Vitamin E capsules Layfevit. 200mg 30 pieces

Description

Composition
Active substance:
alpha-tocopherol acetate – 200,000 mg;
Excipients:
sunflower oil – 15,000 mg;
capsule shell: Gelatin – 71.824 mg, 85% glycerol – 39.934 mg methyl parahydroxybenzoate – 0.072 mg carmine dye [Ponceau 4R] (E 124) – 0.319 mg purified water – 47.851 mg.
Description:
Red oval capsules filled with transparent pale yellow oil.
Product form:
Capsules 200 mg: 30 capsules in dark glass bottles.
Each vial together with instructions for medical application is placed in a cardboard box.
Contraindications
Increased sensitivity to the drug, acute myocardial infarction, childhood.
Carefully
In patients with severe cardiosclerosis, myocardial infarction, with the increased risk of thromboembolism; gipotrombinemiya caused by deficiency of vitamin K may deteriorate when using vitamin E in a dose of 400 IU (1 IU mg = 1.21).
Dosage
200 mg
Indications
Prevention and treatment of hypovitaminosis vitamin E (including, in hypovitaminosis E, accompanied by degenerative and proliferative changes in the musculoskeletal system, in particular, muscular dystrophy, amyotrophic lateral sclerosis (composed of combination therapy), chronic hepatitis (composed of combination therapy); severe states of convalescence after illnesses, injuries, operations, heavy physical exertion, menstrual irregularities (in the complex therapy for treating hormonal disorders enstrualnogo cycle).
Interaction with other drugs
It enhances the effect of corticosteroids, nonsteroidal antiinflammatory drugs, cardiac glycosides.
Enhances effectiveness of antiepileptic drugs in epileptic patients (who have elevated blood lipid peroxidation products).
High doses of iron enhance oxidative processes in the body, which increases the need for vitamin E.
Simultaneous application of Vitamin E in a dose of 400 IU per day with anticoagulants (coumarin and indandione derivatives) increase the risk of bleeding and hypoprothrombinemia. Vitamin E increases the effects of anticoagulants, if the dose exceeds 400
IU per day. Not recommended simultaneous reception of other vitamin complexes containing vitamin E, in order to avoid overdose.
Vitamin E in high doses can cause a deficiency of vitamin A in the body.
Kolesteramin, colestipol, mineral oil reduces the absorption of vitamin E.
Overdose
Symptoms: high doses of vitamin E (400 – 800 mg per day for a long time) may cause visual disturbances, diarrhea, dizziness, headache, nausea, severe fatigue, syncope, white hair growth in areas with alopecia epidermolysis bullosa. Very high doses (greater than 800 mg for a long time) may cause bleeding in patients with deficiency of vitamin K; they may interfere with the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolic events in susceptible patients.
Treatment: symptomatic, removal of the drug, the appointment of glucocorticosteroids.
pharmachologic effect
Pharmacological group:
vitamin
Pharmacodynamics:
Biologically active tocopherols protect the intermediates of cellular respiration on the functional groups of the molecules oxidation. Active tocopherols can be oxidized in semiquinones that again restored the body to tocopherols.
If there are tocopherols in the human body in sufficient quantities, they protect unstable neurotransmitters and metabolites of cellular respiration from oxidation. The redox processes at the level of cellular metabolism in pathological conditions they play a buffer role. Vitamin E (alpha-tocopherol), the most effective of tocopherols in the human body acts as an antioxidant and cell binding agent free oxygen radicals.
Vitamin E has an antioxidant effect, is involved in the biosynthesis of heme and proteins, cell proliferation, and other vital processes of tissue metabolism, prevents hemolysis. Essential for the development and functioning of connective tissue, as well as to strengthen the walls of blood vessels. It is a natural antioxidant, inhibits lipid peroxidation by free radicals. Activates phagocytosis and is used to maintain the normal resistance of erythrocytes. In high doses, prevents platelet aggregation.
Pharmacokinetics:
Absorption of duodenum 12 (requires the presence of bile salts, fats, normal functioning pancreas) – 20-40%. By increasing the degree of absorption of the dose decreases. Time to maximum concentration -. 4 hours Deposited in all organs and tissues, particularly in adipose tissue. Cross the placenta in insufficient quantities: fetal blood penetrates 20-30% of maternal blood concentrations. It passes into breast milk. Excretion mainly through the gastrointestinal tract, the bile – more than 90%, less than 6% excreted by the kidneys in the form of glucuronides and other metabolites.
Pregnancy and breast-feeding
During pregnancy and breast-feeding taking this medication only on doctor’s advice.
Conditions of supply of pharmacies
Without recipe.
side effects
Typically, when used in the recommended doses side effects are not observed.
Violations by the immune system
Allergic reactions.
Disorders of the gastrointestinal tract
Diarrhea, nausea, gastralgia.
Violations by the metabolism and nutrition
Giperkreatininuriya, increased creatine kinase activity, increasing the concentration of cholesterol in the blood serum.
Violations by vessels
Thrombophlebitis, pulmonary embolism.
special instructions
When epidermolysis bullosa in areas affected by alopecia can begin to grow white hair.
Lack of vitamin K in the body, causing hypoprothrombinemia, can be increased with high doses of vitamin E (400 IU / day).
Vitamin E increases the effects of anticoagulants, if the dose exceeds 400 IU per day. To avoid overdose is not suitable for simultaneous reception of other vitamin complexes containing vitamin E.
Effects on ability to drive a vehicle or mechanism
LAYFEVIT taking the drug, the capsule does not affect a person’s ability to drive vehicles or machinery.
Storage conditions
Stored in original package at temperature from 15 to 25 degrees.
Keep out of the reach of children.
Dosing and Administration
The drug is intended only for receiving adult patients. Treatment hypovitaminosis vitamin E capsules 100 mg 1 time per day to eliminate the symptoms of hypovitaminosis. Hypovitaminosis E, accompanied by degenerative and proliferative changes in the musculoskeletal system, in particular, muscular dystrophy, amyotrophic lateral sclerosis (composed of combination therapy) Capsules 100 mg 1 time per day for 1-2 months. Hypovitaminosis E, accompanied by chronic hepatitis (composed of combination therapy) Capsules 100 mg 1 time per day. Hypovitaminosis E under conditions rekovalestsentsii after severe diseases, injuries, operations Capsules 100 mg 1 time per day for 1-2 weeks. Hypovitaminosis E at elevated physical activity Capsules 100 mg 1 time per day during increased physical activity.
Hypovitaminosis E, accompanied by menstrual irregularities (in the complex therapy with hormonal treatment of disorders of the menstrual cycle) 300-400 mg every other day series, starting with the 17 day cycle until the last day of the cycle (the day before the first day of menstruation).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist