Vikasol tab 15mg 20 pc

Description

Composition
Active substance:
1 tablet contains: menadione sodium bisulfite (menadione) (relative to anhydrous substance) – 15 mg.
Product form:
15 mg Tablets
Packing 20 tablets.
Contraindications
Hypersensitivity, hypercoagulation, thrombosis, deficit sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption, Hemolytic disease of the newborn, children up to 3 years.
Carefully.
Deficiency of glucose-6-phosphate dehydrogenase, liver failure.
Dosage
15 mg
Indications
Hemorrhagic syndrome associated with gipoprotrombinemiey; hypovitaminosis K (including the obstructive jaundice, hepatitis, cirrhosis, prolonged diarrhea); bleeding after injuries, injuries and surgical interventions; in the complex therapy of dysfunctional uterine bleeding, menorrhagia. Overdose preparations of vitamin K-antagonists (etilbiskumatsetata, phenindione and m. P.).
Interaction with other drugs
It reduces or blocks the anticoagulant effect of indirect anticoagulants – etilbiskumatsetata and phenindione. It does not affect the anticoagulant activity of heparin. Antacids reduce the absorption due to precipitation of salts of bile acids in the initial section of the small intestine. The simultaneous use of broad-spectrum antibiotics, quinidine, quinine, salicylates in high doses, sulfonamides require increased doses of vitamin C. Cholestyramine, colestipol, mineral oil, sucralfate, dactinomycin reduce the absorption of vitamin K, which requires increasing the dose. The simultaneous use of drugs that cause hemolysis, increases the risk of side effects.
Overdose
Symptoms: In case of overdose occur hypervitaminosis K manifested giperprotrombinemiey, hyperbilirubinemia, rarely, children may have seizures.
Treatment: symptomatic.
pharmachologic effect
Pharmacological group:
Vitamins.
Pharmacodynamics:
Synthetic water-soluble analogue of vitamin K, promotes the synthesis of prothrombin and proconvertin, increases blood coagulation by enhancing the synthesis of II, VII, IX, X blood coagulation factors. Has hemostatic action (when vitamin K deficiency arises increased bleeding). In the blood, prothrombin (factor II) in the presence of thromboplastin and calcium ions, the participation proconvertin (VII factor), blood clotting factors IX (Kristmass factor), X (factor Stewart-Prauera) passes into thrombin, under the influence of which the fibrinogen is converted to fibrin forming the basis of a blood clot (thrombus). Substrate stimulates vitamin K-epoksidreduktazu activating vitamin K and ensures its participation in the hepatic synthesis of K-vitaminozavisimyh plasma hemostasis factors.
Pharmacokinetics:
After oral administration, easily and quickly absorbed. In small amounts accumulate in the tissues. Rapidly passing cycle metabolic activation in the liver diol is oxidized to form. Excreted by the kidneys and the bile almost exclusively as metabolites. High concentrations of vitamin K in the feces due to its synthesis intestinal microflora.
Pregnancy and breast-feeding
It is used strictly on the evidence in the last months of pregnancy (to eliminate bleeding in the mother) under the supervision of a physician.
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions: facial flushing, skin rash (including erythematous, urticaria), itching of the skin, bronchospasm.
Blood system: hemolytic anemia, hemolysis in newborns with congenital deficiency of glucose-6-dehydrogenase.
Other: hyperbilirubinemia, jaundice (including kernicterus in infants), dizziness, a transient decrease in blood pressure, profuse sweating, tachycardia, “weak” filling rate, change in taste.
special instructions
In diseases that lead to disruption of bile flow, it is recommended to use the other dosage form – solution for injection. Hemophilia and vWD use of the drug is not effective. The drug does not normalize the function of abnormal platelets. Prophylactic administration of vitamin K in the III trimester inefficient due to low permeability for him placenta.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Dosing and Administration
Inside. Appointed within 3 – 4 days, after four days break, again 3 – 4 days.
The daily dose can be divided into 2 – 3 doses. When the possible surgical interventions bleeding parenchymal strong prescribed for 2 – 3 days before surgery.
The maximum single dose for adults is 15 – 30 mg, with a maximum daily dose for adults – 60 mg.
In pediatrics: 3 – 4 years – 8 mg / day, 5 – 9 years – 10 mg / day, 10 – 14 years – 15 mg / day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist