Vilprafen tab n / 500mg film about 10 pc


Vilprafen tab n / 500mg film about 10 pc

4 in stock



Active substance:
1 coated tablet contains 500 mg of josamycin.
Microcrystalline cellulose, polysorbate 80, precipitated silica, sodium carboxymethylcellulose, magnesium stearate, methyl cellulose, polyethylene glycol 6000, talc, titanium dioxide, aluminum hydroxide, a copolymer of methacrylic acid and its esters.
Tablets white or nearly white, oblong, biconvex, with risks on both sides.
Product form:
Tablets of 500 mg. 10 film-coated tablets in the blister pack 1 into blister cardboard pack.
Hypersensitivity to macrolide antibiotics severe hepatic dysfunction.
500 mg
Acute and chronic infections caused by susceptible to malaria infections, such as:
Upper respiratory tract infection and upper respiratory tract:
Tonsillitis, pharyngitis, paratonzillit, laryngitis, otitis media, sinusitis, diphtheria (further treatment diphtheria toxoid), and scarlet fever in the case of hypersensitivity to penicillin.
Lower respiratory tract infections:
Acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia (including caused by atypical pathogens), whooping cough, psittacosis.
dental infections
Gingivitis and periodontal disease.
Infections in oftalmalogii
Blepharitis, dacryocystitis.
Infections of skin and soft tissue
Pyoderma, furunculosis, anthrax, erysipelas (hypersensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum.
Infections of the genitourinary system
Prostatitis, urethritis, gonorrhea, syphilis (hypersensitivity to penicillin), chlamydial, mycoplasmal (including ureaplasmal) and mixed infections.
Interaction with other drugs
Vilprafen Soljutab / other antibiotics
Since bacteriostatic antibiotics can reduce the bactericidal effect of other antibiotics such as penicillins and cephalosporins, josamycin joint appointment should be avoided with these types of antibiotics. Josamycin should not be administered in conjunction with lincomycin as possible a mutual reduction of their effectiveness.
Vilprafen Soljutab / xanthine
Some representatives of macrolide antibiotics slow the elimination of xanthines (theophylline), which could lead to possible intoxication. Clinical and experimental studies indicate that josamycin has less effect on the allocation of theophylline than other macrolides antibiotics.
Vilprafen Soljutab / antihistamines
After concomitant administration of antihistamines and josamycin containing terfenadine or astemizole, there may be a slowing excretion of terfenadine and astemizole, in turn, can lead to life-threatening cardiac arrhythmias.
Vilprafen Soljutab / ergot alkaloids
There are individual reports on the strengthening of vasoconstriction after concomitant administration of ergot alkaloids and macrolide antibiotics. It noted one case of absence of the patient’s intolerance when taking ergotamine josamycin. Therefore, concomitant use of ergotamine josamycin and must be accompanied by appropriate surveillance of patients.
Vilprafen Soljutab / cyclosporin
Co-administration of josamycin and cyclosporine may cause increased cyclosporine levels in blood plasma and the creation of nephrotoxic concentration of cyclosporine in the blood. Should regularly monitor the concentration of cyclosporine in plasma.
Vilprafen Soljutab / digoxin
At a joint appointment josamycin and digoxin may increase the level of the latter in the blood plasma.
Vilprafen Soljutab / hormonal contraceptives
In rare cases, the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case it is recommended to use an additional non-hormonal contraception.
To date, no data on the specific symptoms of poisoning. In case of overdose should assume the appearance of the symptoms described in the section “Side Effects”, especially on the part of the gastrointestinal tract.
If one step is missing, you should immediately take the dose. However, if it is time for your next dose, do not take the “forgotten” dose, but should return to normal treatment. Do not take double the dose. Break in treatment or premature discontinuation of the drug reduces the chance of treatment success.
pharmachologic effect
Pharmacological group:
Antibiotic, macrolide.
The preparation is used for treatment of bacterial infections; Bacteriostatic Activity josamycin, like other macrolides, is due to inhibition of bacterial protein synthesis. When creating in inflammation in high concentrations has a bactericidal effect.
Josamycin highly active against intracellular bacteria (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila); Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphteriae), Gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), as well as against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringens). Little effect on the enterobacteria, so little effect on the natural bacterial flora of the gastrointestinal tract. Effective resistance to erythromycin. Josamycin resistance develops less often than other macrolide antibiotics.
After oral administration, josamycin rapidly and completely absorbed from the gastrointestinal tract, food intake does not affect the bioavailability. The maximum concentration in serum josamycin achieved in 1-2 hours after administration. About 15% of josamycin bound to plasma proteins. Particularly high concentrations of substance found in the lungs, tonsils, saliva, sweat and tear fluid. The concentration in the sputum concentration in plasma is greater than 8-9 times. It accumulates in bone. Passes the placental barrier, it is secreted into breast milk. Josamycin metabolized in the liver to less active metabolites and excreted primarily in the bile. Excretion of the drug in the urine than 20%.
Pregnancy and breast-feeding
Allowed to use during pregnancy and breastfeeding period indicated. The European branch of the WHO recommends josamycin as the drug of choice in the treatment of chlamydial infection in pregnant women.
Conditions of supply of pharmacies
Available on medical prescription.
side effects
On the part of the gastrointestinal tract
Rare – loss of appetite, nausea, heartburn, vomiting, diarrhea and dysbacteriosis. In the case of persistent severe diarrhea should be borne in mind the possibility of the development of antibiotics in the background a life-threatening pseudomembranous colitis.
Hypersensitivity reactions:
In very rare cases skin allergic reactions (e.g. urticaria).
Liver and ways zhelchevyvodyashih
In some cases, there was a transient increase in liver enzymes in the blood plasma, in rare cases followed by violation of the outflow of bile and jaundice.
With the hearing aid
In rare cases, the reported dose-dependent transient hearing impairment.
Other: very rarely – Candida.
special instructions
In patients with renal insufficiency treatment should be carried out taking into account the results of relevant laboratory tests.
Must consider the possibility of cross-resistance to different macrolide antibiotic (e.g., microorganisms resistant to treatment by antibiotics related in chemical structure may also be resistant to josamycin).
Storage conditions
Store in a cool dry place at a temperature not higher than 25 C.
Store the drug out of the reach of children !.
Dosing and Administration
The recommended daily dose for adults and adolescents over the age of 14 years is 1 to 2 g of josamycin. The daily dose should be divided into 2-3 doses. Starting recommended dosage is 1 g of josamycin.
josamycin recommended to prescribe a dose of 500 mg twice a day for the first 2-4 weeks, etc. In the case of ordinary and globular acne – josamycin 500 mg once daily as a maintenance treatment for 8 weeks.
Vilprafen coated tablets should be swallowed whole with a little water.
Typically, the duration of treatment is determined by the doctor. According to the World Health Organization’s guidelines for the duration of antibiotic treatment of streptococcal infections should be at least 10 days.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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