Valium 300 Valium n / 300mg film about 30 pc

Description

Composition
Active substance:
1 ml ampoule 12 comprises: ethylenediamine salt of thioctic (alpha-lipoic acid) 0.388 g (in terms of thioctic (alpha-lipoic acid) – 0.300 g); 1 tablet contains: thioctic (alpha-lipoic acid) – 300 mg ;.
Excipients:
1 ampoule contains: propylene glycol, ethylene diamine, water for injection. 1 tablet contains: lactose monohydrate, magnesium stearate, microcrystalline cellulose, croscarmellose sodium, povidone (K value = 30), silica, colloidal anhydrous; coated – Opadry OY-S-22898 “yellow”, consisting of: hypromellose, titanium dioxide (E 171), sodium dodecyl sulfate, liquid paraffin, dye quinoline yellow (E 104) dye yellow-orange (E 110) and paraffin liquid .
Product form:
Concentrate for solution for infusion of 25 mg / ml.
12 ml of the product in vials dark glass hydrolytic type I (Eur. F.) with a white ring at the top of the ampoule.
5 ampoules per carton contour packaging (tray) with instructions for use in a cardboard package.
Tablets, coated tablets, 300 mg.
10 tablets in a blister from a film opaque PVC / PVDC / Aluminum foil.
3 blisters together with instructions for use placed in a cardboard box.
Contraindications
Increased sensitivity to the drug.
Pregnancy, breast-feeding (not enough experience with the drug).
Children’s age (efficacy and safety have not been established).
Dosage
300 mg
Indications
Diabetic and alcoholic polyneuropathy.
Interaction with other drugs
In vitro thioctic acid reacts with the metal ion complexes (e.g., cisplatin), and therefore, while the application Valium 300 may reduce the effect of cisplatin.
With simultaneous application Berlition® 300 enhances the effect of insulin and oral hypoglycemic agents. Alcohol (ethanol) reduces the therapeutic activity of thioctic acid.
Injection mold
Since sugar molecules thioctic acid forms poorly soluble complex compounds. Consequently, the infusion solution is not compatible with thioctic acid dextrose solution, Ringer’s solution, and solutions which can be reacted with compounds of the SH-groups or having disulfide links.
tablet form
After ingestion Berlitiona® 300 morning apply preparations of iron, magnesium, as well as to consume dairy products (due to the content of calcium) is recommended in the afternoon or evening.
Overdose
Symptoms: headache, nausea, vomiting.
Treatment: symptomatic. No specific antidote.
pharmachologic effect
Pharmacological group:
Metabolic means.
Pharmacodynamics:
Thioctic acid (alpha-lipoic) – endogenous antioxidant (binds free radicals) in the body formed by the oxidative decarboxylation of alpha-keto acids. As coenzyme mitochondrial multienzyme complexes involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Thereby reducing blood glucose and increased glycogen content in the liver, as well as overcome the insulin resistance. By the nature of the biochemical actions similar to B vitamins involved in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function.
It has hepatoprotective, lipid-lowering, cholesterol-lowering, hypoglycemic effect. Use of thioctic acid salt of ethylenediamine in solution for in / in (having a neutral reaction) reduces the severity of side reactions.
Pharmacokinetics:
It has the effect of “first pass” through the liver. The formation of metabolites occurs as a result of oxidation of the side chain and conjugation.
The volume of distribution – about 450 ml / kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%).
Injection mold
When administered intravenously, the time to reach maximum concentration – 10-11 min, the maximum concentration – 25-38 g / ml, area under the concentration-time – about 5 ug h / mL.
tablet form
When ingestion rapidly and completely absorbed from the gastrointestinal tract (reception with food reduces the absorption). Time to maximum concentration – 40-60 minutes. Bioavailability – 30%.
The half – 20-50 min. Total plasma clearance – 10-15 ml / min.
Conditions of supply of pharmacies
On prescription.
side effects
Mold for injection:
Usually Berlition® 300 is well tolerated. Very rarely possible convulsions; diplopia; petechial hemorrhages in the mucous membranes, the skin; thrombocytopathy; purpura (purpura); thrombophlebitis; the rapid introduction may increase intracranial pressure (occurrence of a feeling of heaviness in the head); difficulty breathing. These side effects are alone. Possible local reactions at the injection site (burning); allergies: urticaria, systemic allergic reactions (up to the development of anaphylactic shock). Perhaps the development of hypoglycemia (due to improved glucose uptake).
Tablet form:
Usually Berlition® 300 is well tolerated. Possible indigestion, including nausea, vomiting, heartburn. In some cases, may develop cutaneous allergic reactions (urticaria). Perhaps the development of hypoglycemia (due to improved glucose uptake).
special instructions
Patients taking the drug Berlition® 300, should refrain from drinking alcohol.
Diabetic patients requires constant monitoring of blood glucose concentration, especially at the initial stage of therapy. In some cases it is necessary to reduce the dose of insulin or oral hypoglycemic agents, in order to avoid hypoglycemia.
Injection mold
The solution should be protected from exposure to light, for example, by means of aluminum foil. Protected from light solution can be stored for about 6 hours.
Storage conditions
In the dark place at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Mold for injection:
The daily dose of 300-600 mg (1-2 ampoules). 1-2 ampoules preparation (12-24 ml) is diluted in 250 ml of physiological 0.9% sodium chloride solution and administered intravenously for approximately 30 minutes.
In the early course of preparation is administered intravenously over 2-4 weeks. Then one can continue receiving thioctic acid orally at a dose of 300-600 mg per day.
Tablet form:
Assign inside of 600 mg (2 tablets) 1 time per day. The tablets are fasting for approximately 30 minutes before the first meal, liquid squeezed a sufficient amount of liquid. The duration of treatment determined by the doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist