Nazik Nazal Spray. scrapper. Adult 0.1 + 5mg / 10ml dose vials

Description

Composition
Active substance:
10 ml of the preparation contains: xylometazoline hydrochloride, 10 mg, 500 mg dexpanthenol.
Excipients:
Benzalkonium chloride (as a 50% solution) 4 mg, 85.3 mg of potassium dihydrogenphosphate, disodium hydrogenphosphate dodecahydrate 2.70 mg Purified water 9398.0 mg.
Description:
Transparent, colorless liquid.
Product form:
Spray 10 ml.
Contraindications
Hypersensitivity to the drug, hypertension, tachycardia, expressed atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions in the meninges (history).
Dry inflammation of the nasal mucosa (rhinitis sicca).
Children up to age 6 years.
Carefully.
Only after careful evaluation of the benefit / risk of the drug can be used:
-bolnym receiving monoamine oxidase inhibitors (MAO inhibitors), or other drugs that increase blood pressure;
-bolnym with pheochromocytoma;
-bolnym with metabolic disorders (e.g., hyperthyroidism, diabetes).
Dosage
50 mg + 1 mg / ml
Indications
Acute allergic rhinitis, vasomotor rhinitis, acute respiratory disease with symptoms of rhinitis, sinusitis, hay fever; Otitis media (to minimize swelling of nasal mucosa).
Preparing the patient for diagnostic procedures in the nasal passages and restoration of the nasal breathing after surgery in the nasal cavity.
Interaction with other drugs
Concomitant use of inhibitors of monoamine oxidase type tranylcypromine or tricyclic antioxidants may lead to increase in blood pressure due to the impact of these drugs on the cardiovascular system.
Overdose
In cases of overdose or accidental oral administration may experience the following symptoms: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmias, circulatory collapse, cardiac arrest, hypertension, pulmonary edema, impaired respiratory function, mental disorders.
Patients may also appear from the symptoms of CNS depression accompanied by drowsiness, decrease in body temperature, bradycardia, hypotension, shock type, cessation of breathing and coma. Treatment.
The use of activated charcoal, gastric lavage, oxygen ventilation. To reduce the blood pressure is prescribed 5 mg of phentolamine in a physiological solution by slow intravenous injection or orally 100 mg of phentolamine. Vasoconstrictor drugs are contraindicated. If necessary apply antipyretic and anticonvulsants.
pharmachologic effect
Pharmacological group:
Decongestant agent.
Pharmacodynamics:
Rinologichesky drug combination of alpha-sympathomimetic agent and the vitamin, for topical application to the nasal mucosa.
Xylometazoline hydrochloride – imidazole derivative is alpha agonists, constricts blood vessels of the nasal mucosa, eliminating edema and hyperemia mucosa. Relieves nasal breathing in rhinitis.
Effect of the drug typically occurs within 5-10 minutes after application and lasts for several hours.
Dexpanthenol – Vitamin B group – a derivative of pantothenic acid. Dexpanthenol is converted in the body to pantothenic acid, which is a component of coenzyme A, and is involved in the processes of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins; It stimulates the regeneration of the skin, mucous membranes, normalizes cell metabolism, accelerates mitosis and increases the strength of collagen fibers. Provides regenerating, metabolic and weak anti-inflammatory action.
In an experiment on animals (rats with deficiency of dexpanthenol) was found effective impact dexpanthenol in skin trophism. When applied topically dexpanthenol / panthenol able to meet increased demand for pantothenic acid in skin or mucous membranes.
Pharmacokinetics:
Xylometazoline hydrochloride when applied topically practically not absorbed, the plasma concentrations are so small that they can not be determined by modern analytical methods. Dexpanthenol for topical application of skin is rapidly absorbed and converted into pantothenic acid, binds to plasma proteins (mostly with beta-globulin and albumin). Its concentration in the blood – 0.5-1 mg / l in the blood serum – 100 g / l. Pantothenic acid is not subjected to metabolism in the body (except for inclusion in Co-A) is output unchanged.
Pregnancy and breast-feeding
Given that no evidence of reproductive toxicity of the drug during pregnancy and lactation is not recommended for use.
Conditions of supply of pharmacies
Without recipe.
side effects
Respiratory, thoracic and mediastinal disorders.
Very rarely, temporary mild irritation (burning or dryness of the nasal mucosa), especially in patients with hypersensitivity.
Very rarely or in single messages: increased edema nasal mucosa.
With frequent and / or prolonged use or when using high doses of Xylometazoline hydrochloride may receive burning paresthesia and the nasal mucosa, the development of reactive edema with rhinitis medicamentosa. This effect can occur within 5 days from the start of treatment and during long-term use lead to permanent damage to the mucosa to form scabs (rhinitis sicca).
Disorders of the nervous system.
Rarely or very rarely: headache, vomiting, insomnia or fatigue, blurred vision; depression (with prolonged use at high doses).
Violations of the cardiovascular system:
Rare: palpitations, tachycardia, increased blood pressure. Very rare: allergic reactions may occur.
special instructions
Before use, clean the nasal passages. Do not apply more than 7 days.
Effects on ability to drive and use machines
Prolonged use or use at high doses can not be excluded systemic drug reactions, including effects on the cardiovascular system and central nervous system.
In such cases, the ability to drive and operate machinery may be impaired.
Storage conditions
At a temperature of not higher than 25 C.
Dosing and Administration
Intranasally.
For adults and children older than 6 years.
When using a vial with a metering pump action device packaged separately.
Remove the pump-action dispensing device from its packaging. Uncorking vial, the vial neck screwed pas metering device to remove a protective cap. The vial is ready to use.
Prior to starting the spray repeatedly press a pump dispensing device until a uniform dispersion.
When using a bottle with a built-in pump-action dispensing device.
Remove the cap from the integrated pump-action dispensing device. The vial is ready to use.
Prior to starting the spray several times to press the inside pump-action dispensing apparatus until a uniform dispersion. In the application of spray bottle must be held upright.
During the injection you need to easily inhale nose. One injection into each nostril 3-4 times a day. Duration of therapy 3- 5 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist