Tservikon-Dim suppositories vaginas. 100mg 25 pieces


Tservikon-Dim suppositories vaginas. 100mg 25 pieces


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Composition Active ingredient: 100 mg diindolylmethane; Excipients: hard fat (Witepsol H 15) (1.9795 g); crospovidone (Kollidon CL) (0,0200 g); carmine red dye, E 120 (0.0005 g). Description: Cuppozitorii from light pink to yellowish pink color, Valium forms. Product: Packaging – 25 suppositories 100 mg. Contraindications Hypersensitivity of any component of the drug. During pregnancy and breastfeeding. Children up to age 18 years. Dosage 100 mg Indications Treatment dysplasia (cervical intraepithelial neoplasia) uterine cervix (irrespective of detection results of human papillomavirus infection by PCR). Interactions with other drugs have not been studied. In the absence of systemic pharmacokinetics, It is not expected any interaction with drugs of systemic use. The drug should not be used in conjunction with topical preparations for intravaginal application relating to a group of antiseptics-oxidants (permanganate, potassium, iodine, hydrogen peroxide). Symptoms of overdose are unknown. Pharmacological action Pharmacological group: other antineoplastic drugs Pharmacodynamics: Preparation Tservikon®-DIM as active substance comprises diindolylmethane, which is a means of stimulating apoptosis infected with human papillomavirus (HPV) and transformed cells, as well as a stimulator of expression of receptors for interferon gamma. Thereby, the therapeutic effect diindolylmethane is its ability to accelerate the elimination of infection by human papilloma virus and the transformed cells and enhance non-specific immune response to infection. Furthermore, diindolylmethane normalizes metabolism of estradiol in HPV-infected cells, preventing the formation of carcinogenic metabolite of estrogen (16alfa-hydroxyestrone), which stimulates expression of HPV oncogenes. By suppressing the expression of the oncogene E7 HPV Diindolymethane blocks the hormone dependent pathological proliferation of HPV-infected cells. Diindolylmethane relates to a substantially non-toxic drugs (LD50 greater than 5 g / kg). Pharmacokinetics When intravaginal application diindolylmethane has high local bioavailability and thus practically reaches the systemic circulation. Pregnancy and breast-feeding Do not use this drug during pregnancy and lactation. Conditions of supply of pharmacies by prescription. Side effects drug is usually well tolerated by patients. In some cases, there may be listed below, usually reversible adverse events. Adverse events reported below are listed according to the anatomical and physiological classification and frequency of occurrence. The frequency of side effects is classified by WHO and has a gradation: very common (> 1/10), common (> 1/100 and Cautions In the treatment of vaginal infections drug should not be used during menstruation time, it is advisable to start treatment after menstruation During treatment is recommended. abstain from sexual intercourse. During treatment, it is recommended to use contraception. Effect on the ability to drive mechanisms and drug-DIM Tservikon® not affect the ability to drive vehicles and mechanisms. Storage conditions in the dark place at a temperature of from 2 ° C to 8 ° C. Keep out of reach of children. Dosing and dose Intravaginal 100 mg 2 times a day. Duration of treatment 3-6 months. The duration of treatment is determined by the dynamics of clinical and laboratory parameters. Recommendations for the method of administration: The drug is administered into the vagina 2 times a day (morning and evening) 1 suppository. Immediately before administration is necessary to wash your hands thoroughly. The suppository is administered deeply in the vagina in the supine position. After introduction of the use recommended by the sanitary napkin. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg




Release Form

vaginal suppositories

Active ingredients



100 mg

Amount in a package

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