Folacin Valium 5mg 30 pc

Description

Composition
Active substance:
1 tablet contains: Folic acid – 5 mg ;.
Excipients:
Lactose monohydrate, povidone, crospovidone, microcrystalline cellulose, magnesium stearate.
Description:
Round, Valium tablets yellow color with little marbling, tolerance of inclusions orange, and Valium chamfered on one side, and odorless.
Product form:
10 tablets in PVC / Al blister. One, two or three blisters are placed together with instructions for use in a cardboard box.
Contraindications
Hypersensitivity to the drug, pernicious anemia, cancer, deficiency of cobalamin.
Dosage
5 mg
Indications
Treatment and prevention of folate deficiency on the background of an unbalanced or malnutrition;
Treatment and prevention of anemias, against folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemias associated with intestinal diseases, sprue and malabsorption .
Treatment and prevention of anemia during pregnancy and breastfeeding;
During pregnancy for the prevention of neural tube defects in the fetus;
Prolonged treatment with folic acid antagonists (methotrexate combination sulfametaksazol – trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).
Interaction with other drugs
While the use of chloramphenicol, neomycin, polymyxin, tetracyclines folate absorption decreases. With simultaneous use of folic acid reduces contraceptive effects for ingestion, ethanol, sulfasalazine, and cycloserine glutetimid, methotrexate, phenytoin, primidina, chloramphenicol. The use of folic acid can reduce the plasma levels of phenobarbital, phenytoin or primidone and cause seizure. Cases reduction or change of absorption may occur while the use of cholestyramine and folic acid, however, folic acid should be taken 1 hour before, or 4-6 hours after cholestyramine.
With the simultaneous application of the drug Folacin chloramphenicol, neomycin, polymyxin, tetracyclines Folacin absorption of the drug decreases. With simultaneous application Folacin drug reduces contraceptive effects for ingestion, ethanol, sulfasalazine, and cycloserine glutetimid, methotrexate, phenytoin, primidina, chloramphenicol. Application Folacin drug may reduce the plasma levels of phenobarbital, phenytoin or primidone and cause seizure. Cases reduction or change of absorption may occur while the application of the preparation of cholestyramine and Folacin, however, the drug should be taken Folacin for 1 hour before or 4-6 hours after cholestyramine.
Overdose
Overdose cases are not marked.
pharmachologic effect
Pharmacological group:
Vitamin; hematopoietic stimulant.
Pharmacological properties:
Vitamin group B. When folate deficiency developed megaloblastic type hematopoiesis. Stimulates erythropoiesis, is involved in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purine, pyrimidine, in the exchange of choline, histidine. During pregnancy has a protective function in relation to the action of teratogenic and damaging the fruit of factors. It contributes to the normal maturation and function of the placenta.
Pharmacokinetics:
After oral folic acid in the stomach connecting with intrinsic factor (specific glycoprotein) is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins. Deposited and metabolized in the liver to form tetrahydrofolic acid (in the presence of ascorbic acid by the enzyme dihydrofolate reductase). It penetrates the blood-brain barrier, the placenta and breast milk. Cmax is reached after 30-60 minutes in the blood. Excreted by the kidneys in unchanged form (if the received dose considerably higher than the daily requirement) as well as metabolites. Displayed by hemodialysis. 5 mg of an oral folic acid excreted over 5 hours.
Conditions of supply of pharmacies
Without recipe.
side effects
Perhaps the manifestation of allergic reactions (skin rash, pruritus, erythema, bronchospasm); Gastrointestinal: anorexia, nausea, abdominal distension, bitter taste in the mouth.
special instructions
Patients on dialysis in need of increased amounts of folic acid. Prolonged use of folic acid, especially in high doses, may decrease the blood concentration of vitamin B12. Long term use of the drug is recommended to be combined with intake of vitamin B12 (cyanocobalamin).
Ability to influence the reaction rate when driving or operating other mechanisms: No data.
Storage conditions
Store at a temperature not higher than 25 ° C, the reach of children.
Dosing and Administration
It is used inside.
For the treatment of megaloblastic anemia due to deficiency of folic acid: 5 mg per day for 4 months, for the prophylaxis – 2.5 mg per day;
For the prevention and treatment of macrocytic anemia in sprue, inflammatory bowel disease and malnutrition unbalanced or – 15 mg per day to patients with the disease sprue – 5-15 mg per day;
For the prevention of fetal neural tube defects – 2.5 mg per day for 4 weeks prior to pregnancy and continue reception for I trimester.
Higher maintenance doses can be administered to patients suffering from alcoholism, as well as patients with chronic infections and receiving anticonvulsants.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist