral circulatory collapse occur within 30 minutes after administration; metabolic acidosis, seizures, fever, leukocytosis, coma – for 12-24 hours; acute renal and hepatic necrosis – 2-4 days.
Treatment: before specific therapy – take steps to remove the drug has not grown deep (gastric lavage), give milk, raw eggs. Specific therapy – oral and parenteral deferoxamine. In acute poisoning to bind more nevsosavsheysya iron from the digestive tract, are inside 5-10 g product dissolving 10 -20 vials in drinking water.
With the development of phenomena of poisoning administered deferoxamine / m slowly children – 15 mg / hr, adults – 5 mg / kg / h (80 mg / kg / day); under mild poisoning: V / m, the children – 1 g every 4-6 hours, adults – 50 mg / kg (up to 4 g / day); in severe poisoning, accompanied by shock / drip is administered 1 g of the preparation and symptomatic therapy.
Hemodialysis is ineffective for removal of iron, but can be used to accelerate the elimination deferoksaminovogo-iron complex, and can also be administered at oligo- and anuria. Perhaps a peritoneal dialysis.
pharmachologic effect
Pharmacological group:
iron preparations in combination with other drugs.
Pharmacological properties:
Hematopoietic, iron preparation.
Pharmacodynamics:
Hematopoietic effect. The complex compound of iron sulfate (II) and serine promotes iron resorption and quickly restores its normal content in the body, contributing to the progressive clinical regression (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory signs of anemia. Good absorption of iron can reduce the dose and ensure good tolerability. Quickly replenishes iron deficiency in the body.
Pharmacokinetics:
After oral administration of the drug included iron sufficiently fully absorbed from the gastrointestinal tract into the systemic circulation. There is a correlation between the degree of iron deficiency and the amount of iron absorbed into the systemic circulation (the higher iron deficiency, the better absorption).
Tmax is reached during the first 2-4 hours after ingestion.
Excreted in the urine, feces, sweat.
Pregnancy and breast-feeding
When established iron deficiency in the body to use the drug during pregnancy and breastfeeding is considered reasonable and safe.
Conditions of supply of pharmacies
On prescription.
side effects
On the part of the digestive tract: loss of appetite, bitter taste in the mouth, bloating, constipation, diarrhea, rarely – abdominal pain, nausea, vomiting.
Allergic reactions: itching, rash, rarely – anafilatichesky shock.
Other symptoms include headache, dizziness, flushing of the skin, toothache, sore throat, weakness, feeling of pressure in the chest, irritability; rare – with epileptic encephalopathy syndrome.
special instructions
In exchange the appointment of the drug requires regular monitoring of hemoglobin.
To prevent the appearance on the teeth of patients reversible black deposit Aktiferrin Syrup should not be taken undiluted, and after receiving the recommended brush your teeth thoroughly.
Notes staining stool black.
To open the bottle you should press the cap down and turn in the direction of the arrow at the same time. After application of the cap and tightly screw the set (prevents access to children).
Storage conditions
Store at a temperature not higher than 25 C.
Dosing and Administration
Inside, just before a meal or during meal time, drinking water or fruit tea.
Children over 2 years of age – a daily dose of 5 ml per 12 kg of body weight. The average dose is: pre-school children – 5 ml 1-2 times a day, school-age children – 5 ml 2-3 times a day.
After reaching normal values ​​of serum iron and hemoglobin maintenance dose treatment is continued for at least 8-12 weeks.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist