Valacyclovir tab n / 500mg film about 10 pieces of ozone


Valacyclovir tab n / 500mg film about 10 pieces of ozone



Active substance:
1 tablet contains: valaciclovir hydrochloride – 556.2 mg, based on the valaciclovir – 500.0 mg.
Product form:
Tablets, film-coated, 500 mg, 1000 mg. At 7, 10, 28, 30 tablets in blisters of PVC film and aluminum foil printed patent. At 7, 10, 20, 28, 30, 40, 42, 50, 60 or 100 tablets in banks of PET, sealed with lids screw-with the control of the first opening or the system “push-turn” of polypropylene or polyethylene, or polymer cans polypropylene for medicaments sealed with lids tensioning with the control of the first opening of polyethylene TU 9464-002-95202676-2011. One jar or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 contour of cellular packaging together with instructions for use placed in a cardboard box (pack).
• Hypersensitivity to valacyclovir, acyclovir and any auxiliary components that make up the drug. • Children under 12 years of age for the prevention of infections caused by cytomegalovirus (CMV) infection and disease following solid organ transplantation. • Children up to age 18 years for all other readings (due to insufficient data on the clinical trials for this age group). • HIV infection in CD4 + lymphocytes content of less than 100 / ml.
500 mg
Adults: • The treatment of shingles (Herpes zoster). The drug Valacyclovir helps relieve pain, reduce its duration and percentage of patients with pain caused by herpes zoster, including acute and post-herpetic neuralgia. • Treatment of infections of the skin and mucous membranes caused by HSV, including first identified and recurrent genital herpes (Herpes genitalis), as well as labial herpes (Herpes labialis). • Prevention (suppression) of recurrences of skin infections and mucous membranes caused by HSV, including genital herpes. • Prevention of transmission of genital herpes when taking a healthy partner as suppressive therapy in combination with safer sex. Adults and adolescents aged 12 years and older: • Prevention of infections caused by cytomegalovirus (CMV) infection and disease following solid organ transplantation.
pharmachologic effect
Pharmacological group:
An antiviral agent. ATC code J05AB11.
Pharmacological properties:
Valaciclovir is the antiviral agent is an L-valine ester of acyclovir. Acyclovir is a nucleoside analogue of a purine (guanine). In humans, valacyclovir is rapidly and completely converted to acyclovir and valine under the action of the enzyme valatsiklovirgidrolazy. Acyclovir has in vitro specific inhibitory activity against herpes simplex virus (HSV) 1 and type 2 virus, varicella-zoster virus (VZV – varicella-zoster virus), cytomegalovirus (CMV), Epstein-Barr virus (EBV ) and human herpes virus type 6. Acyclovir inhibits viral DNA synthesis and the phosphorylation immediately after conversion to the active form of acyclovir triphosphate. The first stage of phosphorylation takes place with the participation of virus-specific enzyme. For HSV, VZV and EBV this enzyme is the viral thymidine kinase, which is only present in virus infected cells. Partial selectivity in phosphorylation stored and cytomegalovirus mediated through product phosphotransferase gene UL97. Activation of acyclovir specific viral enzyme largely explains its selectivity. Acyclovir phosphorylation process (conversion of a mono- triphosphate) is completed by cellular kinases. Atsiklovirtrifosfat competitively inhibits viral DNA polymerase, and being a nucleoside analogue, is incorporated into the viral DNA, which leads to rupture obligate chain termination of DNA synthesis and therefore to block viral replication. In patients with immunocompetent HSV and VZV with reduced sensitivity to valacyclovir are extremely rare, but can sometimes be found in patients with severe immune disorders, eg, bone marrow transplant patients receiving chemotherapy for malignant tumors and in HIV-infected patients. Resistance to aciclovir is usually caused by a deficiency virus thymidine kinase, that leads to excessive proliferation of the virus in the host organism. Sometimes reduction of sensitivity to acyclovir due to the appearance of virus strains with impaired viral thymidine kinase or DNA polymerase structure. The virulence of the virus species resembles that of his wild strain.
Conditions of supply of pharmacies
Dosing and Administration
Inside. The drug Valacyclovir is taken regardless of the meal, the tablet should be taken with water.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

OZONE generics

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