Fluimucil granules for solution inside 200mg 1g pack. 20 items with orange

Description

Composition
Active substance:
acetylcysteine ​​- 200 mg;
Excipients:
25 mg aspartame, betakaroten 12.3 mg Orange flavoring 100 mg sorbitol 662.7 mg.
Description:
Granules white-yellow with orange inclusions with a distinctive orange, slightly sulphurous odor.
Product form:
Granules for oral solution 200 mg.
1.0 g of granules in contour bezgyachakova package (package) of the laminate [paper / aluminum / polyethylene].
20 packets (200 mg pellet) with instructions for use placed in a cardboard box
Contraindications
Hypersensitivity to acetylcysteine, gastric ulcer and duodenal ulcer in the acute stage, phenylketonuria, fructose intolerance, children under 2 years of age, the period of lactation.
Be wary – Peptic ulcer and 12 duodenal ulcer, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, asthma, diseases of the adrenal glands, liver and / or kidney failure, hypertension.
Dosage
200 mg
Indications
Acute and chronic respiratory disease associated with the formation of a viscous trudnootdelyaemogo bronchial secretions: bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, emphysema, laryngotracheitis, interstitial lung disease, pulmonary atelectasis (due to mucus plug plugging of the bronchi).
Catarrh and purulent otitis media, sinusitis, sinusitis (promoting the removal of secretions).
Removal of viscous secretions from the airways in post-traumatic and postoperative states.
Interaction with other drugs
Combined use with acetylcysteine ​​antitussives can enhance stagnation sputum because of suppression of the cough reflex.
While the use of such antibiotics as tetracyclines (doxycycline excluding), ampicillin, amphotericin B, possibly their interaction with a thiol group acetylcysteine, which leads to reduced activity of both drugs. Therefore, the interval between doses of these drugs should be at least 2 hours.
Simultaneous treatment with acetylcysteine ​​and nitroglycerin can cause a marked decrease in blood pressure and headache.
The simultaneous use of acetylcysteine ​​and carbamazepine can be expressed at subtherapeutic levels of carbamazepine.
Activated carbon is able to reduce the effect of acetylcysteine.
Acetylcysteine ​​eliminates the toxic effects of paracetamol.
Acetylcysteine ​​may affect the results of the colorimetric determination of salicylates.
Acetylcysteine ​​may affect the analysis of ketones in the urine.
Overdose
Acetylcysteine ​​when receiving a dose of 500 mg / kg / day does not cause signs and symptoms of an overdose.
symptoms
The following symptoms may occur: nausea, vomiting and diarrhea.
Treatment: no specific antidote, treatment is symptomatic.
pharmachologic effect
Pharmacological group:
Mucolytic agent.
Pharmacodynamics:
Mucolytic agent, liquefies phlegm and increases its volume, facilitates the separation of sputum. The action associated with the ability of free sulfhydryl groups acetylcysteine ​​break intra- and intermolecular disulfide bonds, acid mucopolysaccharides mucus, resulting in depolymerization and reduction of viscosity mukoproteinov mokroty.Krome that reduces induced hyperplasia mucoid cells increases the production of surface active compounds by stimulation of type II pneumocytes, stimulates mucociliary activity that leads to improvement of mucociliary clearance.
Retains activity when purulent sputum, mucopurulent mucosa and sputum.
Increases secretion less viscous sialomutsinov goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucosal cells of the bronchi, the secret of which lyses fibrin. A similar effect on the secretion produced in inflammatory diseases of upper respiratory tract. It has an antioxidant effect due to the presence of SH-groups that can neutralize electrophilic toxins oxidation. Acetylcysteine ​​easily penetrates into cells, deacetylated to L-cysteine, which is synthesized from the intracellular glutathione. Glutathione – highly reactive tripeptide powerful antioxidant cytoprotector, trapping endogenous and exogenous toxins and free radicals. Acetylcysteine ​​prevents depletion and contributes to intracellular synthesis of glutathione involved in redox processes of cells, thereby contributing to detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for poisoning by paracetamol.
Paracetamol exerts its cytotoxic effect through a progressive depletion of glutathione. Acetylcysteine ​​primary role is to maintain an adequate level of glutathione concentration, ensuring
thus protection for the cells.
Protects alpha1-antitrypsin (elastase inhibitor) from inactivation HOCl – oxidant active myeloperoxidase produced by phagocytes. Also has anti-inflammatory action (by inhibiting the formation of free radicals and active oxygen-containing compounds,
responsible for the development of inflammation in the lung tissue).
Pharmacokinetics:
Fluimucil is well absorbed after oral administration. He immediately deacetylated to cysteine ​​in the liver. In the blood, there is dynamic equilibrium with the free and bound plasma proteins acetylcysteine ​​and its metabolites (cysteine, cystine, diatsetiltsisteina). Due to the high effect of “first pass” through the liver acetylcysteine ​​bioavailability is about 10%. Acetylcysteine ​​penetrates into the extracellular space, mainly distributed in liver, kidney, lung, bronchial secretions.
The maximum concentration reached in 1-3 hours after oral administration and is 15 mmol / l, the connection with plasma proteins in plasma – 50%.
T1 / 2 – about 1 hour, liver cirrhosis increases to 8 hours excreted by the kidneys in the form of inactive metabolites (inorganic sulfates diatsetiltsistein), a small part is released in an unmodified form through the intestine.. It crosses the placental barrier.
Pregnancy and breast-feeding
The drug is administered during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
If necessary, the appointment during lactation should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Adverse reactions listed by class and frequency sistemnoorgannomu manifestations (very often (> 1/10), often (by> 1/100 to
special instructions
Patients with bronchial asthma and obstructive bronchitis acetylcysteine ​​should be used with caution under systematic control of bronchial obstruction.
The drug contains aspartame, its use is contraindicated in patients with phenylketonuria.
The preparation comprises sorbitol, patients with rare hereditary problems with fructose intolerance the drug contraindicated.
The presence of lung sulfur odor is characteristic odor of the active substance.
When dissolving acetylcysteine ​​glassware must be used to avoid contact with metal and rubber surfaces.
Acetylcysteine ​​may marginally influence the histamine metabolism, so care must be taken when using the drug for long-term treatment of patients suffering from intolerance to histamine, the manifestation intolerance symptoms (headache, vasomotor rhinitis, pruritus).
Effects on ability to drive a vehicle, the mechanism
Special studies have been conducted on the impact of information on the ability to drive, there is no mechanism.
Storage conditions
At temperatures above 25 ° C. Keep out of the reach of children.
Dosing and Administration
Inside. The granules dissolved in 1/3 cup water.
Children from 2 to 6 years – 200 mg 2 times a day.
Children older than 6 years and adults – 200 mg 2-3 times a day.
The duration of treatment should be evaluated individually. In acute diseases duration of treatment is from 5 to 10 days; several months in the treatment of chronic diseases (on doctor’s advice).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist