Zovirax Duo-versatile cream-naruzhn.prim I 2g tube 1 pc


Zovirax Duo-versatile cream-naruzhn.prim I 2g tube 1 pc



Active substance:
1 g of cream contains: Active ingredient: 50 mg acyclovir, 10 mg hydrocortisone
liquid paraffin – 56.5 mg, paraffin soft white – 100 mg, isopropyl – 150 mg Sodium lauryl sulfate – 8 mg, cetostearyl alcohol – 67.5 mg poloxamer 188 – 10 mg Propylene Glycol – 200 mg Citric acid monohydrate – 1.4 mg Sodium hydroxide – 0.6 mg qs until the pH, hydrochloric acid – q.s. until the pH, purified water – q.s. to 1000 mg.
Cream for external use homogeneous, white or white color with a yellowish tinge.
Product form:
2 g – aluminum tubes (1) – packs cardboard.
Increased sensitivity to acyclovir, valaciclovir, hydrocortisone and other ingredients; skin lesions caused by other viruses, fungal, bacterial skin diseases, and parasitic infections of the skin; skin tumors, rosacea, acne vulgaris, perioral dermatitis; Children up to age 12 years.
Recurrent lip skin infection caused by the herpes virus (Herpes simplex) in adults and children older than 12 years.
Interaction with other drugs
When applied topically interaction with other drugs is not revealed.
In case of accidental ingestion or single use of the entire contents of the package of any adverse effects were observed. If you suspect an overdose, seek medical help.
pharmachologic effect
Pharmacological group:
Combined preparation containing acyclovir and hydrocortisone. Acyclovir is active against Herpes simplex type 1 and 2 virus, Varicella zoster, Epstein-Barr virus and cytomegalovirus. Thymidine kinase virus-infected cells through a series of sequential reactions actively converts acyclovir to a mono-, di-, and triphosphate of acyclovir. Last interacts with the viral DNA polymerase and incorporated into DNA, which is synthesized for new viruses. Thus, a “defective” viral DNA, which leads to suppression of replication of new generations of viruses. Hydrocortisone belongs to the low activity glucocorticosteroids. For external and topical application of therapeutic activity of hydrocortisone is due to anti-inflammatory, antipruritic, anti-allergic and antiexudativ (due vasoconstrictor effect) effect. As a result of the combination of antiviral action exerted acyclovir, and an antiinflammatory action exerted hydrocortisone Zoviraks® Duo Active drug prevents the formation of elements vesicular rash in the affected areas of the skin (when applied in a prodromal period), and also reduces the healing time already formed elements rash. The mechanism of action caused by blocking viral replication and inhibition of the inflammatory response in the affected area of ​​the skin, which reduces the severity of symptoms of the infection.
Absorption and distribution The local application of the drug acyclovir minimal systemic absorption; Hydrocortisone may penetrate the horny layer of the epidermis, reaching its lower layers, it is absorbed in a slight quantity. When used in the recommended dosage does not cause suppression of the hypothalamic-pituitary-adrenal system.
Pregnancy and breast-feeding
Application Zoviraks® Duo-Aktiv during pregnancy and lactation is not recommended, except in cases where it is prescribed by a doctor (if the expected benefit to the mother outweighs the potential risk to the fetus and child).
Conditions of supply of pharmacies
Without recipe
side effects
Adverse reactions were local in nature and occurred in the areas of application of the drug. Side effects are classified according to organ system and frequency. The frequency of side effects is defined as follows: very often (> 1/10), often (> 1/100 and 1/1000 and 1/100 1/10 000 and 000 and
special instructions
In order to achieve maximum therapeutic effect and prevent the formation of vesicles (bubbles) in the skin is necessary to start use of the drug at the first signs of the disease (burning, itching, tingling, a feeling of tightness). When expressed manifestations of HSV infections of the skin of the lips should consult a doctor. The cream can be applied only in case of skin herpes lips. It is not recommended to apply the preparation to the mucous membranes of the mouth and eyes, and also to apply a cream for the treatment of genital herpes. Avoid getting the cream in the face. Do not apply occlusive dressings and patches or special antiherpetic masking patches in place applying the cream. Patients with compromised immune systems in the treatment of any infectious disease should follow the doctor’s recommendations. Since these patients the risk of developing resistance to acyclovir is high, they should not use this drug. The preparation comprises cetyl alcohol which may cause local skin reactions such as contact dermatitis, and propylene glycol, which can cause skin irritation. Effects on ability to drive vehicles, mechanisms of drug Zoviraks® Duo-Aktiv does not affect the performance of potentially hazardous activities that require attention and fast reactions (driving and other vehicles, work with moving machinery, manager and operator of the work, etc. )..
Storage conditions
Store at a temperature not higher than 25 ° C. Do not store in the refrigerator. Do not freeze. Keep out of the reach of children.
Dosing and Administration
For external use only. Adults and children over 12 years of product should be applied 5 times a day (approximately every 4 hours), except at night. The drug is applied in a thin layer to the affected and bordering them skin. It is important as the treatment can be used to start the recurrent infection, preferably in the prodromal period, that is, at the first appearance of non-specific signs of infection (burning, tingling, feeling of tightness of the skin). The duration of treatment not less than 5 days. Do not use the drug for more than 5 days. While maintaining the symptoms of the disease after 5 days of the drug should consult a doctor. In order to prevent deterioration and to prevent the transmission of infection, wash hands before and after applying the product, do not rub or touch the affected areas of the skin with a towel.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

GlaxoSmithKline Helsker

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