Clotrimazole 1% 20g ointment tube

Description

Composition
Active substance:
100 g of ointment contain: clotrimazole 1.0 g
Product form:
Ointment for external application of 1%.
Contraindications
Hypersensitivity to clotrimazole or adjuvants, I trimester of pregnancy.
Be wary – lactation.
Indications
Fungal diseases of the skin, folds of skin mycoses, stop; pityriasis versicolor, erythrasma, superficial candidiasis, caused by dermatophytes, yeast (including Candida genus), molds and other fungi and pathogens sensitive to clotrimazole; mycoses complicated by secondary pyoderma.
Interaction with other drugs
Amphotericin B, nystatin, natamycin reduce efficiency while applying clotrimazole.
When applying the ointment negative interactions with other drugs are unknown and are not to be expected, that is. A. Resorption ability of clotrimazole very low.
Overdose
Application of ointments in high doses does not cause any reactions and conditions, life-threatening.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacological properties:
Clotrimazole is an antifungal broad-spectrum topical. Antimycotic effect of the active current ve exists clotrimazole (an imidazole derivative) is connected with the violation synthesis ergo-sterol, a component of fungal cell membranes, which changes the bridge permeable membrane and cause subsequent lysis of the cells. In low concentrations fungistatic effect, and large – fungicide, not only on the prolyl-feriruyuschie cells. The fungicidal concentrations is reacted with the mitochondria-ble and peroxidase enzymes, resulting in, An increase of the concentration of hydrogen peroxide up to a toxic level that also exists sposobst-destruction of fungal cells.
It is effective against dermatophytes, yeast and molds, as well as the causative agent of multi-colored lichen Pityriasis versicolor (Malazessia furfur) and the pathogen erythrasma. It has antimicrobial activity against grampolozhi-ing (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.
Pharmacokinetics:
Clotrimazole poorly absorbed through the skin and mucous membranes, and almost no systemic action. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes.
When applied topically clotrimazole concentration in the epidermis is greater than in the dermis and subcutaneous tissue.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.
Application of the drug directly onto the lactating mammary gland counter-indicated.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching, burning, tingling at the site of ointments, erythema, blistering, swelling, irritation and skin peeling. Allergic reactions (pruritus, urticaria).
special instructions
Not recommended to apply the drug to the skin in the eye area.
In the treatment of onychomycosis is necessary to ensure that the treated nail plate was cut short, or have a rough top-ness for better penetration of the active substance. In these cases-of’s preferences should be given to the solution because of better penetrating properties.
Patients with hepatic insufficiency should periodically monitor liver function.
When signs of hypersensitivity or irritation of the treatment was stopped.
If no effect within 4 weeks should confirm the diagnosis.
Storage conditions
In a dry place, protected from light and the reach of children at a temperature not higher than 20 ° C.
Dosing and Administration
Outwardly. Ointment applied thinly 2-3 times a day on precleaned (with soap at a neutral pH) and dry skin lesions and gently rubbed.
The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy.
tinea treatment is carried out at least 4 weeks tinea versicolor – 1-3 weeks.
Fungal diseases of the skin of the feet is recommended to continue treatment for an additional at least 2 weeks after the elimination of symptoms.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist