Essentiale Forte N capsules. 300mg 90 pieces

Description

Composition
Active substance:
1 capsule contains: phospholipids from soybeans comprising 76% of (3-sn-phosphatidyl) – choline (synonyms: EPL, essential phospholipids) – 300 mg ;.
Excipients:
Fat is solid – 57,000 mg, soybean oil – 36,000 mg Hydrogenated castor oil – 1.600 mg, 96% ethanol – 8,100 mg, ethyl vanillin – 1,500 mg, 4-methoxyacetophenone – 0,800 mg, alpha-tocopherol – 0,750 mg.
Capsules Composition: Gelatin – 67.945 mg Purified water – 11.495 mg titanium dioxide (E 171) – 0.830 mg iron colorant oxide yellow (E 172) – 2.075 mg iron colorant oxide black (E 172) – 0.332 mg iron colorant oxide red (E 172) – 0.198 mg of sodium lauryl sulfate – 0.125 mg.
Description:
Hard gelatin capsules No 1 opaque brown pasty mass containing oily yellowish brown.
Product form:
Capsules 300 mg.
10, 12, or 15 capsules per blister made of PVC and aluminum foil, PVC / PTFHE and aluminum foil, or PVC / PE / PVDC and aluminum foil. 1) At 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 18 blister packs of 10 capsules together with instructions for use in a cardboard box 2) By 5 or 6 blisters with 10 capsules in a cardboard box. 3 cardboard packs together with instructions for use in a cardboard box. 3) At 3 blisters with 10 capsules in a cardboard box. 6 cardboard packs together with instructions for use in a cardboard box. 4) At 3, 4, 5, 6, 7, 8, 9, 10, 11 or 15 capsules blister 12 together with instructions for use in a cardboard box. 5) At 2, 3, 4, 5, 6, 7, 8, 10 or 12 capsules blister 15 together with instructions for use in a cardboard box.
Contraindications
Known hypersensitivity to phosphatidylcholine, or other auxiliary ingredients of the drug.
Children under 12 years of age (lack of sufficient evidence).
Dosage
300 mg
Indications
Chronic hepatitis, liver cirrhosis, fatty liver of different etiology, toxic liver damage, alcoholic hepatitis, liver function abnormalities when other somatic diseases.
Toxemia of pregnancy.
Prevention of recurrence of gallstone formation.
Psoriasis (as an adjunct therapy means).
The radiation syndrome.
pharmachologic effect
Pharmacological group:
Hepatoprotective agent.
Pharmacological properties:
Essential Phospholipids are the main elements of the shell structure of cells and cell organelles. In diseases of the liver there is always damage to membranes of liver cells and their organelles, which leads to impaired activity related enzymes and receptors systems, deterioration of the functional activity of the liver cells and reduce the ability to regenerate.
Phospholipids, make up the drug Essentsiale® forte H, correspond in their chemical structure endogenous phospholipids, but superior to the endogenous phospholipids by the activity due to a high content of polyunsaturated (essential) fatty acids. Embedding these high energy molecules in the damaged areas of the cell membrane restores the integrity of the hepatocytes of the liver cells, promotes their regeneration. Cis double bonds of the polyunsaturated fatty acids prevent the parallel arrangement of the hydrocarbon chains in the phospholipids of cellular membranes, phospholipid structure of cell membranes of hepatocytes “loosened”, which causes increase of their strength and elasticity, improves metabolism. The resulting functional blocks increases the activity of enzymes immobilized on membranes and promote normal, physiological way flow of essential metabolic processes.
Phospholipids, make up the drug Essentsiale® forte, regulate the metabolism of lipoproteins transferring neutral fats and cholesterol to places oxidation mainly it happens by increasing the ability to bind with high density lipoprotein cholesterol.
Thus, it appears normalizing action on the metabolism of lipids and proteins; for detoxication function of the liver; the restoration and preservation of cell structure and fosfolipidozavisimyh liver enzyme systems; which ultimately prevents the formation of connective tissue in the liver and contributes to the natural regeneration of liver cells.
When the excretion of bile phospholipids in a reduction in the lithogenic index of bile and stabilization.
Pharmacokinetics:
Over 90% of ingested phospholipids absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which is immediately subjected to inverse acetylation in polyunsaturated phosphatidylcholine, still during the suction process in the intestinal mucosa. This polyunsaturated phosphatidylcholine with shock lymph enters the bloodstream and from there, mainly associated with high density lipoproteins to the liver form.
Pharmacokinetics studies in humans were conducted using dilinoleil radiolabeled phosphatidylcholine (3H and 14C). Choline part was labeled with 3H, linoleic acid and the residue was 14C as a tag.
3H maximum concentration achieved within 6-24 hours after administration and is 19.9% ​​of the prescribed dose. The half-life choline component is 66 hours.
14C maximum concentration is achieved after 4-12 hours after administration and up to 27.9% of the prescribed dose. The half-life of this component is 32 hours. The feces detected 2% of the dose administered 3H and 4.5% of the administered dose of 14C, in the urine – 6% of the 3H and only a minimal amount of 14C.
Both isotopes of more than 90% absorbed in the intestine.
Conditions of supply of pharmacies
Without recipe.
side effects
H Essentsiale® forte generally well tolerated.
In order to assess the incidence of side effects following definitions are used: very often (> 1/10), often (> 1/100 – 1/1000 – 1/10000 –
On the part of the gastrointestinal tract
In some cases, the reception Essentsiale® forte N can cause gastric discomfort, soft stools or diarrhea.
allergic reactions
In very rare cases, possible allergic skin reactions (rash, rash, urticaria, itching).
Storage conditions
Store at a temperature not higher than 21 C.
Keep out of the reach of children.
Dosing and Administration
Inside. Capsules should be swallowed whole, squeezed with sufficient water (about 1 cup).
For teenagers over 12 years weighing more than 43 kg, as well as for adults Essentsiale® forte N is recommended to take 2 capsules – 3 times a day during meal time.
Typically, the duration of administration is not limited.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist