Trombless plus gel appearance. 1000me / g 50g

Description

Composition
Active substance:
1 g of gel contains sodium heparin – 1,000 IU (8.33 mg activity at sodium heparin 120 IU / mg), troxerutin – 20.0 mg, dexpanthenol -100.0 mg, benzocaine – 1, 0 mg ;.
Excipients:
Ethanol – 100.0 mg methyl parahydroxybenzoate – 1.5 mg, trolamine – 7.0 mg carbomer – 10.0 mg Glycerol – 50.0 mg Water – up to 1.0 g
Description:
A transparent or translucent gel from light yellow to yellow, greenish tint is allowed. It has a weak characteristic odor.
Product form:
Gel for external application.
10, 20, 30, 40, 50 or 100 g per tube in aluminum or plastic laminate tubes. Each tube together with instructions for medical use of the formulation was put in a pile of cardboard.
Contraindications
Hypersensitivity to the drug, open infected wounds or wounds with abundant exudation in the site of the proposed application, children up to 18 years (data on the efficacy and safety of the drug is not present), pregnancy and lactation.
Carefully
Increased tendency to bleeding, thrombocytopenia.
Indications
The symptom of chronic venous insufficiency (including on the background of varicose veins of the lower limbs), migrating phlebitis, thrombophlebitis of superficial veins.
Subcutaneous hematoma, localized edema and aseptic infiltrates.
Trauma and injuries of joints, tendons, muscle tissue.
Complications arising after surgical operations on the veins.
Interaction with other drugs
The combined use of a gel with oral anticoagulants may cause elongation of prothrombin time. Non-narcotic analgesics and anticholinesterase drugs enhance the effect of the included drug benzocaine. Benzocaine reduces the antibacterial activity of sulfonamides.
Overdose
About the cases of drug overdose Trombless® Plus Gel has not been reported.
pharmachologic effect
Pharmacological group:
Anticoagulant means of direct action for local application + other drugs.
Pharmacological properties:
Combined preparation.
Sodium Heparin – direct anticoagulant, anti-inflammatory, antiproliferative, anti-inflammatory and analgesic action. Decreases platelet aggregation binds antithrombin III, preventing the passage of prothrombin to thrombin. Depresses the activity of thrombin. It reduces the activity of hyaluronidase, increases fibrinolytic properties of blood. Improves microcirculation and activates tissue metabolism, thereby accelerates the resorption of hematomas and blood clots, eventually restores patency of vein is clinically accompanied by a pronounced analgesic and anti-inflammatory action.
Dexpanthenol – provitamin B5 – the skin is transformed into pantothenic acid that is part of coenzyme A, which is involved in the acetylation processes, carbohydrate and fat metabolism; stimulates the regeneration of the skin, normalize cellular metabolism, increases the strength of collagen fibers. Provides regenerating, vitamin, metabolic and anti-inflammatory effect.
Troxerutin – flavonoids (rutin derivative), has a P-vitamin activity; It has venomotor, angio, anti-inflammatory, antioxidant and anti-inflammatory effect. Is involved in redox processes, blocks hyaluronidase, hyaluronic acid stabilizes cellular membranes and reduces the permeability and capillary fragility increases their tone. Increases the density of the vascular wall reduces exudation of the liquid part of the plasma and blood cell diapedesis. It reduces inflammation in the vascular wall, limiting the adhesion to the surface of platelets.
Benzocaine – local anesthetic for surface anesthesia. It decreases cell membrane permeability to sodium ions displace calcium ions from the receptors located on the inner surface of the membrane, blocking the conduction of nerve impulses. It prevents the emergence of pain impulses in the sensory nerve endings and the conduct of the nerve fibers. Benzocaine expands surface vessels, contributing to the absorption of heparin.
Pharmacokinetics:
Minor amounts of heparin absorbed from the skin into the systemic circulation. The maximum concentration of drug in the blood observed after 8 hours after application. Excretion of heparin occurs mainly via the kidney, half-life 12 hours.
Troxerutin well absorbed from the skin at external use.
Dexpanthenol for topical application quickly absorbed by the skin and is transformed into pantothenic acid. Its concentration in the blood – 0.5-1 mg / l in the blood serum – 100 g / l. Pantothenic acid is not subjected to metabolism in the body (except for inclusion of coenzyme A) is output unchanged.
Benzocaine percutaneous application practically not absorbed.
Pregnancy and breast-feeding
Use of the drug Trombless® Plus during pregnancy and breast-feeding is contraindicated.
Conditions of supply of pharmacies
Without recipe.
side effects
Prolonged use of the drug possible local skin reactions such as hyperemia, reducing sensitivity (application site), allergic reactions (rash, pruritus).
special instructions
Not intended for use in ophthalmology, for intravaginal administration.
Storage conditions
At temperatures above 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Topically, applied in a thin layer on the skin over the affected region and around it, evenly distributed over the surface of the skin with gentle circular movements 2-3 times per day. A course of treatment
2-3 weeks, with repetition for relapsed disease.
When trophic ulcers with slight exudation of the wound surface before applying purified by exudate and necrotic tissue, if necessary washed with a hydrogen peroxide solution 3% nitrofural 1: 5000 or chlorhexidine 0.05% and dried. The gel is applied to a thin uniform layer on the entire skin surface and impose a sterile gauze bandage. Changing bandages produce 1 time per day. In the open method of treatment preparation is applied 1-2 times per day. The duration of treatment is determined by the dynamics of epithelialization.
When subcutaneous hematomas, localized edema, aseptic infiltrates, injuries, bruises and similar conditions applied to the affected area 2-3 times a day until complete recovery of the normal state of damaged tissues.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist