Afrin rhinitis by nasal spray, 15 ml., Bayer

Description

Composition
Active substance:
1 ml contains: oxymetazoline hydrochloride 0.5 mg.
White or nearly white gel-like suspension with a characteristic citrus odor.
Excipients:
Disodium edetate dihydrate 0.3 mg, 0.975 mg disodium hydrogen phosphate, sodium dihydrogen phosphate monohydrate 5.525 mg povidone K29-32 30 mg, of benzalkonium chloride solution 17% 1,471 mg macrogol 1450 50 mg benzyl alcohol 2.5 mg Microcrystalline cellulose and carmellose sodium (Avicel RC-591) 30 mg, 1.5 mg lemon flavor, purified water qs to 1 ml.
Description:
Afrin – a modern tool for the common cold as a spray with a patented formula by which it is fixed to the nasal mucosa, acting in the midst of congestion since 1st minuty.Afrin does not flow from the nose and does not drip in the throat, so that helps relieve congestion already from the 1st minute and easier nasal breathing.
Afrin is indicated for the symptomatic treatment of:
– rhinitis (runny nose)
;
– allergic rhinitis;
– Sinusitis;
– Evstahiita;
– hay fever.
Distinctive features Afrin preparation are:
– the active ingredient oxymetazoline;
– remains irabotaet where necessary: ​​it arises from the nose and does not flow into the throat.
Afrin effectively exerts its effect at the epicenter of the common cold:
– does not reduce the effectiveness of natural protection nose (1);
– is able to act within one minute;
– is able to maintain its effect until 12 hours.
1. Oxymetazoline in a concentration of 0.05% has no effect on the activity of ciliated epithelium. Zhang L et al. Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time. Ann Otol Rhinol Laryngol 2008 Feb; 117 (2): 12733. ”
Product form:
Nasal Spray 0.05%. 15 ml in a tightly closed plastic opaque bottle with capacity of 23 ml with a dosing device and a fine spray protection cap, shrink wrapped to control the first opening with the company logo. 1 bottle in cardboard box, together with instructions for use.
Contraindications
Hypersensitivity to sympathomimetic agents or to any component of the formulation.
Use of monoamine oxidase inhibitors within the preceding 2 weeks and during 2 weeks after their withdrawal.
Closure glaucoma.
Surgical intervention in the dura (history).
Condition after transfenoidalnoy hypophysectomy.
Atrophic (dry) rhinitis.
Acute cardiovascular disease or acute left ventricular failure.
Severe uncontrolled hypertension.
Children under 6 years
Carefully:
Coronary artery disease, arrhythmias, congestive heart failure, expressed atherosclerosis, hypertension, hyperthyroidism, diabetes mellitus, chronic renal insufficiency, prostatic hyperplasia with clinical symptoms, pregnancy, lactation, pheochromocytoma, porphyria, tricyclic antidepressant medications and other drugs increased blood pressure.
Dosage
0.5 mg / ml
Indications
Symptomatic therapy of rhinitis (common cold), allergic and / or inflammatory-infectious etiologies, sinusitis, evstahiit, hay fever.
Interaction with other drugs
The combined use with other vasoconstrictor drugs increases the risk of side effects. With simultaneous use of tricyclic antidepressants, monoamine oxidase inhibitors (including the period of 14 days after their withdrawal) – high blood pressure.
Overdose
When a large overdose or accidental ingestion possible: mydriasis, nausea, vomiting, cyanosis, fever, cramps, tachycardia, arrhythmia, hypertension, dyspnea, cardiac arrest, hallucination, psychiatric disorder, convulsions, pulmonary edema, depression of the central nervous system ( drowsiness, reduction of body temperature, bradycardia, decrease in blood pressure, respiration and coma stop).
Treatment: symptomatic; Accidental ingestion – gastric lavage, activated charcoal. Nonselective blockers can be used, e.g., phentolamine, to reduce high blood pressure. In severe cases, it may be necessary intubation and artificial respiration.
pharmachologic effect
Pharmacological group:
Decongestant agent – alpha-agonists.
Pharmacological properties:
Eliminates nasal congestion
It does not flow from the nose and does not flow into the throat
The action occurs within 1 minute
Duration of effect – up to 12 hours.
Pharmacodynamics:
Alfa adrenostimuliruyuschee agent for topical administration. It has a vasoconstrictor effect. Oxymetazoline causes vasoconstriction mucous membranes of the nose, paranasal sinuses and eustachian tube, which leads to a reduction of swelling and release of nasal breathing in allergic and / or inflammatory infectious rhinitis (common cold). Due to the presence in the medicament excipients (microcrystalline cellulose and carmellose sodium, and povidone K29-32) Afrin® nasal spray does not flow from the nose and does not flow down into the throat, since after the administration into the nasal passages spray becomes more viscous and is held in the mucous membranes of the nose is more effective than standard aqueous solution.
According to clinical studies the drug begins to act for 1 minute and the action continues until 12 hours.
Pharmacokinetics:
When used as a nasal spray oxymetazoline hardly detected in the blood plasma.
Pregnancy and breast-feeding
Safety of the drug in pregnant women and during lactation has not been established, so the drug should be administered to pregnant or breast-feeding only on doctor’s advice if the expected benefits of the drug to the mother outweighs the potential risk to the fetus or infant. Caution should be exercised in the presence of hypertension or signs of decrease placental blood flow. Repeated or prolonged use of large doses of the drug may reduce the placental blood.
Conditions of supply of pharmacies
Without recipe.
side effects
Overall, the drug was well tolerated, and possible undesirable effects usually mild and transient.
Immune System: hypersensitivity (allergic reactions).
From the nervous system: nervousness, anxiety, restlessness, dizziness, or lightheadedness, insomnia, somnolence, tremor, headache, hallucinations (especially in children).
From the senses: blurred vision.
Cardio-vascular system: tachycardia, palpitations, increased blood pressure, reactive hyperemia.
The respiratory system: burning and tingling sensation in the nose, sneezing, increased amounts of nasal discharge, nasal congestion gain, dry or atrophy of nasal mucosa, dry mouth, irritation of the nasal mucosa and throat, reactive hyperemia.
From the digestive system: nausea.
For the skin: rash.
On the part of the musculoskeletal system and connective tissue disorders: convulsions (especially in infants).
Miscellaneous: weakness, tachyphylaxis.
Benzalkonium chloride, part of the drug may cause local skin reactions.
special instructions
Prolonged use (more than one week) possible return of symptoms of nasal congestion. If necessary, continuation of treatment of more than 7 days should consult a doctor. Avoid getting product in eyes. Effect of the drug for medical use in the ability to operate vehicles, machinery formulation when used correctly and at recommended doses has no effect on motor driving and working mechanisms, however, when such side effects such as dizziness, should refrain from these activities.
Storage conditions
At temperatures above 25 ° C. Keep out of the reach of children.
Dosing and Administration
Intranasally.
Before each use, need to vigorously shake the spray bottle. Before the first use of a nasal spray is necessary to carry out its “calibrated” by pressing the sprayer head several times.
Adults and children over 10 years – 2 injections in each nostril at intervals of 12 hours.
Children from 6 to 10 years – 1 injection into each nasal passage with an interval of 12 hours.
do not exceed this dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist