Vagiferon suppositories vaginas. 10 pieces


Vagiferon suppositories vaginas. 10 pieces



Composition Active substance 1 suppository contains: interferon alpha-2b, recombinant human least 50,000 ME, metronidazole, 250 mg, 150 mg fluconazole. Excipients: Boric acid 400 mg Disodium edetate 2 mg to 2 g of base: Macrogol 1500 – 92% macrogol 400 – 8%. Description: Suppositories white or white with a yellowish shade, torpedo-shaped. Product: Vaginal Suppositories. 5 suppositories in blisters. One or two blisters together with instructions for medical application is placed in a cardboard box. Hypersensitivity to the drug (including nitroimidazole derivatives), pregnancy, children up to 18 years (the effectiveness and safety of the drug is not installed). Indications Bacterial vaginosis bacterial (nonspecific) vaginitis, vaginitis caused by mixed infection (Trichomonas, gardenerelly, yeast-like fungi, Herpes simplex virus types 1 and 2, Mycoplasma, Ureaplasma,) in a complex therapy. The interaction with other drugs is not recommended to combine with the non-depolarizing muscle relaxants (vecuronium bromide). Possible joint use of a macrolide antibiotic (josamycin) systemic action. Overdose Cases of overdose have been identified. When metronidazole overdose may be nausea, vomiting, abdominal pain, diarrhea, itching, “metallic” taste in the mouth, ataxia, dizziness, paraesthesia, seizures, leukopenia, dark urine staining. The drugs Group: The antimicrobial agent combined (+ antibacterial antiviral and antifungal protivoprotozoynoe +). Pharmacodynamics: Combined preparation for intravaginal use. VAGIFERON® possesses antiviral, immunomodulatory, antiinflammatory, antifungal, antiprotozoal and antimicrobial (trihomonatsidnym) effect. Interferon alpha-2b has a pronounced antiviral, immunomodulating properties. Metronidazole – antiprotozoal and antibacterial drug, 5-nitroimidazole derivative. The mechanism of action is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with DNA of microbial cells, inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against Trichomonas vaginalis, Gardnerella vaginalis, as well as Gram-negative anaerobes Bacteroides spp. (Including B. fragilis, B. distasonis, the status B., B. thetaiotaomicron, B. vulgaris), Fusobacterium spp. Gram-positive and certain anaerobes (chuvstvi¬telnye strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp., Mobiluncus spp.). Insensitive to metronidazole aerobic microorganisms and facultative anaerobes. Fluconazole has highly specific antifungal (fungicidal) effect. Active at mycosis, including caused by Candida spp. (Including generalized forms of candidiasis in the background immunosuppression), Cryptococcus neoformans and Coccidioides immitis, Microsporum spp., Blastoyces dermatitidis. When intravaginal application especially active against Candida albicans, to a lesser degree – in respect of Candida glabrata. Pharmacokinetics after administration of intravaginal metronidazole bioavailability of 20% compared with oral administration. After intravaginal subjected to systemic absorption (about 56%). It is metabolized in the liver by hydroxylation and oxidation glyukuronirovaniya. Activity of the main metabolite (2-oximetronidazole) is 30% of the activity of the parent compound. The half-life of 6-12 hours. The deduced by 40-70% (about 20% in unmodified form) through the kidneys. Pharmacokinetics of interferon and fluconazole in intravaginal application of the method has not been studied. Pregnancy and lactation The drug is not used during pregnancy. Metronidazole passes into breast milk. Breast-feeding in the period of the drug should be canceled. Resuming breast vskarmli¬vanie should be no earlier than 48 hours after drug application. Conditions of supply of pharmacies by prescription. Side effects When applied topically adverse effects are not revealed. In some cases, possible allergic reactions and local reactions. Side effects specific to metronidazole, as its systemic absorption is 56%: an allergic reaction (rare), leukopenia, ataxia, mental changes (anxiety, mood lability), convulsion, seldom diarrhea, constipation, dizziness, headache, loss of appetite, nausea , vomiting, abdominal pain and cramps, changes in taste (rare), dry mouth, “metal”, or bad taste, fatigue. Special instructions: In the period of treatment is recommended to abstain from sexual intercourse. In the case of the drug in conjunction with metronidazole for oral administration, especially when repeated course, necessary to monitor patterns of peripheral blood (risk of leukopenia). In the period of treatment is contraindicated receiving ethanol (development disulfirampodobnyh reactions: abdominal pain, spastic nature, nausea, vomiting, headache, a sudden “surge” of blood to the face). Metronidazole should not be administered to patients who have taken disulfiram within the past 2 weeks. The drug does not affect the ability to drive and engage in other potentially hazardous activities that require high concentration and psychomotor speed reactions. Storage conditions at a temperature of from 2 ° C to 8 ° C. Keep out of the reach of children. Dosing and dose Intravaginal. 1 suppository evening (before bedtime), for 10 days. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

Firn M

Release Form

rectal suppositories

Active ingredients

interferon alfa-2b + + metronidazole, fluconazole



Amount in a package

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