Upsarin UPSA Table spike. 500mg 16 pieces

Description

Composition
Active substance:
1 tablet contains: acetylsalicylic acid 500 mg ,.
Excipients:
Sodium bicarbonate 1100.0 mg; Citric acid anhydrous 430.0 mg; Sodium citrate anhydrous 530.0 mg; Anhydrous sodium carbonate 71.5 mg; Aspartame 10.0 mg; Povidone (K30) 1.0 mg; 5.0 mg of crospovidone; orange flavor * 2.5 mg.
Description:
Round, flat with bevelled edges and a line on one side of the white pills. When dissolved in water, effervescence is observed.
Product form:
Effervescent tablets of 500 mg. 4 effervescent tablets in a strip of aluminum foil coated on the inside with polyethylene. According strip 4 together with instructions for use placed in a cardboard box.
Contraindications
Children up to age 15 years; hypersensitivity to aspirin, NSAIDs and other components of the drug; deficiency of glucose-6-phosphate dehydrogenase deficiency, phenylketonuria (preparation comprises aspartame); bronchial asthma induced by intake of salicylates and other NSAIDs history.; pregnancy (I and III trimester), breast-feeding; erosive-ulcerous lesions of the gastrointestinal tract (exacerbation), gastro-intestinal bleeding; hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura); expressed human liver, or kidney; vitamin K deficiency; glucose-galactose malabsorption; simultaneous with methotrexate at a dose of 15 mg / week or more (see section: “Interaction”); concomitant use of oral anticoagulants and acetylsalicylic acid in the dose exceeding 3 grams per day (see section: “Interaction”).
If you have one of these diseases, before using the product, be sure to consult with your doctor.
Be wary – hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer or gastrointestinal bleeding (in history), kidney and liver failure, asthma, nasal polyposis, drug allergies, pregnancy (II trimester), concomitant use of anticoagulants and acetylsalicylic acid at a dose of less than 3 grams per day, simultaneous acetylsalicylic acid and methotrexate at a dose less than 15 mg / day, metrorrhagia (acyclic uterine bleeding), hypermenorrhea (abundant and rodolzhitelnye menstruation). If you have one of these diseases, before using the product, be sure to consult with your doctor.
Dosage
500 mg
Indications
Symptomatic treatment for adults with moderate or weakly expressed pain syndrome of different origin: headache (including associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, chest radicular syndrome, muscle and joint pain, tuberculosis (pain during menstruation). Fever with colds and other infectious and inflammatory diseases in adults and children older than 15 years.
Interaction with other drugs
Acetylsalicylic acid, enhances the toxicity of methotrexate, narcotic analgesics and other NSAIDs, oral hypoglycemic drugs, heparin, anticoagulants, thrombolytics, and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole..), Triiodothyronine; reduces – uricosuric drugs (benzbromarone, sulfinpyrazone), antihypertensives and diuretics (spironolactone, furosemide). Steroids, alcohol and alcohol-containing medications increase the damaging effect on the mucous membrane of the gastrointestinal tract, increase the risk of gastrointestinal bleeding. Acetylsalicylic acid increases the concentration of digoxin, the barbiturates and the lithium in the blood plasma preparations. Antacids containing magnesium and / or aluminum hydroxide, and degrade the slow absorption of acetylsalicylic acid.
Overdose
Symptoms: In the initial stage of poisoning symptoms excitation of the central nervous system develops, dizziness, severe headache, hearing loss, blurred vision, nausea, vomiting, increased respiration. Later comes the depression of consciousness up to coma, respiratory failure, disorders of water and electrolyte metabolism.
Treatment: The patient should be hospitalized, induce vomiting or gastric lavage, activated charcoal and appoint a laxative and control of acid-base balance. Apply symptomatic treatment; in cases of severe intoxication is possible to use dialysis.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug.
Pharmacodynamics:
Anti-inflammatory, analgesic and antipyretic effects associated with inhibition of cyclooxygenase 1 and 2, regulating the synthesis of prostaglandins. Decreases aggregation, thrombus formation and platelet adhesiveness by suppressing the synthesis trombok- san A2 in platelets. Antiplatelet effect persists for 7 days after a single dose (more pronounced in males than in females).
Pharmacokinetics:
Absorption: Dissolved in water, the tablet form of the drug Upsarin Upsa® buffer solution, which, after taking the drug maintains active substance in dissolved form, preventing them from contact with the acidic environment of the stomach to move back in undissolved form and precipitate as solids on its walls. The result is more rapid and complete absorption of the drug as well as its better tolerability in comparison with conventional tablets acetylsalicylic acid. The maximum concentration of drug achieved in 15-40 minutes in plasma. Bioavailability of acetylsalicylic acid varies depending on the received dose: about 60% – to less than 500 mg dose and 90% – for doses greater than 1 g due to saturation of the reaction of hydrolysis in the liver. Acetylsalicylic acid undergoes rapid hydrolysis to form the active metabolite – salicylic acid.
Distribution: Acetylsalicylic acid and salicylic intensively distributed in the tissues; they cross the placental barrier and are found in mother’s milk. In therapeutic concentration of about 90% of salicylic acid binds with serum proteins.
Metabolism and excretion: Acetylsalicylic acid is extensively metabolized in the liver. Derived mainly from urine as salicylic acid and glucuronic acid conjugates as well as salitsilmochevoy and gentezovoy acid. The half-life of 15-20 minutes for acetylsalicylic acid and 2-4 hours – salicylic acid.
Pregnancy and breast-feeding
The drug is contraindicated in Upsarin Upsa® I and III trimester of pregnancy. Application in II trimester – with caution, only if the potential benefit outweighs the potential application risk to the fetus. Breastfeed during use of the drug is not recommended.
Conditions of supply of pharmacies
Without recipe.
side effects
The frequency of side effects is given in accordance with the following scale: very frequent – 1/10 assignments (> 10%); frequent – 1/100 assignments (> 1% and 0.1% and 0.01%, and
On the part of the gastrointestinal tract: rare: nausea, vomiting, epigastric pain, diarrhea (diarrhea), gastrointestinal bleeding (vomiting-type “coffee grounds” black “tarry” stools); decreased appetite, increased activity of “liver” transaminases, ulcers and perforation of the stomach;
From the nervous system: Rare: headache, dizziness, hearing loss, ringing in the ears.
From the blood and lymphatic system: rarely, hemorrhagic syndrome (nosebleeds, bleeding gums, purpura), increased blood coagulation time. These effects persist for 4-8 days after discontinuation of the drug and should be taken into account when planning future operations for patients.
Immune system: Rare: skin rash, bronchospasm, angioedema. Formation based haptenated mechanism “aspirin” triad (combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerance to acetylsalicylic acid and the pyrazolone series preparations);
Of the liver and biliary tract: Very rare: Reye syndrome (encephalopathy and acute fatty liver with the development of acute liver failure).
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, stop taking this medication and tell your doctor.
special instructions
In the application of preparations containing acetylsalicylic acid, acute respiratory disease caused by viral infections, there is a risk of Reye’s syndrome (encephalopathy and acute fatty liver with acute liver failure development). Symptoms of Reye syndrome are prolonged vomiting, acute encephalopathy, liver enlargement. Acetylsalicylic acid reduces the excretion of uric acid from the organism that can cause an acute attack of gout in predisposed patients. With prolonged use of the preparation should be conducted periodically CBC and analizkala occult blood, monitor the functional state of the liver. Before surgery to reduce bleeding during surgery and in the postoperative period, the drug should be discontinued for 5-7 days and put in a doctor’s reputation. Patients who observe a salt-free or low-salt diet should be noted that each tablet contains 388.5 mg (16.9 mEq) of sodium. Preparation Upsarin Upsa® comprises aspartame, which is a derivative of phenylalanine, which is dangerous for patients with phenylketonuria.
Storage conditions
In a dry place at a temperature of from 15 to 25 ° C.
Keep out of the reach of children!.
Dosing and Administration
Taken after meals dissolving tablet / pill in 100-200 ml of water.
Adults and children over 15 years: 1 tablet (500 mg) to receive up to 6 times per day. In severe pain and high temperature – 2 tablets (1 g) to receive up to 3 times a day. The minimum interval between doses should be 4 hour. The maximum daily dose should not exceed 3 g (6 tablets)
Elderly: 1 tablet (500 mg) to receive up to 4 times a day. In severe pain and high temperature – 2 tablets (1 g) at reception. The minimum interval between doses should be 4 hour. The maximum daily dose should not exceed 2 g (4 tablets).
Duration of treatment (without consultation with a physician) should not exceed 5 days when administered as an analgesic and more than 3 days – as an antipyretic agent.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist