Venolek Tab n / a film about 500mg 30 pieces kanonfarma

Description

Composition
Active substance:
1 tablet contains: diosmin – 500 mg.
Excipients:
Giproloza (hydroxypropyl) -18 mg calcium hydrogen phosphate dihydrate – 65.25 mg magnesium stearate – 4 mg Sodium carboxymethyl starch – 2 mg, macrogol (polyethylene glycol 6000) 9.75 mg Microcrystalline cellulose 51 mg.
Composition of coating film: selekoat AQ-01812 30 mg, including: hypromellose (hydroxypropylmethylcellulose) 16.2 mg, macrogol (polyethylene glycol 400) 3 mg, macrogol (polyethylene glycol 6000) 3 mg, 7.5 mg of titanium dioxide, iron oxide colorant 0.15 mg of yellow, quinoline yellow dye 0.15 mg.
Description:
Tablets, film-coated from light yellow to yellow color, round, biconvex shape. At the turn of pills yellow or grayish-yellow.
Product form:
Tablets, film-coated, 500 mg.
At 10 or 15 tablets in blisters of PVC film and aluminum foil printed patent.
At 1, 3, 5, 6, the contour of cellular packages for 10 tablets, or 2, 4 blisters with 15 tablets with instructions for use placed in a pile of cardboard for packaging consumer.
Contraindications
Hypersensitivity, pregnancy (I term) (application experience is limited), lactation, children under 18 years.
Dosage
500 mg
Indications
In the combined therapy:
– to remove such signs of venous insufficiency of the lower limbs, as a feeling of heaviness and pain in the legs;
– to relieve symptoms of acute hemorrhoids.
Interaction with other drugs
Not mentioned.
Overdose
Currently, the cases of overdose have been reported.
pharmachologic effect
Pharmacodynamics:
The drug has flebotoniziruyuschim action (reduces extensibility veins increases tone vein (dose-dependent effect), reduces venous stasis), improves lymphatic drainage (increases the tone and frequency of contraction of the lymph capillaries, increases their functional density reduces lymphatic pressure), improves (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces adhesion of leukocytes to the venous wall and their migration into tissues paravenoznye improves the diffusion of oxygen and perfusion in the skin tissue, possesses anti-inflammatory action. Enhances vasoconstrictor action of adrenaline, noradrenaline, inhibit the production of free radicals, prostaglandins and thromboxane.
Pharmacokinetics:
Rapidly absorbed from the gastro – intestinal tract, detected in plasma 2 hours after dosing. The maximum plasma concentration is reached after 5 h after administration. Evenly distributed and accumulated in all the walls of the hollow fibers and subcutaneous veins of the lower extremities, to a lesser extent – in the kidneys, liver, lungs, and other tissues. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum of 9 hour after administration and is maintained for 96 hours. The half-life is 11 hours is derived buds -. 79%, intestine – 11%, with bile – 2.4%.
Pregnancy and breast-feeding
In pregnancy, the use of the drug possible. Experimental and clinical studies have shown no embryotoxic, mutagenic and teratogenic effects. So far, there were no reports of any adverse effects when using the drug in pregnant women, but it is necessary to evaluate the risks and benefits of the appointment of the drug to pregnant women.
When lactation the drug is not recommended due to lack of data on the penetration of the drug into breast milk.
Conditions of supply of pharmacies
Without recipe.
side effects
Classification of the WHO frequency of side effects: very often -> 1/10 assignments (> 10%) frequently – by> 1/100 to 1%, and
special instructions
acute attack of haemorrhoids treatment is carried out in combination with other drugs, in the absence of rapid clinical effect it is necessary to conduct an additional inspection and adjust the therapy.
Effect on the ability to drive
No Information about the negative impact of the drug on the ability to drive vehicles and other mechanisms.
Storage conditions
Store in a dry, dark place at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Before using the drug should consult a doctor.
The drug is intended for oral administration.
When varicose veins and chronic lymphovenous failure drug appoint 1 tablet per day in the morning on an empty stomach. Duration of therapy is usually 2 months.
In severe forms of chronic lymphovenous insufficiency (edema, pain, seizures, changes and trophic ulcers) treatment may be longer.
The total duration of continuous therapy should not exceed three months.
Courses of treatment is repeated in 2-3 months.
during the II and III trimester of pregnancy drug to treat chronic lymphovenous failure appoint 1 tablet 1 time a day. The duration of therapy less than 30 days. You need to stop taking the drug for 2-3 weeks before delivery.
During exacerbation of hemorrhoids drug prescribed 2-3 tablets a day with meals for 7 days.
If you missed one or more steps of the preparation, you must continue to use the drug in normal mode and in a normal dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist