Antareyt tab Gesves. 800mg + 40mg 24 pc

Description

Composition
Active substance:
1 tablet contains:
400.00 mg magaldrate, simethicone (based on the dimethylpolysiloxane) – 30.77 (20.00) mg or 800.00 mg magaldrate, simethicone (based on the dimethylpolysiloxane) – 61.54 (40.00) mg.
Excipients:
Ethyl cellulose, Macrogol-4000, sorbitol, sucralose, aspartame, caramel flavor, colloidal silicon dioxide, glyceryl dibehenate.
Description:
Biconvex tablets White or almost white, octagonal shape, with beveled edges, with an engraving in the form of apple and the letter “r” on one side. Presence of dark inclusions.
Product form:
Chewable tablets 400/20 mg and 800/40 mg. 6 tablets from a blister GSHH / A1 foil. 2 or 4 blister together with instructions for use in a cardboard box.
Contraindications
Increased sensitivity to the drug; severe renal impairment; hypophosphatemia; fructose intolerance (due to the presence in the formulation of sorbitol); Children up to age 12 years.
Carefully ; in renal failure (chronic administration may increase the content in the blood plasma of magnesium and aluminum); Alzheimer’s disease; at low levels of phosphate in the diet (the risk of failure phosphate).
Dosage
800 mg + 40 mg
Indications
Symptoms associated with acidity of gastric juice and of reflux esophagitis: heartburn, belching “sour taste” in the stomach area pain (there are irregular), a feeling of fullness or heaviness in the epigastric region, flatulence, dyspepsia (including those caused by an error in the diet , taking medications, alcohol abuse, coffee, nicotine).
Interaction with other drugs
Antareyt reduces and slows down the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H1-histamine blockers, beta-blockers, diflunisal, isoniazid, tetracycline antibiotics, quinolones (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, grepofloksatsina et al.), Azithromycin, cefpodoxime , pivampitsillina, rifampicin, anticoagulants, barbiturates, fexofenadine, dipyridamole, zalcitabine, bile acids – chenodeoxycholic and ursodeoxycholic, penicillamine, lithium and iron preparations , Quinidine, lansoprazole, mexiletine, ketoconazole.
M-holinoblokatory, slowing gastric emptying, enhance and prolong the action of the drug.
Overdose
Symptoms: if prolonged high doses are possible formation of kidney stones, constipation, drowsiness, gipermagniemiya. There may also be signs of metabolic alkalosis: mood lability, numbness or pain in the muscles, nervousness and fatigue, unpleasant taste. Treatment: it is necessary to take measures for the rapid removal of preparation: Rinse the stomach, induce vomiting, take charcoal.
pharmachologic effect
Pharmacological group:
Antacid + carminative.
Pharmacodynamics:
Combination drug action is due to the properties of its constituent components. It has antacid adsorbing, enveloping, carminative effect.
magaldrate
Magaldrate (aluminum magnesium hydroxide sulfate) neutralize free hydrochloric acid in the stomach without causing secondary hypersecretion of gastric juice. In connection with an increase in pH when it is receiving reduced peptic activity of gastric juice. It has an absorbent and enveloping effect, due to which decreases the impact of damaging factors on the mucosa of the stomach, binds bile acids.
simethicone
Simethicone alters the surface tension of gas bubbles formed in the contents of the stomach and intestinal mucus, causing their destruction. Released when the gases can be absorbed by the intestinal wall cells, due to peristalsis or output. Simethicone removes foam purely physical means, it does not enter into chemical reactions pharmacologically inert.
Pharmacokinetics:
magaldrate
Absorption of aluminum ions and magnesium in the blood is low. In normal kidney function in the blood concentration of aluminum and magnesium is not changed. In patients with chronic renal insufficiency in the blood content of aluminum and magnesium may rise to toxic values ​​as a result of violation of their excretion.
simethicone
Simethicone due pharmacological and chemical inertness after ingestion is not absorbed into the organs and tissues. After passage through the gastrointestinal tract (GIT) output intact intestine.
Pregnancy and breast-feeding
Controlled clinical studies with the study of the use of the drug in pregnant Antareyt not carried out, but in pre-clinical studies, teratogenic effects or actions have been identified. Due to lack of clinical experience, the use of the drug during pregnancy is possible only if the benefits of its application to the mother outweighs the potential risk to the fetus. appointment of the drug should be avoided during pregnancy in high doses and for a long time.
During treatment Antareyt cessation of breast-feeding is not required.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions, nausea, vomiting, taste disturbance, constipation, and diarrhea. Chronic administration of high doses – hypophosphataemia, hypocalcaemia, hypercalciuria, osteomalacia, osteoporosis, gipermagniemiya, giperalyuminiemiya, encephalopathy, nephrocalcinosis, renal function. In patients with concomitant renal failure – thirst, lower blood pressure, hyporeflexia.
special instructions
With simultaneous application Antareyt drug and other drugs should adhere interval of at least 1-2 hours. Chronic administration should ensure adequate intake of phosphorus with food. In mild and moderate renal impairment must regularly monitor the content of aluminum, calcium and phosphate in blood plasma. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.
Especially the influence of the drug on the ability to drive or work with potentially dangerous machinery
No negative impact on the ability to drive motor vehicles and operate machinery that require high concentration and speed of psychomotor reactions.
Storage conditions
In dry protected from light at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside. The tablets should be thoroughly chewed or keep the mouth to complete resorption.
Adults and adolescents over 12 years of age; If a doctor is not recommended otherwise, take 1 to 2 tablets shortly after a meal. the drug can be repeated through 2 hours as needed.
The maximum daily dose for tablets -16 400/20 mg tablet; Pill 800/40 mg – 8 tablets.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist