Triderm cream for external use 15 g

Description

Composition
Active substance:
100 g of cream contains: betamethasone dipropionate – 0.643 mg (equivalent to Betamethasone 0.5 mg), clotrimazole – 10 mg, gentamicin sulfate – equivalent to 1.0 mg (1000
IU) of gentamicin base ;.
Excipients:
Petrolatum – 150 mg propylene glycol – 100 mg, cetostearyl alcohol – 72 mg Liquid paraffin – 60 mg, macrogol tsetostearat – 22.5 mg, benzyl alcohol – 10 mg sodium dihydrogen phosphate dihydrate – 2,995 mg, phosphoric acid – 0.03 mg , phosphoric acid or sodium hydroxide to adjust the pH, purified water qs and 1.0 g
Description:
Uniform soft consistency cream white or almost white, free of visible particles.
Product form:
Cream for external use 0.05% + 0.1% + 1%. 15 g or 30 g of the cream in aluminum tubes, covered and sealed with epoxy lacquer membrane and a plastic screw cap. According to one tube together with instructions for use in a cardboard package.
Contraindications
Hypersensitivity to any of the formulation components, lupus, skin manifestations of syphilis, chickenpox, herpes simplex, post-vaccination reactions skin, children (under 2 years old).
Carefully.
Pregnancy (especially in I trimester), children (> 2 years), long-term treatment, the use of large areas of the skin, or in violation of skin integrity, the use of occlusive dressings (especially in children).
Dosage
0.005 mg + 0,1 mg + 0.01 mg / g
Indications
Dermatoses complicated by infections caused by sensitive pathogens, or suspected to such infections, including – a simple and allergic dermatitis, atopic dermatitis (including atopic dermatitis..) Bounded atopic dermatitis, eczema, dermatomycosis (tinea, candidiasis, pityriasis versicolor) especially in the localization in the groin folds of the skin and large, simple chronic zoster (restricted neurodermatitis).
Interaction with other drugs
Any drug interactions Triderm cream with other drugs have been reported.
Overdose
Symptoms: long-term use of local corticosteroids in high doses may suppress adrenal function with the development of secondary adrenal insufficiency and Cushing’s symptoms, including Cushing’s syndrome.
Overdosing clotrimazole topically applying it does not lead to the appearance of any symptoms.
When a single overdose of gentamicin showing any symptoms and is not expected.
Prolonged treatment with gentamycin at high doses can lead to growth insensitive flora.
Treatment: symptomatic. Acute symptoms of Cushing’s usually reversible. If necessary, a correction of electrolyte imbalance. In the case of chronic
GCS toxicity recommended phasing out of GCS.
pharmachologic effect
Pharmacological group:
Anti-inflammatory, antibacterial, anti-fungal agent.
Pharmacological properties:
Combined preparation for external application.
Cream Triderm combines the anti-inflammatory, antipruritic, anti-allergic and anti-exudative effect of betamethasone dipropionate with clotrimazole antifungal activity and a broad antibacterial activity of gentamicin sulfate.
Clotrimazole has antifungal effect by disrupting the synthesis of ergosterol, which is part of the cell membrane of fungi. It is active against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum,
Microsporum canis, Candida albicans, Pityrosporum orbiculare (Malassezia furtur).
Gentamicin is a broad-spectrum antibiotic of the aminoglycoside. Bactericidal and provides highly effective topical treatment of primary and secondary bacterial infections of skin. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae; gramopolozhitelnyh bacteria: Staphylococcus aureus (coagulase-positive and coagulase-negative some strains producing penicillinase).
Pregnancy and breast-feeding
Application Triderm during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.
Pregnant women should not use the drug to large areas of skin or over a long period of time. It is not known whether the components of the drug are excreted in breast milk. Therefore, the appointment of Triderm during lactation should decide the issue of termination of breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Very rarely observed in the application of Triderm: burning sensation, erythema, exudation, pigmentation disorders and itch.
Side reactions occurring under the application of local glucocorticosteroids (especially when using occlusive dressings): burning sensation, itching, dryness, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae , sudamen.
Adverse reactions due clotrimazole: erythema, tingling, blistering, peeling, local swelling, pruritus, urticaria, skin irritation.
Adverse reactions caused by gentamicin: transient skin irritation (erythema, itching) usually does not require discontinuation of treatment.
special instructions
Cream Triderm is not intended for use in ophthalmology.
Prolonged use of topical antibiotics may occasionally lead to an increase in resistant microorganisms. In this case, as well as stimulation of the development of sensitization or superinfection during treatment cream Triderm, treatment should be discontinued and appropriate therapy appoint. Observed cross allergic reaction with aminoglycoside antibiotics. Any side effects that occur with systemic corticosteroids, including inhibition of adrenocortical function, and may occur when topically applied corticosteroids, especially in children.
Systemic absorption of corticosteroids or gentamicin local application will be higher if the treatment is carried out on large areas of the skin or use of occlusive dressings, especially with prolonged treatment or abuse of skin integrity. It is necessary to avoid the application of gentamicin to open wounds and damaged skin. Otherwise, it may cause side effects typical of gentamicin when administered systemically. These safety precautions in such cases, especially when treating children.
With long-term use of the drug is recommended its abolition gradually.
Pediatric use.
Children drug is prescribed only under strict indications and under medical supervision, as systemic side effects associated with the use of topical corticosteroids, they may develop more frequently than in adults. These side effects include suppression of the hypothalamic-pituitary-adrenal axis; Cushing’s syndrome; growth retardation; slowing of weight gain; It increased intracranial pressure, which manifests itself bulging fontanelle, headache, bilateral papilledema.
Effects on ability to drive and use machines.
It does not reveal any influence Triderm drug on the ability to drive and use machines.
Storage conditions
At temperatures above 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly.
Apply a thin layer to the entire surface of the affected skin and surrounding tissue twice a day – morning and night. To ensure the effectiveness of the treatment Triderm cream should be applied regularly. The duration of treatment depends on the size and location of the lesion and the patient’s response.
If clinical improvement does not occur after 3-4 weeks of treatment, it can serve as a pretext for further diagnosis.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist