Zodak tab p / 10 mg of the film 30 pc

$5.95

Zodak tab p / 10 mg of the film 30 pc

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Description

Composition
Active substance:
1 tablet contains: 10.00 mg of cetirizine dihydrochloride ;.
Excipients:
Lactose monohydrate – 73.40 mg maize starch – 33.00 mg Povidone 30 – 2.40 mg magnesium stearate – 1.20 mg; sheath: Hypromellose 2910/5 – 3.45 mg macrogol 6000 – 0.35 mg, 0.35 mg talk-, titanium dioxide – 0.80 mg Simethicone emulsion SE 4 – 0.05 mg.
Description:
Oblong tablets, film-coated, white, or almost white, with the mark for dividing the one side.
Product form:
Tablets, film-coated, 10 mg. At 7 or 10 tablets in PVC / PVDC / Al blister. Each blister of 7 tablets; 1, 3, 6, 9 or 10 blisters 10 tablets together with instructions for use in a cardboard box.
Contraindications
Increased sensitivity to the drug. End-stage renal failure (creatinine clearance
Carefully
Chronic renal failure secondary to severe (requires correction mode). Increasing age (perhaps decreased glomerular filtration). Chronic diseases of the liver (hepatocellular, cholestatic or biliary cirrhosis) (dose adjustment is only required with concomitant reduction in glomerular filtration rate).
Dosage
10 mg
Indications
Seasonal and perennial allergic rhinitis and conjunctivitis. Itchy allergic dermatitis. Pollinosis (hay fever). Urticaria (including chronic idiopathic). Angioedema.
Interaction with other drugs
Not identified clinically significant interactions of cetirizine with other drugs. Co-administration with theophylline (400 mg / day) results in a decrease in the overall clearance of cetirizine (kinetics of theophylline is not changed). The recommended dosage does not enhance the effects of ethanol (at its concentration in the blood of no more than 0.8 g / l), however, it is recommended to refrain from receiving ethanol during drug treatment.
Overdose
Symptoms: confusion, dizziness, drowsiness, confusion, stupor, weakness, anxiety, irritability, sedation, fatigue, headache, mydriasis, pruritus, tachycardia, tremor, urinary retention, dry mouth, diarrhea, constipation (often upon receipt of a day 50 mg of cetirizine), malaise.
Treatment: symptomatic therapy. A specific antidote is not revealed. Hemodialysis is ineffective. Carry out gastric lavage, activated charcoal.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H1-histamine receptor blocker.
Pharmacodynamics:
Cetirizine belongs to the group of histamine competitive antagonists N1- blocking histamine receptors, almost no anticholinergic and antiserotonin activities. Has a pronounced antiallergic effect, prevents the development and facilitates the allergic reactions. It has antipruritic and protivoekssudativnoe effect. It affects early stage of allergic reactions and also reduces the migration of inflammatory cells; inhibits selection of mediators involved in the late allergic reaction. It reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles. Removes skin reaction to the introduction of histamine specific allergens, and cooling (when cold urticaria). At therapeutic doses substantially no sedative effect. Against the background of course taking tolerance does not develop. Effect of the drug starts after 20 minutes (50% of patients), after 1 hr (95% of patients) and maintained for 24 hours.
Pharmacokinetics:
Absorption: After oral cetirizine rapidly and well absorbed from the gastrointestinal tract. The maximum blood concentration is reached after about 30 – 60 minutes. Food intake has no significant effect on the magnitude of the absorption, but in this case the rate of absorption is reduced slightly.
Distribution: cetirizine binds to plasma proteins by approximately 93%. The size distribution volume (Vd) is low (0.5 L / kg), the drug does not penetrate inside the cell. The drug does not cross the blood-brain barrier. Passes into breast milk
Metabolism: cetirizine poorly metabolized in the liver with the formation of inactive metabolite. At 10 days of administration at a dose of 10 mg drug accumulation is not observed.
Excretion: about 70% drug mainly excreted by the kidneys in unchanged form. The magnitude of systemic clearance is about 54 ml / min. After single administration of a single dose half-life is about 10 hours. In children aged from 2 to 12 years half-life is reduced to 5 – 6 hours. hemodialysis is ineffective
Pharmacokinetics in special groups of patients.
Patients with impaired renal function: with impaired renal function (creatinine clearance of less than 11-31 ml / min) and in patients on hemodialysis (creatinine clearance less than 7 ml / min), elimination half-life value is increased by 3 times, decreased clearance by 70%
Patients with chronic liver diseases (hepatocellular, cholestatic or biliary cirrhosis) in patients with cirrhosis of the liver there is an increase in half-life by 50% and reduced total clearance of 40% (a correction mode only requires the concomitant decrease in glomerular filtration rate).
Elderly patients and patients with chronic disease: with chronic diseases and elderly patients have an increase in half-life by 50% and a decrease in clearance of 40%.
Conditions of supply of pharmacies
Without recipe.
side effects
The drug is generally well tolerated. Side effects are rare and are transient in nature.
Possible side effects are given below by body system and frequency of occurrence: very often (> 1/10), often (> 1/100
special instructions
Patients with impaired renal function, liver and elderly patients before receiving the drug must consult a physician (see. The sections “Pharmacokinetics”, “Dosage and Administration”). Not recommended simultaneous use of drugs which depress the central nervous system, alcohol
Effects on ability to drive and engage in other potentially hazardous activities.
In the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Zodak® drug used by a doctor to avoid complications. Inside, regardless of meals.
Adults and children over the age of 12 years: the drug is usually prescribed Zodak® 1 coated tablet (= 10 mg of cetirizine), once a day.
Children aged 6 to 12 years: Zodak® formulation is usually administered to 1 coated tablet (= 10 mg of cetirizine), once a day or half coated tablet (= 5 mg cetirizine) twice day, morning and evening.
Patients with impaired renal function: when administering the drug to patients with impaired kidney function in the case when the alternative treatment can not be administered, the dose should be adjusted depending on the magnitude QC because cetirizine is excreted mainly by the kidneys.
QC indicator for men can be calculated from serum creatinine concentration in the blood plasma according to the following formula:
CC (ml / min) = [(140 – age (years)) x body weight (kg)] / (72 x KKsyvorot (mg / dL))
QC for women can be calculated by multiplying the obtained value by a factor of 0.85. Adult patients with impaired renal function dosing is carried out as follows:
CC (ml / min) over 80 dose of 10 mg / day
CC (ml / min) 50-79, 10 mg / day
CC (ml / min) 30-49, 5 mg / day
CC (ml / min) than 30-dose of 5 mg every other day
CC (ml / min) than 10-medication contraindicated
Only patients with impaired function of the liver correction mode is not required
If you accidentally pass the time of reception of the drug, another dose should be taken at the earliest opportunity. In that case, if the time is approaching another taking the drug, another dose should be taken according to the schedule without increasing the total dose.
Zodak® The drug can be taken regardless of the meal. Film-coated tablets should be swallowed whole with a little water.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Zodak

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