Aevit caps. 20 pc

Description

Composition
Active substance:
1 capsule contains:
Alpha-tocopherol acetate (vitamin E) 100 mg
Retinol palmitate (vitamin A) * 100000 IU.
Excipients:
Soybean oil – 200 mg
Composition of the shell, based on the dry substance:
Gelatin – 52.75 mg
Glycerol – 16.80 mg
Methyl parahydroxybenzoate – 0.45 mg * Composition – 1.7 million IU / g
Vitamin A palmitate – 990 mg dl-alpha-tocopherol acetate – 10 mg.
Description:
Capsules spherical form from yellow to light-brown, oily liquid filled from light yellow to dark yellow color with no rancid smell.
Product form:
Capsules.
10 capsules in blisters of PVC films and paper coated or printed lacquered aluminum foil.
2, 3, 4 blisters together with instructions for use placed are placed in a pile of cardboard chrome-ersatz or paperboard boxed.
Contraindications
Hypersensitivity to the components of hypervitaminosis A and / or E, child (under 18 years), pregnancy, lactation.
Indications
A deficiency disease, E. In the treatment of skin lesions and diseases associated with impaired tissue trophism (psoriasis, certain forms of eczema, ichthyosis, seborrhoeic dermatitis).
Interaction with other drugs
Vitamin A increases the risk of hypercalcemia. Kolstiramin, colestipol, mineral oil, neomycin reduce the absorption of vitamin A and E (may require raising their dose). Oral contraceptives increase the concentration of vitamin A in plasma. Isotretinoin increases the risk of toxicity with vitamin A.
The simultaneous use of tetracycline and vitamin A in high doses (50 thousand. U. And higher) increases the risk of intracranial hypertension.
Vitamin E increases the effect of glucocorticosteroid drugs, nonsteroidal anti-inflammatory drugs, antioxidants, increases efficiency and reduces the toxicity of vitamins A, D, cardiac glycosides.
Vitamin E in high doses can cause a deficiency of vitamin A in the body. Vitamin E increases the effectiveness of antiepileptic drugs in epileptic patients (who have elevated blood lipid peroxidation products).
Simultaneous application of Vitamin E in a dose of 400 IU / day with anticoagulants (coumarin and indandione derivatives) increase the risk of bleeding and hypoprothrombinemia.
High doses of iron enhance oxidative processes in the body, which increases the need for vitamin E.
Overdose
Symptoms of acute overdose of vitamin A (occurring at 6 hours after administration) in adults – drowsiness, lethargy, diplopia, dizziness, severe headache, nausea and severe vomiting, diarrhea, irritability, osteoporosis, bleeding gums, dryness and ulceration of the oral mucosa mouth, lips peeling, skin (especially the palms), agitation, confusion.
Symptoms of chronic intoxication with vitamin A: anorexia, bone pain, fractures, and dryness of skin, lips, dryness of the oral mucosa, gastralgia, vomiting, pyrexia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, loss of hair, yellow -oranzhevye spots on the soles, palms, in the nasolabial triangle, hepatotoxic effects, increased intraocular pressure, oligomenorrhea, portal hypertension, haemolytic anemia, bone changes on radiographs, convulsions.
The symptoms of an overdose of vitamin E: the reception for a long period at doses of 400-800 IU / day – blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 IU / day for a long period – an increase in patients with hypovitaminosis risk of bleeding K metabolism disorders of the thyroid hormones, sexual function disorders, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, bleeding in the mesh eye skin, hemorrhagic stroke, ascites.
Treatment: removal of the drug, symptomatic therapy.
pharmachologic effect
Pharmacological group:
Multivitamin agent.
Pharmacological properties:
Combined preparation action is determined by the properties of its constituent fat-soluble vitamins A and E. Retinol (vitamin A) is required to regulate division and differentiation of epithelium (epithelial division enhances skin cell, rejuvenates cell population inhibits keratizatsii processes participate as a cofactor in various biochemical processes). Alpha-tocopherol (vitamin E) – has antioxidant properties, inhibits the development of free-radical reactions, formation of peroxides prevents damaging cellular membranes, which is essential for development of the organism, the normal functions of the nervous and muscular systems. Is a cofactor in several enzyme systems. Normalizes tissue capillary permeability and increases the resistance of tissues to hypoxia.
Pharmacokinetics:
Retinol palmitate well absorbed in the upper small intestine, penetrate into lymphatic paths and supplied to the liver. After administration the maximum concentration is reached after 4 hours a plasma. Retinol is unevenly distributed in the body. The highest amount is in the liver and retina, it is found in the kidney, adrenal gland and other endocrine glands. retinol metabolic products excreted by the kidneys. The half-life of 9.1 hours. Alpha-tocopherol acetate absorbed in the gastrointestinal tract, most flagged lymph, rapidly distributed in all tissues, is excreted in bile as metabolites in the urine.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions (including skin rash), epigastric pain, dyspeptic disorders (nausea, vomiting, diarrhea).
special instructions
To avoid development of hypervitaminosis A and E do not exceed the recommended dose.
In applying the drug should be considered a high content of vitamin A (100 thousand. ME) and that it is a treatment, not a preventive drug.
A diet with a high content of selenium and sulfur-containing amino acids reduces the need for vitamin E.
Storage conditions
In a dry place at a temperature protected from light not above 25 ° C. Keep out of reach of children.
Dosing and Administration
Used only on a doctor’s recommendation.
Inside, regardless of the meal, 1 caps / day. The course of treatment – 20-40 days with intervals of 3-6 months. Possible repeat courses on doctor’s advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist