Okomistin drops Ch. 0.01% 10ml vial, cap.

Description

Composition
Active substance:
Benzyldimethyl [3- (miristoilamino) propyl] ammonium chloride monohydrate (relative to anhydrous substance) – 0.01 g
Excipients:
Sodium chloride – 0.90 g Water purified to 100 ml
Description:
Colorless transparent liquid
Product form:
Okomistin®, eye drops, ear, nasal in 10 ml plastic bottles, sealed with a cork-screw-cap and a dropper with the first control opening.
1 Dropper bottle with instructions for use in a pile of cardboard.
Contraindications
Individual sensitivity to the drug.
Indications
Ophthalmology
Okomistin®, eye drops, ear, nasal recommended for complex treatment of infectious processes of the anterior eye section (blepharitis, conjunctivitis, keratitis, keratouveitis), eye injuries, eye burns (thermal and chemical); in the preoperative and postoperative periods for treatment and prevention of inflammatory lesions of the eye.
Prevention of neonatal ophthalmia, including gonococcal and chlamydial.
otorhinolaryngology
The drug used in treatment of acute sinusitis / rhinosinusitis, chronic sinusitis, exacerbation / rhinosinusitis, acute rhinitis; acute and chronic otitis externa, chronic suppurative mezotimpanita, otomycosis.
Interaction with other drugs
In a joint application Okomistin® increases the effectiveness of topical antibiotics.
Studies have drug interactions with other drugs have not been conducted.
Overdose
I was not observed.
pharmachologic effect
Pharmacological group:
Antiseptic
Pharmacodynamics:
The main active substance is an antiseptic formulation Okomistin® benzyldimethyl-miristoilamino-propylammonium having strong antimicrobial activity against gram-positive and gram-negative, aerobic and anaerobic bacteria in a monoculture and the microbial association, including multidrug-resistant hospital strains to antibiotics. The drug acts on a chlamydia, fungal pathogens, as well as herpes viruses, adenoviruses. The preparation is more effective against Gram-positive bacteria, r. H .: staphylococci, streptococci.
It has antifungal action on ascomycetes of the genus Aspergillus and the genus Penicillium, the yeast (Rhodotorula tubra, Torulopsis glabrata) and drozhzhevidnye (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, T. schoenleini, T. violaceum, Epidermophyton Kaufman-Wolf, E, floccosum, Microsporum gypseum , Microsporum canis), as well as other pathogenic fungi (e.g., Pityrosporum orbiculare (Malassezia furfur)) as monocultures and microbial associations including fungal microflora with resistance to chemotherapeutic drugs.
The operation of benzyldimethyl-miristoilamino-propylammonium lies direct hydrophobic interaction of the molecule with a lipid membranes of microorganisms, resulting in their destruction and fragmentation. In this part of the molecule benzyldimethyl-miristoilamino-propylammonium, plunging into the hydrophobic region of the membrane, it destroys nadmembranny layer loosens the membrane and increases its permeability to krupnomolekulyarnyh substances modifies the enzymatic activity of the microbial cells, inhibits enzymatic system which leads to inhibition of activity of microorganisms and their cytolysis. Benzyldimethyl-miristoilamino-propylammonium has a high selectivity of action against microorganisms as virtually no effect on the human cell membrane, which is associated with a different structure of the latter – a much greater length of lipid radicals, sharply restrict hydrophobic interaction benzyldimethyl-miristoilamino-propylammonium with cells. Under the action of the drug decreases resistance of bacteria and fungi to antibiotics. Benzyldimethyl-miristoilamino has anti-propylammonium and immunoadjuvant effect, enhances local defense responses, regenerative processes, activates the nonspecific defense mechanisms due to local modulation of cellular and humoral immune response.
Pharmacokinetics:
The drug has a local effect. Data on the possible penetration into the bloodstream absent.
Pregnancy and breast-feeding
It can be used during pregnancy.
Information about the negative impact of the drug during lactation is not.
Children
The drug can be used in pediatric practice.
Conditions of supply of pharmacies
Available on medical prescription.
side effects
Allergic reactions. In some cases it may be a sense of light burning, discomfort, which are themselves in 15-20 seconds and do not require discontinuation of therapy.
In the event of any adverse events should consult a doctor.
special instructions
Contact lenses should be removed immediately prior to instillation of the preparation Okomistin® wear and no earlier than 15 minutes after instillation.
In order to avoid contamination and cross-contamination, do not use one bottle for the simultaneous treatment of infections of the eye, nose and / or ears. To prevent contamination of the drug solution by instillation to patients should avoid contact with the eye dropper tip and the skin. Use dropper vial more than one person may spread infection.
The effect on the ability of control of vehicles and mechanisms
After the drug may be a temporary reduction in clarity of vision and prior to its recovery is not recommended to drive and engage in activities that require attention and reaction.
Storage conditions
Store at a temperature not higher than 25 ° C. Keep out of the reach of children. Shelf life after opening – 1 month.
Dosing and Administration
Ophthalmology
Locally. A drug treatment to Okomistin® instilled into the conjunctival sac of 1-2 drops 4-6 times daily until clinical recovery.
With prophylactic drug instilled for 2-3 days before surgery and within 10-15 days after surgery 1-2 drops 3 times a day.
In the treatment of eye burns, after washing with plenty of water, is carried out frequent instillation (every 5-10 minutes) for 1-2 hours. For further treatment preparation is applied 1-2 drops 4-6 times daily.
In pediatric patients, for the treatment of bacterial conjunctivitis in children aged 3 years, Okomistin® instilled into the conjunctival sac of 1 drop up to 6 times a day for 7-10 days.
For the prevention of ophthalmia in newborns immediately after birth instill 1 drop in each eye drug 3 times with an interval of 2-3 minutes.
otorhinolaryngology
Locally. In acute sinusitis / rhinosinusitis, chronic sinusitis, exacerbation / rhinosinusitis, acute rhinitis, nasal mucosal infection drug Okomistin® instilled 2-3 drops into each nostril every 4-6 hours; children under 12 years old – 1-2 drops in each nostril 4-6 times a day. The course of treatment up to 14 days.
In acute and chronic otitis externa, otomycosis Okomistin® drug is instilled into the ear canal 5 drops 4 times a day; children under 12 years old – 2-3 drops 4-6 times a day; or instead instillation in the external auditory meatus administered turunda gauze soaked preparation 4 times per day. The course of treatment is 10 days.
In chronic mezotimpanitah used in complex treatment using hardware ultrasonic irrigation or introduction into the tympanic cavity in conjunction with antibiotics.
In the absence of positive dynamics (increase in the severity or the appearance of new signs / symptoms of the disease, the occurrence of complications) for 3-4 days of therapy with the drug Okomistin® need to see a doctor!
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist