Rebagit tab n / 100mg film about 30 pc

Description

Composition
Active substance:
rebamipide 100.00 mg
Excipients:
mannitol, croscarmellose sodium, pregelatinized starch, sodium lauryl sulfate, citric acid, talc, magnesium stearate, film coating: Opadry White 03B28796 (hypromellose 6 cP, Titanium dioxide, Macrogol 400).
Description:
Round, biconvex tablets, film-coated white or almost white.
Product form:
Tablets, film-coated, 100 mg.
10 tablets in a blister of aluminum foil. 3 blisters together with instructions for use in a cardboard pack.
Contraindications
Individual intolerance ribamipida or other formulation components.
Pregnancy.
Lactation.
Children under the age of 18 years.
Carefully
We recommend caution when first assigning rebamipide in patients with advanced age in connection with the possibility of hypersensitivity to the drug.
Dosage
100 mg
Indications
Stomach ulcer. Chronic gastritis with increased acid-forming function of the stomach in the acute stage, erosive gastritis. Prevention of damage to the mucous membrane in patients receiving NSAIDs. It can be used as part of combination therapy.
Interaction with other drugs
In applying the composition of rebamipide in conventional regimens of patients with infection by Helicobacter pylori, eradication therapy efficiency significantly increases.
Reactions interaction with other drugs have not been studied.
Overdose
Symptoms of overdose rebamipide not described to date information about cases of intentional overdose have been reported. Nausea, vomiting, abdominal pain, diarrhea or constipation, headache.
assistance measures: the specific antidote is known. In the case of an overdose should be rinsed stomach and symptomatic therapy.
pharmachologic effect
Pharmacological group:
gastroprotective agent
Pharmacodynamics:
Rebamipide increases the content of prostaglandin E2 (PGE2) in the gastric mucosa, and increases the content of PGE2 and GI2 gastric contents. It exerts a cytoprotective effect against gastric mucosa damaging effects of ethanol, acids and alkalis, acetylsalicylic acid. Contributes to the activation of enzymes that accelerate the biosynthesis of glycoproteins of high molecular weight, and increases the content of slime on the surface of the stomach wall. Helps to improve the blood supply of gastric mucosa, activates its barrier function, activates alkaline gastric secretion, enhances proliferation and exchange of epithelial cells of the stomach, mucous clears from hydroxyl radicals and superoxides suppresses,
produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects the stomach lining against attack by bacteria, it renders gastroprotective effect when exposed to mucous nonsteroidal antiinflammatory drugs (NSAIDs).
Pharmacokinetics:
Absorption by ingestion – high. After receiving 100 mg peak plasma concentration (Cmax) is achieved after about 2 hours, and 340 ng / ml. The half-life (T1 / 2) is about 1.0 hours. Repeated preparation methods do not lead to its accumulation in the body. Approximately 10% of the drug is excreted by the kidneys, preferably in an unmodified form. When receiving a dose of 600 mg is possible to isolate the traces of the hydroxylated metabolite.
In in vitro experiments indicated that between 98.4% to 98.6% of the drug binds to the plasma protein.
Pregnancy and breast-feeding
Security applications rebamipide is not proved during pregnancy. Do not use during pregnancy. Since rebamipide passes into breast milk, it should stop breast-feeding or to solve the problem of the artificial feeding of the child, if necessary, the appointment of rebamipide mother during lactation.
Conditions of supply of pharmacies
By prescription.
Special precautions for the destruction of unused medicine or drug with expired shelf life is required.
side effects
On the part of the gastrointestinal tract: constipation, flatulence, diarrhea, nausea, vomiting, abdominal pain, taste disturbance, heartburn.
Liver: signs of liver dysfunction, increased serum glutamic alanine aminotransferase (ALT) and aspartate aminotransferase serum glutamic (AST).
From hemopoiesis system: a leukopenia, granulocytopenia.
Allergic reactions: itching, skin rash, eczema rashes.
Other: menstrual disorders.
special instructions
Effects on ability to drive vehicles and other mechanisms
Effects of the drug on the rate of psychomotor reactions, and / or the ability to drive vehicles or to study the mechanism. In the case of the drug should be careful about driving a car and other activities that require full attention.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children!
Dosing and Administration
Inside, 1 tablet 3 times a day, with a small amount of liquid. The course of treatment is 2-4 weeks, if necessary, can be extended to 8 weeks.
The drug has no singularities action when the first reception or when it is canceled.
At the admission of a single dose should take the following dose at the scheduled time, do not take double the dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist