Ekzifin cream 1% 10g tube

Description

Composition
Active substance:
1 g of cream contains: terbinafine hydrochloride 10 mg ;.
Excipients:
Cetyl alcohol 40 mg, 40 mg stearyl alcohol, 20 mg cetyl palmitate, benzyl alcohol 10 mg, 19 mg sorbitan stearate, isopropyl myristate, 80 mg Sodium hydroxide 2 mg Polysorbate 60 61 mg Purified water 718 mg.
Description:
Uniform cream white or nearly white.
Product form:
Cream for external application of 1%.
10 g in a tube lacquered aluminum.
Each tube with instructions for use placed into cardboard pack.
Contraindications
Increased sensitivity to terbinafine or drug components.
Carefully
Kidney and / or liver failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic disease, limb occlusive vascular disease; pregnancy, lactation, infancy to 12 years (no sufficient clinical experience application).
Indications
Prevention and treatment of fungal skin diseases (trichophytosis, microsporia rubrofitii) caused by susceptible pathogens, including fungal infections stop – “fungus stops” and jock itch; yeast infections (candidiasis skin), multi-colored lichen.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Antifungal agent for topical application, with a broad spectrum of antifungal activity. At low concentrations of terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), certain molds and dimorphic fungi (Pityrosporumorbiculare). Activity against yeasts is fungicidal or fungistatic in nature, depending on the type of mushroom.
Terbinafine inhibiting squalene epoxidase in the cell membrane of the fungus, specifically suppresses the early stage of the synthesis of sterols in fungal cell, resulting in ergosterol deficiency, intracellular accumulation of squalene and destruction of the fungus cells. Squalene epoxidase is not associated with the cytochrome P450 system, so terbinafine does not affect the metabolism of hormones and drugs, which are associated with metabolism by cytochrome P450 system.
Pharmacokinetics:
Pharmacokinetics: absorption when applied topically – less than 5% has little systemic effect.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching and burning of the skin, redness at the site of application.
Overdose
For external use – is unlikely.
Symptoms in case of accidental ingestion: headache, nausea, gastralgia, dizziness, frequent urination, rash.
Treatment: activated charcoal, if necessary – symptomatic supportive therapy.
Interaction with other drugs
Any drug interactions for drug Ekzifin® cream is unknown.
special instructions
Reducing the severity of the clinical manifestations usually noted in the first days of treatment. Irregular use or premature termination of treatment increases the risk of relapse.
If after 2 weeks. treatment is not marked improvement, it is necessary to re-determine the causative agent and its sensitivity to the drug.
The treatment must comply with the general rules of hygiene for the prevention of re-infection (through clothes, shoes).
Avoid lotions and eye mucosa of the nasal cavity, mouth.
The drug has negligible systemic exposure, so it is unlikely the effect on driving vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
At a temperature not exceeding 25 C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
Outwardly.
Cream should be clean and dry the affected area before applying the medication Ekzifin®. The cream is applied thinly to the affected skin and surrounding areas and gently rub. For infections involving intertrigo (under the breasts, interdigital spaces, between the buttocks, groin), lotions application site can cover the gauze, especially at night.
The average duration and frequency of use.
Ringworm of the body, legs – 1 week 1 time per day.
Jock itch – 1 week 1-2 times a week.
Tinea pedis ( “foot fungus”) – 1 week 1 time per day.
skin candidiasis – 1-2 weeks 1 or 2 times a day.
Pityriasis versicolor – 2 weeks 1 or 2 times a day.
The duration of treatment depends on the indication and the severity of the disease.
Reducing the severity of clinical manifestations observed in the first days of treatment.
To prevent a recurrence of foot mycoses – 2-3 courses for 2 weeks with a break of 7 days.
Dosing regimens of drug Ekzifin® cream in the elderly is not different from the above.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist