Kolbiotsin ointment Ch. 5g tube

Description

Composition
Active substance:
100 g of the preparation contains: Tetracycline – 0.5 g, chloramphenicol – 1.0 g sodium kolistimetat – 18000000 ME ;.
Excipients:
Anhydrous Lanolin – 15.0 g of liquid paraffin – 15.0 g White soft paraffin to 100.0 g
Description:
Soft mass of light yellow color.
Product form:
Eye ointment.
5 g of the ointment in an aluminum tube with a plastic tip, closing plastic cap with tamper-evident. The tube together with instructions for use in a cardboard pack.
Contraindications
Hypersensitivity to the drug; the liver, kidneys: In rare cases, long-term use of bone marrow hypoplasia; pregnancy and lactation; Children under 8 years old.
Indications
In the complex treatment of: bacterial blepharitis, blepharoconjunctivitis, bacterial conjunctivitis (catarrhal, purulent), chlamydial conjunctivitis, bacterial keratitis, purulent corneal ulcer, dacryocystitis.
Interaction with other drugs
When applied topically kolbiotsin pharmacological interactions with other drugs is not revealed.
Overdose
Data on overdose of the drug available.
pharmachologic effect
Pharmacological group:
The antimicrobial agent combined.
Pharmacodynamics:
Combined antibacterial drug.
Chloramphenicol – broad spectrum antibiotic inhibits protein synthesis sensitive microorganisms; active against gram-positive and gram-negative bacteria, Mycoplasma spp., Rickettsia spp., Chlamydia spp .; not active against Pseudomonas aeruginosa, fungi.
Tetracycline – a broad spectrum antibiotic, inhibiting RNA synthesis at the level of bacteria protein has a bacteriostatic action. It is active against Gram-negative bacteria, Chlamydia spp., Mycoplasma spp .. Rickettsia spp., Entamoeba histolylica. Resistance of microorganisms is slow.
sodium Kolistimetat (colistin) – an antibiotic which is isolated from Bacillus polymixa, var. colistinus. Provides bactericidal activity for most gram-negative bacteria (including Pseudomonas spp., Haemophilus spp.). No cross-resistance to broad-spectrum antibiotics, which act synergistically colistin.
Pharmacokinetics:
Chloramphenicol well passes through the blood aqueous barrier when applied topically. It is well distributed in body fluids (cerebrospinal fluid, bile, breast milk), it penetrates the placental barrier. Create enough concentration in the aqueous humor, partial systemic absorption. The primary route of elimination – the kidneys.
Tetracycline can not penetrate into the tissue of the eye through an intact epithelium. If the damage is the epithelium effective concentration of tetracycline in the moisture of the anterior chamber is reached after 30 minutes after application. Reaches the systemic circulation. Route of elimination – the kidneys, gastrointestinal tract.
Kolistimetat has low ability to penetrate through the mucous membrane of the eye. Absorption it increases during inflammation.
Conditions of supply of pharmacies
On prescription.
side effects
Transient blurred vision, local irritation (transient conjunctival hyperemia).
Cases of occurrence of hypersensitivity symptoms in the form of burning, angioedema, urticaria, bullous and maculopapular dermatitis. The emergence of the above symptoms requires discontinuation of the drug and the appointment of therapy.
special instructions
Since rare cases have been reported bone marrow hypoplasia due to prolonged topical use of chloramphenicol, a drug recommended to prescribe a short period of time and under the control of peripheral blood picture.
Prolonged use of agent evolving resistance.
During treatment it is necessary to control intraocular pressure.
After the drug may be a temporary reduction in clarity of vision and prior to its recovery is not recommended to drive and engage in activities that require attention and reaction.
In the period of the drug is not suitable for wearing contact lenses.
In the case of eye ointment kolbiotsin with other ophthalmic agents interval between the application of drugs should be 5-10 minutes.
Storage conditions
At a temperature of not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
A strip of ointment the length of 1-1.5 cm for a lower eyelid of the affected eye 3-4 times a day. If the application of eye ointment combined with kolbiotsin in the form of eye drops, it is sufficient application of ointment 1 time a day at night. For administration ointment should gently pull the lower eyelid down and gently pressing down on the tube, introduced into the conjunctival sac strip ointment. Then slowly lower eyelid and squeeze it with a cotton swab or cotton swab for 1-2 minutes. Thereafter, should close their eyes for 1-2 minutes.
The duration of treatment is 7-8 days. In severe cases of conjunctivitis, blepharoconjunctivitis, keratitis, dacryocystitis, as well as corneal ulcer purulent duration of treatment may be up to 14 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist