Tab 250mg pyrantel 3 pcs Polpharma

Description

Composition
Active substance:
1 tablet contains: pyrantel 250 mg (as pyrantel embonate 720 mg).
Excipients:
1 tablet contains: ethyl cellulose, povidone, magnesium stearate, talc, orange flavoring, potato starch.
Description:
yellow tablet with gray-green tint, round, flat, with Valium and a facet. The tablets have a faint smell of orange.
Tablets darken on exposure to light, changing the color to yellow-brown. Slight marbling.
Product form:
Tablets of 250 mg. 3 tablets in contour bezgyachakova package (strip) of aluminum foil laminated with polyethylene.
By the Strip 1 together with instructions for use are placed in a cardboard box.
Contraindications
• Hypersensitivity to the drug; • myasthenia gravis (treatment period); • Children under 3 years of age (for a given dosage form).
Carefully
Pregnancy, lactation, liver failure.
Dosage
250 mg
Indications
• Ascariasis • Enterobiasis ankilostomidoze • • • necatoriasis Trichuriasis.
Interaction with other drugs
Pyrantel should not be used together with piperazine. These agents act antagonistically.
Pyrantel increases the concentration of theophylline in plasma.
Overdose
No cases of overdose reported.
In case of overdose symptomatic treatment should be taken.
pharmachologic effect
Pharmacological group:
Anthelmintic.
Pharmacodynamics:
Pyrantel is an anthelmintic agent acting on nematodes.
It causes neuromuscular blockade in sensitive to it helminths, which facilitates their removal from the digestive tract without the excitement and stimulation of migration of infected worms.
The drug acts on the parasites in an early stage of development and their mature forms, has no effect on the larvae during their migration in the tissue.
Pyrantel is highly effective against infestations caused pinworms (Enterobius vermicularis), hookworms (Ancylostoma doudenale, Necator americanus), trichuriasis against pathogens (Trichostrongylus orientalis and Trichostrongylus colubriformis) and ascariasis (Ascaris lumbricoides).
Pharmacokinetics:
Pyrantel is very poorly absorbed from the digestive tract.
The concentration of drug in plasma following oral administration of a single dose of 10 mg / kg body weight, is 0.005 – 0.13 g / ml for 1 – 3 hours.
There are no data on the penetration of the drug through the placenta and milk in lactating women, as well as on the distribution of the drug in tissues and body fluids (theoretically, the resorption of the drug is the minimum).
The minimum amount of drug resorbed from the intestinal tract is partially metabolized in the liver to N-methyl-1,3-propanediamine.
About 93% of the oral dose of the drug is excreted unchanged in the intestine and not more than 7% by kidneys in unchanged form or in the metabolite N-methyl-1,3-propanediamine.
Pregnancy and breast-feeding
There are no controlled studies of the use of Pyrantel in pregnant women and women who are breastfeeding, and the drug should be used only if the potential benefit to the mother than the potential risk to the fetus.
Conditions of supply of pharmacies
On prescription.
side effects
Side effects are rare, they are short-lived and disappear after cessation of treatment.
The majority of side effects seen with the digestive tract: nausea, vomiting, lack of appetite, diarrhea, stomach pain and cramps.
Rarely – headache, dizziness, drowsiness or insomnia, fatigue, rash, fever, transient increase in the concentration of AST in serum.
In rare cases, we observed hearing loss, hallucinations, with confusion and paresthesia (the relationship of these symptoms with taking the drug has not been proven).
special instructions
Upon receiving pyrantel not prescribed laxatives. When treating enterobiosis should be treated at the same time all the persons living together. Careful hygiene compliance (household cleaning and cleaning clothes for the destruction of helminth eggs) is the prevention of reinfection.
14 days after treatment with pyrantel should conduct monitoring parasitological research.
Given the potential side effects in the nervous system during use of the drug must be taken when activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside. The drug is used during or after a meal, thoroughly chewing the pill, washed down with a glass of water 1.
If not assigned to the other treatment regimen, depending on the age and weight of the patient, following recommended dosage: 3-6 years – 1 tablet (250 mL) 6 – 12 – 2 tablets (500 mg) over 12 years and adult weighing 75 kg – 3 tablets (750 mg) adults weighing over 75 kg – 4 tablets (1000 mg)
In order to avoid a repetition rate samoinvazii permitted 3 weeks after the first dose.
When isolated ascariasis recommended application pyrantel 5 mg / kg dose.
Ascariasis and enterobioze and mixed infestations by these parasites, the dose intended for the entire course (estimated – 10 mg / kg) is used singly.
When ankilostomidoze, combined with necatoriasis ascariasis combined helminth or other lesions pyrantel used within 3 days to 10 mg / kg per day.
When massive infestations Necator americanus recommended dose of 20 mg / kg body weight for 2 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist