Nazivin Nazal Spray. dosed 22.5mkg / 10ml dose vials

Description

Composition
Active substance:
Oxymetazoline hydrochloride 22.5 g.
Excipients:
citric acid monohydrate 27.4 g, sodium citrate dihydrate, 172.0 g glycerol (85%) 1095.66 g, benzalkonium chloride (50% solution) 4.5 g, purified water 44037 g.
Sum: 45359.06 mg equivalent of 45 microliters.
Description:
Almost transparent, from almost colorless to slightly yellow solution.
Product form:
Nasal spray metered 22.5 ug / dose. 10 ml (at least 143 doses / vial) drug in a brown glass bottle, III hydrolytic class with the metering device of polyethylene and stainless steel and the protective kryshkoy.1 vial with instructions for use placed in a cardboard box.
Contraindications
Atrophic rhinitis; closure glaucoma; hypersensitivity to the components preparata.Detsky age of 6 years.
Carefully
Patients taking monoamine oxidase inhibitors and other drugs that enhance blood pressure in a period of 10 days after application; at elevated intraocular pressure, atherosclerosis, tachycardia, pheochromocytoma, pregnancy and lactation, in severe forms of cardiovascular diseases (hypertension, angina pectoris); thyrotoxicosis and diabetes.
Dosage
22.5 ug / dose
Indications
• treatment of acute respiratory diseases, accompanied by rhinitis;
• allergic rhinitis;
• vasomotor rhinitis;
• to recover the drain during inflammation of the paranasal sinuses of the nasal cavity, eustachian, otitis media;
• to eliminate the edema before diagnostic procedures in the nasal passages.
Interaction with other drugs
When concomitant administration of MAO blockers and tricyclic antidepressants – increased blood davleniya.Sovmestnoe appointment of other vasoconstrictor drugs increases the risk of side effects.
Overdose
After a significant overdose or accidental intake of the following symptoms may appear inside: pupillary constriction, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, collapse, depression of cardiac activity, hypertension, pulmonary edema, respiratory disorder. In addition, mental disorders can occur, as well as depression of the central nervous system, accompanied by drowsiness, decrease in body temperature, bradycardia, hypotension, respiratory arrest and coma vozmozhnymrazvitiem. In overdose associated with the ingestion of the drug is assigned gastric lavage, activated charcoal.
pharmachologic effect
Pharmacological group:
decongestant agent – vasoconstrictor (alpha-agonists)
Pharmacodynamics:
Preparation Nazivin® (oxymetazoline) has a vasoconstrictive action. When applied topically to the inflamed nasal mucosa decreases its swelling and nasal discharge. Restores dyhanie.Ustranenie nasal edema nasal mucosa promotes restoration aeration nasal sinuses, middle ear cavity, which prevents the development of bacterial complications (sinusitis, sinusitis, otitis media). For topical intranasal application of therapeutic concentrations, non-irritating and does not cause flushing nasal mucosa. Preparation Nazivin® nasal spray metered 22.5 ug / dose operates with 25 seconds. The duration of action of the drug to 12 hours. The results of double-blind placebo-controlled study in patients with acute viral rhinitis aged 12-70 years showed that the use of the drug Nazivin® nasal spray metered 22.5 ug / dose reducing the median duration rhinitis from 6 to 4 days.
Pharmacokinetics:
For topical intranasal application oxymetazoline has no systemic action. The half-life when oxymetazoline intranasal administration is 35 hours. 2.1% oxymetazoline excreted in the urine, and about 1.1% in the feces.
Pregnancy and breast-feeding
When used in pregnancy or breastfeeding should not exceed the recommended dosage. The drug should only be used after careful assessment of risks and benefits to mother and fetus.
Conditions of supply of pharmacies
without recipe.
side effects
Sometimes: burning or dryness of the nasal membranes, sneezing. In rare cases: after pass effect of the Nazivina®, a strong sense of “stuffiness” of the nose (reactive hyperemia). Multiple overdose by topical nasal use sometimes leads to systemic sympathomimetic effects such as increased heart rate (tachycardia) and high blood pressure. In very rare cases we observed anxiety, insomnia, fatigue, headaches and toshnota.Dlitelnoe continuous use of vasoconstrictors may cause tachyphylaxis, atrophy of nasal mucosa, and nasal mucosa edema returnable (rhinitis medicamentosa).
special instructions
Avoid long-term use and overdose, especially in children.
Effect on driving ability
After prolonged use or reception means from rhinitis comprising oxymetazoline, at dosages higher than recommended, we can not exclude the overall impact on the cardiovascular system and the central nervous system. In these cases, the ability to operate a vehicle or equipment can be reduced.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Adults and children over 6 years: 1 injection in each nostril 2-3 times a day. If symptoms worsen or there is no improvement within 3 days, you should consult with your doctor. At the recommended dose without consulting your doctor, do not use more than 7 days. Doses above recommended can be used only under supervision vracha.Odno injection volume of 45 ul containing 22.5 micrograms oxymetazoline hydrochloride.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist