Vibrocil Nazal drop. 15ml vial, cap.

Description

Composition
Active substance:
Per 1 ml: 2.5 mg phenylephrine, dimethindene maleate 0.25 mg.
Excipients:
Benzalkonium chloride 50% solution (based on benzalkonium chloride) – 0.2 mg (0.1 mg), citric acid monohydrate – 2.6 mg sodium phosphate – 4.4 mg Sorbitol – 35 mg, lavender oil – 0.2 mg, water – up to 1 ml.
Description:
Nasal drops in the form of a clear solution from colorless to weakly yellow-colored, low odor lavender.
Product form:
Nasal drops in 15 ml amber glass screw cap vial c-pipette. The vial together with instructions for use placed into cardboard pack. On the secondary packaging allowed to have tamper-evident.
Contraindications
– atrophic rhinitis (including with fetid – ozena); – simultaneous MAO inhibitors and up to 14 days after their withdrawal; – closure glaucoma; – Children up to age 1 year; – increased sensitivity to phenylephrine, dimethindene maleate or other ingredients.
Dosage
2.5 mg + 0.25 mg / ml
Indications
– acute rhinitis (including the common cold); – allergic rhinitis (including with hay fever); – vasomotor rhinitis; – chronic rhinitis; – acute and chronic sinusitis; – acute otitis media (as an adjuvant); – Preparation for surgical interventions in the area of ​​the nose and the elimination of edema of the nasal mucosa and sinuses after surgery in this area.
Interaction with other drugs
Phenylephrine (like other vasoconstrictors) is contraindicated in patients receiving MAO inhibitors in a given time or receive them during the previous 2 weeks. Should not be administered simultaneously with the preparation of tri- and tetracyclic antidepressants, beta-blockers.
Overdose
An overdose of the drug can cause Vibrotsil® sympathomimetic effects, such as increased heart rate, ventricular premature contraction of the heart, headache in the neck, tremors, fatigue, increased blood pressure, excitement, insomnia, pale skin. The drug may also cause light sedation, dizziness, stomach pain, nausea, vomiting. Treatment: the use of activated charcoal, laxatives in young children; over 6 years in adults and children – drinking large amounts of fluids. No specific antidote. Elevated blood pressure induced by phenylephrine can be eliminated by applying the alpha blockers.
pharmachologic effect
Pharmacological group:
R01AB01
Pharmacodynamics:
Vibrotsil® – combined formulation comprising phenylephrine and dimethindene. Phenylephrine – sympathomimetic, when applied topically has a moderate vasoconstrictor effect (by stimulation of 1-adrenoceptors located in the venous blood vessels of the nasal mucosa?), Eliminates the swelling of the nasal mucous membrane and paranasal sinuses. Dimethindene is antiallergic – antagonist of histamine H1-receptor antagonists; It does not reduce the activity of the ciliated epithelium of the nasal mucosa.
Pharmacokinetics:
Vibrotsil® for topical application, and its activity is not dependent on active substance concentration in the blood plasma.
Pregnancy and breast-feeding
Given the potential systemic vasoconstrictor effect, Vibrotsil® not recommended during pregnancy and lactation (breastfeeding).
Conditions of supply of pharmacies
Without recipe
side effects
Determination of the frequency of side effects (WHO): very often (> 1/10), often (by> 1/100 to
special instructions
Vibrotsil® should not be used continuously for more than 7 days without consulting a doctor. Long term or excessive use may cause tachyphylaxis effect and “bounce” associated with the re-development of nasal congestion (rhinitis medicamentosa), lead to the development of systemic vasoconstrictive action. Do not exceed the recommended dose of the drug Vibrotsil®. Otherwise, it may develop systemic manifestations of the drug, especially in children and elderly patients. In children under 6 years are used only to nose drops. Vibrotsil® no sedative action (does not affect the speed of psychomotor reactions). Effects on ability to drive vehicles and mechanisms are not affected.
Storage conditions
The drug should be kept out of reach of children at a temperature not higher than 30 ° C.
Dosing and Administration
Children under the age of 1 year: contraindicated. Children aged 1 to 6 years (under adult supervision): 1-2 drops in each nostril 3-4 times / day. Children aged 6 to 12 years (under adult supervision): 3-4 drops in each nostril 3-4 times / day. Teenagers over the age of 12 years and adults: 3-4 drops in each nostril 3-4 times / day. Before application it is recommended to thoroughly clean the nasal passages; buried in the nose, his head thrown back. This head position is maintained for a few minutes. The drug should not be used continuously for more than 7 days. If symptoms persist, consult your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist