Fungoterbin spray 30ml 1%

Description

Composition
Active substance:
1 g spray terbinafine hydrochloride – 10.0 mg ;.
Excipients:
Urea – 10.0 mg, butylhydroxytoluene – 10.0 mg, 95% ethanol – 150.0 mg, povidone low molecular weight – 10.0 mg Propylene Glycol – 1.0 g
Description:
Colorless transparent liquid.
Product form:
Spray for external application of 1%. 30 g of a polymer with a screw neck vials with a pump-spray dispenser. Each vial together with instructions for medical use of the drug is placed in a pile of cardboard.
Contraindications
Hypersensitivity to terbinafine and / or other ingredients, children up to 12 years (lack sufficient experience application).
Dosage
1 %
Indications
Fungal diseases of the skin caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum:
athlete’s foot / “foot fungus» (tinea pedis); mycosis body (tinea corporis), including mycosis fungoides skin smooth and large folds; inguinal tinea (tinea cruris).
Superficial Skin candidiasis caused by fungi of the genus Candida (e.g., Candida albicans).
Pityriasis versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare.
Interaction with other drugs
Any of the drug to drug interactions Fungoterbin® spray unknown.
Overdose
No cases of overdose have been reported. If by chance the drug is ingested, it is possible to expect development of the same side effects as an overdose of tablets containing terbinafine (headache, nausea, pain in the upper abdomen, dizziness). It should also be taken into account in the preparation of ethanol content.
Treatment: symptomatic and supportive therapy.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Antifungal agent for external use. Terbinafine – Fungoterbin® active substance preparation is allylamine and has a broad spectrum of antifungal activity. Terbinafine gives an early stage of the biosynthesis of the major component of the fungus cell membrane (ergosterol) by inhibiting the enzyme squalene epoxidase. Squalene epoxidase is not associated with the cytochrome P450 system.
Fungicidal effect is caused by the accumulation of squalene in the fungal cell, which is extracted from the lipid components of membranes. Accumulating intracellularly lipid granules, gradually increasing in volume, tear defective cytoplasmic membrane, resulting in fungal cell death.
Terbinafine in small concentrations has a fungicidal activity against dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis, Epidermophyton floccosum), yeasts (mainly Candida albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic (prevents further propagation of yeast fungi).
Urea, part of the spray, has a keratolytic (softening and causing the rejection of a fungal infection of the stratum corneum of the epidermis) and moisturizing effects, urea is able to raise dermatopenetrantnost (skin penetration) dosage forms and thus create a high concentration of terbinafine in the skin. Urea contributes to the rapid recovery of the epidermis. BHT – is an antioxidant agent, stimulates regeneration processes. When applied topically inhibits free radical reactions.
Pharmacokinetics:
When applied topically the drug is absorbed only slightly (absorption – 5%); accumulates in the skin, sebaceous glands, hair follicles, subcutaneous tissue and exert its action mostly at the site of application.
Pregnancy and breast-feeding
Application of pregnancy is possible only if the potential benefit to the mother outweighs the potential risk to the fetus. If necessary, use a spray Fungoterbin® lactation should avoid contact with the baby treated Fungoterbinom® area. Not recommended for use on large surfaces.
Conditions of supply of pharmacies
Without recipe.
side effects
In rare cases, in areas spray application is possible redness, itching or a burning sensation, but discontinuation of therapy because of these phenomena is rarely required. These above-mentioned symptoms should be distinguished from allergic reactions, which occur rarely, but when they occur it is necessary to stop treatment and seek medical advice – generalized rash, urticaria, angioedema.
special instructions
The treatment must comply with the general rules of hygiene for the prevention of re-infection (through clothes, shoes).
Reducing the severity of the clinical manifestations usually noted in the first days of treatment. In the case of irregular or premature treatment termination there is a risk of renewed infection. If after two weeks of treatment shows no sign of improving, there should be verification of the diagnosis.
1 vial is designed for a full course of treatment.
Spray is only intended for outdoor use. Avoid exposure of drug in the eyes and mucous membranes. In case of accidental spraying into the eyes, they should immediately wash with running water, and in the case of persistent phenomena of irritation consult a doctor.
Storage conditions
At a temperature of not higher than 20 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. The drug is applied to the skin once or twice a day. Before applying spray should be clean and dry the affected area. The preparation is sprayed onto the affected area in an amount sufficient for a thorough moistening, and furthermore, is applied to the surrounding diseased sites as well as intact skin.
The average duration of treatment:
Ringworm of the body, large folds, legs, feet: 1 week 1 time per day.
Skin candidiasis: 1-2 weeks 1 or 2 times per day.
Pityriasis versicolor: 1 week 1 or 2 times per day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist