Otolorin ushn drop. 10ml vial

Description

Composition
Active substance:
1 ml solution contains:
Procaine hydrochloride 20.0 mg Boric acid 30.0 mg.
Excipients:
0.1 M sodium hydroxide solution to pH 4.5-6.0, 70% Ethanol to 1 ml.
Description:
Transparent colorless or lightly colored liquid with a characteristic odor.
Product form:
Ear drops.
To 10 ml in a glass bottle, a sealed lid with pipette (dropper).
1 bottle together with instructions for use in a stack of cardboard.
Contraindications
Increased sensitivity to the drug; – idiosyncrasy; – pregnancy; – the period of breast-feeding; – childhood; – Chronic renal failure; – violation of the integrity of the eardrum.
Carefully
May decrease the antimicrobial action of sulfa drugs in the case of simultaneous application of drug Otolorin.
Indications
Outer acute and chronic otitis media without damaging the tympanic membrane.
Interaction with other drugs
Procaine metabolite (para-aminobenzoic acid) is an antagonist of sulfonamides.
Overdose
In case of overdose, prolonged use and in case of violation of renal function may cause acute and chronic toxic effects: nausea, vomiting, diarrhea, skin rash, headache, confusion, urinary disorders, in rare cases, shock.
Treatment: symptomatic.
pharmachologic effect
Pharmacological group:
Antiseptic + local anesthetic.
Pharmacodynamics:
Combined preparation for topical antiseptic and disinfectant action and moderately reduces the pain. Boric acid has an antiseptic, fungistatic action. It has little irritating effect on granulation tissue. Procaine – local anesthetic with mild anesthetic activity and a large therapeutic breadth action. It is a weak base, blocking sodium channels inhibits the generation of pulses in the sensory nerve endings, and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without significant effect on the resting potential. Suppresses conduct not only painful, but the momentum of other modalities.
Pharmacokinetics:
Boric acid is absorbed through the intact skin, the wound surface, mucous membrane. In young children are particularly well penetrates the skin and mucous membranes (described deaths in case of accidental ingestion or application on intact skin). Return slowly (if repeated administration koumouliruet). About 50% is excreted in the urine for 12 hours, the residue – within 5-7 days. Procaine undergoes a complete systemic absorption. The degree of absorption depends on the location and the route of administration (particularly by vascularization and blood flow in the introduction) and total dose (the amount and concentration). Rapidly hydrolyzed liver and plasma esterases to form two major pharmacologically active metabolites: diethylaminoethanol (possesses moderate vasodilating action) and para-aminobenzoic acid (PABA) (a competitive antagonist sulfonamide chemotherapeutic drugs and may weaken their antimicrobial effect). The half-life 30-50 s, neonatal – 54-114 s. Excreted mainly by the kidneys as metabolites derived not more than 2% of unchanged.
Pregnancy and breast-feeding
Use of the drug during pregnancy and breast-feeding period is contraindicated.
Conditions of supply of pharmacies
Without a prescription.
side effects
Allergic reactions, long-term use may occur headache, nausea, vomiting, diarrhea, in rare cases, a state of shock.
Possible local reactions such as itching, burning, which extend in 1-2 minutes and does not require withdrawal of the drug.
In the case of use in a perforated eardrum, the drug may make contact with the bodies of the middle ear and cause toxic reactions following: nausea, vomiting, skin redness, itching, hives, edema, deafness, balance disorder, mental confusion.
special instructions
Avoid contact with mucous membranes.
Before the start of the drug is necessary to ensure the integrity of the eardrum. In the case of use in a perforated eardrum, the drug may make contact with the bodies of the middle ear and cause toxic reactions.
Effect on vehicles and machinery control ability During treatment with caution when performing dangerous activities requiring high concentration and psychomotor speed reactions (management of vehicles, working with moving machinery).
Storage conditions
At temperatures above 25 ° C, away from the fire. Keep out of the reach of children.
Dosing and Administration
In the ear canal.
Adults: 2-3 drops into the ear 2-3 times a day.
Duration of therapy: no more than 7 days.
Before use, ear drops recommended to warm the bottle by holding it in hand, to avoid unpleasant sensations associated with hitting a cold fluid in the ear.
Drops Bury patient lying with an upturned ear; after the procedure the patient should be in a few minutes remain in this position.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist