Advantan emulsion appearance. 0.1% 20g tuba

Description

Composition
Active substance:
1 g of emulsion contain: methylprednisolone aceponate 1 mg.
Excipients:
Medium chain triglycerides, softizan 378, polyoxyethylene-2-stearyl alcohol, 85% glycerol, benzyl alcohol, edetate disodium, purified water.
Description:
White opaque emulsion.
Product form:
5 g, 20 g and 50 g of a laminated aluminum tube, sealed with plastic screw caps. The tube together with instructions for use placed in a cardboard box.
Contraindications
Tuberculous or syphilitic processes in the field of application of the drug. Viral diseases (e.g., chicken pox, herpes zoster) in the coating formulation, rosacea, perioral dermatitis in applying the product. Skin reactions to vaccination in the field of application of the drug. Hypersensitivity to the drug.
Dosage
1 mg / g
Indications
Acute inflammatory skin disease in adults and children from the age of 4 months: atopic dermatitis, atopic dermatitis, contact dermatitis, true eczema, seborrheic eczema, microbial eczema, eczema disgidroticheskaya, degenerative eczema. Solar dermatitis (severe sunburn).
Overdose
The study of acute toxicity methylprednisolone aceponate not revealed any risk of acute toxicity at a single cutaneous excessive use (applying the preparation on a large area under conditions favorable for absorption) or Accidental ingestion.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use.
Pharmacological properties:
The active drug component Advantan – methylprednisolone aceponate – represents a non-halogenated synthetic steroid.
Pharmacodynamics:
When applied topically Advantan suppresses inflammatory and allergic skin reactions as well as reactions associated with enhanced proliferation, which leads to a decrease in objective symptoms (erythema, edema, oozing) and subjective sensations (itching, irritation, pain).
Methylprednisolone aceponate When applied topically in an effective dosage, minimal systemic effect in both humans and animals. After repeated deposition Advantan large surfaces (40 – 60% of the surface of the skin), and the application under an occlusive dressing is not marked disorders of adrenal function: cortisol plasma level and its circadian rhythm remain within the normal range, reducing cortisol level in daily urine occurs.
Methylprednisolone aceponate (particularly its major metabolite – 6-alpha-methylprednisolone 17-propionate) binds to the intracellular glucocorticoid receptor. The steroid-receptor complex binds to specific DNA sites, thus causing a series of biological effects.
In particular, binding of the steroid-receptor complex to DNA results in the induction of synthesis macrocortin. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of inflammatory mediators type prostaglandins and leukotrienes. Inhibition of glucocorticoid synthesis of prostaglandins vasodilating and vasoconstrictive effect of epinephrine potentiation lead to vasoconstrictor effect.
Pharmacokinetics:
Methylprednisolone aceponate is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6-alpha-methylprednisolone 17-propionate, having a much higher affinity for the skin corticoid receptors, indicating that its presence “bioactivation” of the skin. The intensity of absorption through the skin with artificial inflammation was very low (0.27% dose), and was slightly higher than in healthy skin (0.17%). Absorption through the skin with the stratum corneum removed was significantly higher (15%) of the dose. In the case of treatment of the whole body (such as sunburn) systemic dose is about 4 mg per 1 kg of body weight per day, which excludes systemic effects.
After entering the systemic circulation 6-alpha-methylprednisolone 17-propionate rapidly conjugated with glucuronic acid and thus inactivated.
Metabolites methylprednisolone aceponate (chief among which is 6-alpha-methylprednisolone 17-propionate-21-glucuronide) are eliminated primarily by the kidneys with a half-life of about 16 hours. Metilperdnizolona atseponat and its metabolites are not cumulated in the body.
Pregnancy and breast-feeding
If necessary, use Advantan during pregnancy and lactation should carefully weigh the potential risks and expected benefits of treatment. These periods are not recommended for prolonged use of the drug on extensive skin surfaces. In nursing mothers medication should not be applied to the breasts.
Conditions of supply of pharmacies
Without recipe.
side effects
Usually the drug is well tolerated. Sometimes Advantan emulsion may cause local symptoms such as itching, burning, erythema, skin dryness, peeling or bubble formation. As with topical glucocorticosteroids other in rare cases may occur folliculitis and allergic reactions.
special instructions
In the presence of bacterial dermatoses and / or in addition to dermatomycosis Advantanom therapy is necessary to carry out a specific antibacterial or antimycotic treatment.
Avoid getting product in eyes.
After repeated deposition nor in children or in adults Advantan large surfaces (40 – 60% of the skin surface), as well as the application under an occlusive dressing is not marked disorders of adrenal function. However, Advantan emulsion should not be used under occlusive dressing. It should be understood that the diapers (diapers) can create an occlusive effect. As in the case of systemic corticosteroids, glaucoma can develop after administration of topical corticosteroids (e.g., after large doses, or very long-term application, use of occlusive dressings, or application to the skin around the eyes).
Effects on ability to drive and use mechanisms: No effect.
Storage conditions
At temperatures above 25 ° C. Keep out of reach of children.
Dosing and Administration
The drug is applied 1 time per day (for the treatment of sunburn 1, a maximum of 2 times a day) with a thin layer on the affected area, gently rubbing. Usually, treatment should not exceed 2 weeks.
If the skin overly dry when used Advantan emulsion must go to a formulation with a higher fat content (Advantan ointment or fatty ointment Advantan).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist