Septanazal Nazal Spray. 0.05mg + 5mg / 10ml dose 90doz fl.p / e 1 piece with the metering device

Description

Composition
Active substance:
1 dose spray contains: dexpanthenol Xylometazoline hydrochloride 5.00 mg 0.05 mg.
Excipients:
Potassium dihydrogenphosphate, disodium hydrogenphosphate dodecahydrate, purified water
1 dose is 0.1 ml.
The nominal number of doses of the drug in the vial – 90 doses.
Description:
The clear, colorless solution.
Product form:
Nasal spray metered (for children), 5 mg + 0.05 mg / dose. 10 ml (90 doses) of the drug in the vial of high density polyethylene with a metering device (pump), and a transparent protective cap of the composite material. 1 vial together with instructions for use placed into cardboard pack.
Contraindications
Hypersensitivity to any component of the drug; hypertension, tachycardia expressed arteriosclerosis, glaucoma; atrophic rhinitis; hyperthyroidism, porphyria, prostatic hyperplasia, surgical interventions in the meninges (history), the simultaneous application of monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants; pregnancy, lactation, children under 2 years of age;
Precautions: diabetes, pheochromocytoma, diseases of the circulatory system (including ischemic heart disease, angina), increased sensitivity to the action of adrenergic agents, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure (BP).
Dosage
0.05 mg + 5 mg / dose
Indications
Acute respiratory illness with symptoms of rhinitis, acute allergic rhinitis, vasomotor rhinitis, sinusitis, otitis media (in combination therapy to reduce the nasopharyngeal mucosa edema), to facilitate the rinoskopii, restore impaired nasal breathing after surgery in the nasal cavity.
Interaction with other drugs
The simultaneous use of MAO inhibitors and tricyclic antidepressants may lead to increased blood pressure, due to the impact of these drugs on the cardiovascular system.
Overdose
symptoms:
In cases of overdose or accidental intake of the following symptoms may occur inside: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmias, circulatory collapse, cardiac arrest, increased blood pressure, pulmonary edema, impaired respiratory function, hallucination.
Patients can also appear symptoms of oppression on the part of the central nervous system, accompanied by drowsiness, decrease in body temperature, bradycardia, shock, respiratory arrest and coma.
Treatment: the use of activated charcoal, gastric lavage, oxygen ventilation. To reduce the blood pressure is applied 5 mg phentolamine 0.9% sodium chloride solution by intravenous or 100 mg of phentolamine inside. Vasoconstrictive drugs are contraindicated. If necessary, apply anti-pyretic and anti-convulsants ..
pharmachologic effect
Pharmacological group:
Nasal agent treatment.
Pharmacodynamics:
Xylometazoline – local vasoconstrictor (decongestant) with alpha-Adrenomimeticalkie activity causes vasoconstriction of nasal mucosa, nasal restores patency eliminates nasal congestion, nasal breathing easier. Xylometazoline action usually occurs within a few minutes after its application and continues until 10 hours. Deksapantenol – vitamin B group, a derivative of pantothenic acid. Dexpanthenol is converted in the body to pantothenic acid, which is a component of coenzyme A (CoA), and is involved in the processes of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins, stimulates the restoration of the skin and mucous membranes, normalizes cell metabolism, accelerates mitosis and increases the strength of collagen fibers. Provides regenerating, metabolic and weak anti-inflammatory action.
Pharmacokinetics:
Xylometazoline when applied topically practically not absorbed. plasma concentrations are so small that they can not identify with modern analytical methods.
Deksapantenol when topically applied skin rapidly absorbed and converted into pantothenic acid, binds to plasma proteins (mostly with beta-globulin and albumin). Its concentration in the blood – 0.5-1 mg / ml, in serum – 100 g / l. Pantothenic acid is not subjected to metabolism in the body (except for inclusion in the CoA) is output unchanged.
Pregnancy and breast-feeding
Use of the drug SeptaNazal during pregnancy and lactation is contraindicated.
Conditions of supply of pharmacies
Without a prescription.
side effects
With frequent or prolonged use of irritation and / or dryness of the mucosa of the nasopharynx, burning, tingling, sneezing, hypersecretion, allergic reactions, edema of nasal mucosa, nausea, vomiting, headache, dry rhinitis, palpitations, povyshenme blood pressure, tachycardia, insomnia, visual disturbances, depression (with prolonged use of high doses).
special instructions
Before use, clean the nasal passages.
Do not apply more than 7 days. The duration of the drug in children is established after consultation with the doctor.
It does not contain preservatives. After opening the drug vial must be used within 12 weeks
Effects on ability to perform potentially hazardous activities that require attention and fast reactions (eg, road management, work with moving machinery).
During the period of the drug should take precautions or avoid driving and busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
At temperatures above 25 C, in the original package.
Keep out of the reach of children.
Dosing and Administration
Intranasally.
For children from 2 to 6 years.
One at the metered-spray in each nostril 3-4 times a day.
The duration of therapy 5-7 days
Before use, remove a protective cap. Prior to starting the spray or after a long interval must repeatedly press a pump dispensing device until a uniform dispersion.
Insert the tip of the bottle vertically in the nasal passage, take a slow breath through the nose, while pressing once on a pump dispensing device. Repeat the procedure in the other nostril. After application of the tip should be wiped with a paper towel and close the protective cap.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist