Candide gel vaginas. 2% 30g tuba

Description

Composition
Active substance:
1 g of gel contains: 20 mg of clotrimazole.
Excipients:
Cetyl alcohol, propylene glycol, glycerol (glycerine), benzyl alcohol, tsetomakrogolny emulsifying wax, Carbopol 940 (Carbomer 940), sodium hydroxide, hlorokrezol, purified water.
Description:
Homogeneous white gel.
Product form:
Vaginal Gel 2% of the aluminum tubes 30 g. cartridge into the applicator kit instructions for use and placed in a pile of cardboard.
Contraindications
Hypersensitivity to clotrimazole or excipients, the menstrual period, I trimester of pregnancy.
Be wary – lactation.
Dosage
2%
Indications
– genital infections caused by yeast fungi of the genus Candida and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
– genital superinfection caused by microorganisms sensitive to clotrimazole.
Interaction with other drugs
Vaginal administration of clotrimazole reduces Amphotericin B activity and other polyene antibiotics. While the use of natamycin and nystatin may decrease the activity of clotrimazole.
Overdose
Use of the drug in high doses does not cause any reactions and conditions, life-threatening.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Candide is an antifungal broad-spectrum topical. Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. In low concentrations fungistatic effect, and large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells.
It is effective against dermatophytes, yeast and molds, as well as the causative agent of multi-colored lichen (Pityriasis versicolor) and the pathogen erythrasma. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.
Pharmacokinetics:
When the absorption of clotrimazole intravaginal application is 3-10% of the administered dose. High concentrations in the vaginal secretions, and low concentrations in the blood are retained within 48-72 hours. The liver is rapidly metabolized to inactive metabolites.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching, burning, redness and swelling of the mucous membrane of the vagina; vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis to sexual partners, pain in the vagina during sexual intercourse.
special instructions
necessary simultaneous treatment of sexual partners for preventing urogenital reinfection. If trichomoniasis to more successful treatment together with Candide be applied other drugs having systemic effect (e.g., metronidazole orally). During pregnancy, treatment of vaginal gel should be carried out without an applicator.
Patients with hepatic insufficiency should periodically monitor liver function.
When signs of hypersensitivity or irritation of the treatment was stopped. Avoid contact with the drug on the mucous membrane of eyes.
Do not use the drug during menstruation.
If no effect within 4 weeks should confirm the diagnosis.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Do not freeze.
In the reach of children.
Dosing and Administration
Locally. Only for intravaginal use.
Overall the applicator with the gel (about 5 g drug) is administered in the evening in the vagina in the supine position under slightly bent legs daily for 6 days. Repeated treatment is possible after consulting a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist